Download MBBS Physiology Presentations 53 Wbcs Lecture Notes

Download MBBS (Bachelor of Medicine, Bachelor of Surgery) 1st Year, 2nd Year, 3rd Year and Final year Physiology 53 Wbcs PPT-Powerpoint Presentations and lecture notes

WBCs

Learning Objective

Eosinophil characteristics, functions and causes of variations in number

Basophil & mast cells characteristics, functions and causes of variations in

number

Monocyte-Macrophages characteristics, functions and causes of

variations in number


Eosinophils

? Size- 10-14m, Nucleus - central or eccentric- 2-3

lobed `spectacle shaped' ;

coarse granules with bright brick red color;

Granules - large; coarse;

? Differential count : 1- 4% ?Absolute count : 40 -

440/l of blood

?They are especially abundant in tissues that

come into contact with the external environment

Eosinophil-Granules

Contents in Granules


Functions of Eosinophils

? Defense against helminthic parasitic infestation (worm)

? Combat immediate hypersensitivity reactions (Allergy)

Major basic protein eosinophil cationic protein; these proteins are toxic to several parasites and to mammalian cells.

These proteins bind heparin and neutralize its anticoagulant activity as well.

Eosinophil-derived neurotoxin can severely damage myelinated neurons.


Easinophil- Causes of variation in Number

Eosinophilia :Increase in eosinophils= > 500/mm3

Causes-


Eosinopenia :Decrease in eosinophils= < 50/mm3

Causes-


Basophils & Mast Cells

Basophils

Size : 10-14m; Nucleus : central; 2-3 lobes; overlaid with very coarse purplish blue
granules
Normal values ?Differential :0-0.1? %Absolute :1 - 100/l of blood
Granules Contents :


Mast Cells

Usually present in tissues with more propensity in mucosal

and connective tissues

Round or elongated cells and nu is without segmentation

It is also formed in BM but absent in blood

Life span-few months

Quite similar to Basophil in Content and functions

Basophils & Mast Cells-Functions

Function: This cell along with mast cells have been associated with-
Hypersensitivity reaction (Acute allergy)
Systemic Hypersensitivity reaction (Anaphylaxis)
Especially in the persons having ATOPY tendency.
Basophil- Causes of variation in Number

Basophilia:

Causes-

Basopenia:

Causes-

Monocytes ? Macrophages system


Monocytes-Macrophages

Monocytes )4%?8(%, 12?18 ,

Nucleus-? violet ?large single ?may be indented /horse

-shoe/kidney/oval shaped

Cytoplasm- ?Abundant ?blue ?amount is usually more

than that of nucleus. ?no visible granules.

Monocytes enter the blood from the bone marrow and

circulate

for about 72 h. They then enter the tissues and become

`Tissue Macrophages'

Monocytes-Macrophage System

Macrophages secrete a vast range of biologically active substances into their

local milieu and to date, more than 50 substances secreted by macrophages

have been reported.

Enzymes; enzyme inhibitors; plasma proteins such as complement

components, coagulation factors, and apolipoprotein E; factors that regulate

the functions of other cells such as interferon, interleukin 1, mitogens, and

angiogenesis factor; and low molecular weight substances such as reactive

metabolites of oxygen and derivatives of arachidonic acids.
Monocytes-Causes of variation in Number

Monocytosis

Causes:

Monocytopenia

Causes:

Self Assessment

They are especially abundant in tissues that come into contact with the external

environment, such as mucosa of the

...............................................................................

MBP, ECP, EDN in eosinophils are important for .................................

(Bronchus) Cp permeability local site inflammation Wheezing, cough with

secretion, swollen bronchial lining and bronchoconstrictionDifficulty in breathing

(Bronchial Asthma). This is sequence for..............................action.
Self Assessment

Monocytes is ...........................% in blood and diameter is ..............................

............................... are important as antigen presenters cells to ......... Cells.

Formation of ..................................................occur in macrophages.

By osteoclast- .............................occurs to renew old bone from new bone

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