Download MBBS Physiology Presentations 59 Hematology Hb Synthesis Lecture Notes

Download MBBS (Bachelor of Medicine, Bachelor of Surgery) 1st Year, 2nd Year, 3rd Year and Final year Physiology 59 Hematology Hb Synthesis PPT-Powerpoint Presentations and lecture notes

Factors affecting Erythropoiesis and Hb synthesis

Learning Objectives

Factors affecting erythropoiesis

Hemoglobin synthesis


Factors regulating Erythropoiesis

Growth or Developmental Factors

Nutritional Factors

Hormonal Factors

Healthy Liver and Bone marrow

Hemopoietic Growth Factors - cytokines
Hemopoietic Growth Factors-EPO (Erythropoietin)

A glycoprotein hormone (mw 34000 d) and a cytokine
(protein signaling molecule)
for
erythrocyte precursors in the bone marrow.

90% from the kidney
10% form the liver

Nutritional Factors regulating Erythropoiesis

A) Proteins:
B) Minerals:
Iron (Fe++)
2. Copper (Cu++)
3. Cobalt (Co)


Nutritional Factors regulating Erythropoiesis

C) Vitamins:

Hormonal Factors regulating Erythropoiesis

Thyroid

Cortisol

Androgens


Regulation of Erythropoiesis - Liver and Bone marrow

Liver
Bone marrow

Hemoglobin

The hemoglobin is pigmented globular protein structure


Hemoglobin

Structure

Consists of 4 Subunits-

Heme group Globin chain

Function

Hemoglobin Synthesis

Heme synthesis starts in

Mitochondria of normoblast with

the condensation of

Glycine and Succinyl Coenzyme A


Hemoglobin Synthesis

Self Assessment

Which is not true for free Hb in blood-

a) it increase the blood viscosity

b) increase the osmotic/oncotic pressure

c) it can be lost by kidneys in urine

d) it damages the liver

Normal reticulocyte count at birth is-

a)1-2%

b)<1%

c)5-10%

d)2-6%

Erythropoietin is secreted from-

a)Kidney

b)Liver

c)tissue macrophage

d)spleen

life span of foetal RBC - a)120 days

b)120 weeks c) 80 days

d) 80 weeks