Download MBBS Physiology Presentations 59 Hematology Hb Synthesis Lecture Notes

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Factors affecting erythropoiesis

Hemoglobin synthesis

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Factors regulating Erythropoiesis

Growth or Developmental Factors

Nutritional Factors

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Hormonal Factors

Healthy Liver and Bone marrow

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Hemopoietic Growth Factors - cytokines
Hemopoietic Growth Factors-EPO (Erythropoietin)

A glycoprotein hormone (mw 34000 d) and a cytokine
(protein signaling molecule)

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for
erythrocyte precursors in the bone marrow.

90% from the kidney
10% form the liver

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Nutritional Factors regulating Erythropoiesis

A) Proteins:
B) Minerals:

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Iron (Fe++)
2. Copper (Cu++)
3. Cobalt (Co)

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Nutritional Factors regulating Erythropoiesis

C) Vitamins:

Hormonal Factors regulating Erythropoiesis

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Thyroid

Cortisol

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Androgens


Regulation of Erythropoiesis - Liver and Bone marrow

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Liver
Bone marrow

Hemoglobin

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The hemoglobin is pigmented globular protein structure


Hemoglobin

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Structure

Consists of 4 Subunits-

Heme group Globin chain

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Function

Hemoglobin Synthesis

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Heme synthesis starts in

Mitochondria of normoblast with

the condensation of

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Glycine and Succinyl Coenzyme A


Hemoglobin Synthesis

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Self Assessment

Which is not true for free Hb in blood-

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a) it increase the blood viscosity

b) increase the osmotic/oncotic pressure

c) it can be lost by kidneys in urine

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d) it damages the liver

Normal reticulocyte count at birth is-

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a)1-2%

b)<1%

c)5-10%

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d)2-6%

Erythropoietin is secreted from-

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a)Kidney

b)Liver

c)tissue macrophage

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d)spleen

life span of foetal RBC - a)120 days

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b)120 weeks c) 80 days

d) 80 weeks