--- Content provided by FirstRanker.com ---Ph.D Entrance Examination ? 06-Mar-2020
[Time: 90 Minutes]
[Max. Marks: 50 Marks]
FACULTY: PHARMACY
SUBJECT: PHARMACEUTICAL CHEMISTRY
PAPER ? II
Q.P. CODE: P002
Answer All The Questions
1.
Explain the structure and stability of carbocations.
2.
Discuss the therapeutic applications of Vitamin B1, Vitamin B2 and Folic acid.
With suitable examples, explain the mechanism of action of Alkylating agents and
antimetabolites as antineoplastic agents.
4.
Suggest the mechanism involved in Beckmann's rearrangements and Aldol condensation.
Discuss the concept of green chemistry with suitable examples.
6.
Discuss the retro synthesis with suitable example in medicinal chemistry.
7.
8.
Discuss the applications of microbial transformations with relevant examples.
9.
Write the structure and therapeutic applications of mutual prodrug `Amoxycillin and Clavulanic
acid''.
10. Explain the concept of `bioisosterism' and its applications in the drug discovery.
* * * * *
[Time: 90 Minutes]
--- Content provided by FirstRanker.com ---
--- Content provided by FirstRanker.com ---
--- Content provided by FirstRanker.com ---
[Max. Marks: 50 Marks]
--- Content provided by FirstRanker.com ---
FACULTY: PHARMACY
SUBJECT: PHARMACEUTICAL CHEMISTRY
--- Content provided by FirstRanker.com ---
PAPER ? II
Q.P. CODE: P002
--- Content provided by FirstRanker.com ---
Your answers should be specific to the Questions asked.Answer All The Questions
--- Content provided by FirstRanker.com ---
10 X 05 = 50 Marks1.
Explain the structure and stability of carbocations.
--- Content provided by FirstRanker.com ---
2.
Discuss the therapeutic applications of Vitamin B1, Vitamin B2 and Folic acid.
--- Content provided by FirstRanker.com ---
3.With suitable examples, explain the mechanism of action of Alkylating agents and
antimetabolites as antineoplastic agents.
--- Content provided by FirstRanker.com ---
4.
Suggest the mechanism involved in Beckmann's rearrangements and Aldol condensation.
--- Content provided by FirstRanker.com ---
5.Discuss the concept of green chemistry with suitable examples.
6.
--- Content provided by FirstRanker.com ---
Discuss the retro synthesis with suitable example in medicinal chemistry.
7.
--- Content provided by FirstRanker.com ---
Enumerate the adrenal cortex hormones with their therapeutic applications.8.
Discuss the applications of microbial transformations with relevant examples.
--- Content provided by FirstRanker.com ---
9.
Write the structure and therapeutic applications of mutual prodrug `Amoxycillin and Clavulanic
acid''.
--- Content provided by FirstRanker.com ---
10. Explain the concept of `bioisosterism' and its applications in the drug discovery.
--- Content provided by FirstRanker.com ---
* * * * *