KALOJI NARAYANA RAO UNIVERSITY OF
HEALTH SCIENCES
WARANGAL, TELANGANA STATE-506 002
MBBS SECOND YEAR DEGREE
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EXAMINATIONS: AUGUST, 2025PHARMACOLOGY
Paper-I
(NEW SCHEME)
Time: 3 Hours
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Max. Marks: 100Note! Answer all questions
Give Diagrammatic representation wherever nory
Multiple Choice Questions:
10 X 1 = 10
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1) Drug administered through the following route is mostlikely to be subjected to first-pass metabolism:
a) Oral
b) Sublingual
c) Subcutaneous
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d) Rectal2) Orphan drugs are
a) drugs with high therapeutic failure
c) drugs having low therapeutic margin
b) drugs for rare disease
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d) drugs with high toxicity
3) Low doses of aspirin prolong bleeding time by
selectively inhibiting synthesis of the following mediator
in the platelets:
a) Thromboxane A2
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b) 5-Hydroxytryptaminec) Platelet activating factor
d) Prostacyclin
4) The most effective drug in parkinsonism is:
a) Bromocriptine
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b) Selegilinec) Levodopa
d) Biperiden
5) The following analgesic lacks anti-inflammatory action
a) Paracetamol
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b) Ibuprofenc) Diclofenac sodium
d) Piroxicam
6) The drug which undergoes 'Hofmann' elimination is:
a) Succinylcholine
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b) Pancuroniumc) Vecuronium
d) Atracurium
7) fomepizole is used in which poisoning
a) methyl alcohol poisoning
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b) morphine poisoningc) strychnine poisoning
d) atropine poisoning.
8) Atropine poisoning causes all except
a) Dilated pupil
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b) Excessive salivationc) Excitement
d) hot skin
9) Antidote for paracetamol poisoning is
a) Naloxone
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b) Methylene bluec) N-acetylcysteine
d) Flumazenil
10) The drug of choice for status epilepticus is
a) Lorazepam
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b) Propofolc) Thiopentone
d) Sodium valproate
Essay/ Long Answer Questions:
2 X 15 = 30
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11) a) Enlist the different types of receptors withexamples of drugs acting through them. (6+2)
b) Describe the factors modifying drug action and their
clinical significance.
12) Classify Antidepressants. Describe the mechanism of
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action, therapeutic uses and adverse effects of TricyclicAntidepressants. (5+2)
Short Answer Questions:
7X6 = 42
13) Describe the advantages and disadvantages of
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Intravenous route of Drug administration.14) Compare and contrast Succinylcholine and D-
Tubocurarine.
15) Describe therapeutics uses and adverse effects of
Alpha Blockers.
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16) Classify Anticholinesterases and mention theirtherapeutic uses.
17) Explain the mechanisms of action, therapeutic uses
and adverse effects of proton Pump Inhibitors.
18) Describe disease modifying Anti Rheumatoid Drugs.
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19) Describe how to counsel HIV/ AIDS patient to adhereto Anti-Retroviral Therapy.
Very Short Answer Questions:
6X3 = 18
20) Define Prodrug with two examples.
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21) Enlist any two uses of Adrenaline with its rationale.22) Mention the drugs used in the management of Organo
Phosphorous Poisoning with its rationale.
23) Mention three different groups of drugs used in
Bronchial Asthma with one example for each.
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24) What is Malignant Hyperthermia? Mention the drugused for its treatment.
25) Define Tachyphylaxis. Give two examples of drugs
causing Tachyphylaxis.
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