MBBS SECOND YEAR DEGREE
SUPPLEMENTARY EXAMINATIONS: JUNE,
2025
PHARMACOLOGY
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Paper -ITime: 3 Hours
Max Marks: 100
Note: Answer all questions
Give Diagrammatic representation wherever necessary
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Multiple Choice Questions:10 X 1 = 10
1) A prodrug is:
a) the prototype member of a class of drugs
b) the oldest member of a class of drugs
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c) an inactive drug that is transformed in the body to anactive metabolite
d) that drug stored in body tissues and released
gradually in the circulation
2) The antiasthma drug which cannot be administered by
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inhalation route is:a) Theophylline
c) Ketamine
b) Budesonide
d) Ipratropium bromide
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e) Propofol
f) Terbutaline
3) Dissociative anaesthesia' is produced by:
b) Fentanyl
d) Both A & B
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4) Which is the most important drug in the treatment oforganophosphorus poisoning:
a) Atropine sulfate
c) Diazepam
b) Atenolol
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d) Adrenaline5) Carbamazepine is not used in-
a) Mania
c) Trigeminal neuralgia
b) Partial seizure
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d) Migraine6) Among the disease modifying anti-rheumatic drugs,
fastest symptom relief is obtained with:
a) Auranofin
c) Sulfasalazine
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b) Hydroxychloroquined) Methotrexate
7) Drugs having both alpha and beta agonist property
a) Propranolol
c) dopamine
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b) Adrenalined) Diazepam
8) Which of the following adrenergic agents increases
peripheral vascular resistance
a) Noradrenaline
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c) Isoprenalineb) Adrenaline
d) None of the above
9) Orphan drugs are
a) drugs for rare disease
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c) drugs having low therapeutic marginb) drugs with high therapeutic failure
d) drugs with high toxicity
10) Which of the following is used as nasal decongestant
a) Clonidine
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c) Norepinephrineb) Dobutamine
d) Oxymetazoline
Essay/ Long Answer Questions:
2 X 15 = 30
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11.a) Define Biotransformation. Describe theconsequences of Biotransformation reactions with
examples. (2+6)
b) Define Enzyme induction and describe its clinical
significance.
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(2+5)Short Answer Questions:
7 X 6 = 42
12. Classify Antiparkinsonian Drugs. Describe the
mechanism of action and adverse effects of Levodopa.
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Enlist the benefits of combining Levodopa withCarbidopa. (6+3+3+3)
13. Define apparent Volume of distribution. Describe its
clinical significance.
14. Compare and contrast Benzodiazepines and
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Barbiturates.15. Enlist atropine substitutes and their Therapeutic uses.
16. Describe the drugs used in the treatment of Cough.
17. Explain the mechanism of action, therapeutic uses
and adverse effects of Ondansetron.
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18. Enlist Prostaglandin Analogues. Describe theirTherapeutics uses.
19. Describe how to motivate patients with coronary
artery disease to adhere to the prescribed treatment of the
physician.
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Very Short Answer Questions:6 X 3 = 18
20. Define Teratogenicity with two examples.
21. Mention the drugs used in the management of
Myasthenia Gravis with its rationale.
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22. Enlist any two Inhalational Corticosteroids used inBronchial Asthma with their advantages.
23. Mention three drugs used in generalised Tonic Clonic
Seizures.
24. Define Pharmacogenetics. Give two examples.
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25. Mention three advantages of using aluminiumHydroxide and Magnesium Hydroxide as antacid
combination.