Download KNRUHS MBBS 1st Year Biochemistry Paper I Feb 2024 Question Paper

MBBS FIRST YEAR SUPPLEMENTARY
EXAMINATIONS: FEBRUARY/MARCH 2024
BIOCHEMISTRY (New Regulation)
PAPER-1
Time: 3 Hours

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Max. Marks: 100
Note: Answer all questions
Draw diagrams whenever necessary with Black Ball point
pen/HB pencil/any dark Colour pencil
Multiple Choice Questions: 10 X 1=10

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1. Volume expander in treatment of hypovolemia
a) Dextrins
b) Dextran
c) Heparin
d) Agarose

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2. Pyruvate is converted to acetyl CoA. by
a) Pyruvate dehydrogenase
c) Pyruvate kinase
b) Pyruvate Carboxylase
d) Lactate dehydrogenase

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3. The presence of the following fatty acid in diet
prevents heart attacks
a) Eicosa trienoic acid
c) Eicosa pentaenoic acid
b) Eicosa tetranoic acid

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d) None of the above
4. Prostaglandins are stored
a) In adipose tissue
b) As plasma lipoproteins
c) As membrane phospholipid

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d) As granules in mast cells
5. All the following enzyme complexes of respiratory
chain act as proton pumps except
a) Complex I
c) Complex III

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b) Complex II
d) Complex IV
6. The enzyme involved in the transfer of electrons are
known as
a) Oxidoreductases

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c) Lyases
b) Transferases
d) All of the above
7. Symport system operates in the transport of
a) Bicarbonate

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c) Calcium
b) Chloride
d) Glucose
8. The following diseases are peroxisomal biogenesis
disorders except

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a) Adrenoleukodystrophy
c) Primary Hyperoxaluria

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b) Zellweger syndrome
d) Inclusion cell disease
9. The separation of molecules based on their size, shape

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and molecular weight is done by
a) lon-exchange Chromatography
c) Adsorption chromatography
b) Gel filtration chromatography
d) Affinity chromatography

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10. All the following coenzymes are derivatives of B-
complex vitamins, except
a) S-adenosyl methionine
c) Pyridoxal phosphate
b) NAD+

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d) Coenzyme A
Essay/ Long Answer Questions: 2 X 15=30
11. How the Fatty acids are oxidized in the body. Explain
B-oxidation, give its energetics and explain the regulation
of B-oxidation in the body. 30

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12. An 8-year-old child was brought to the hospital with
e/o slow growth and pain in bones. On examination, he
was anaemic had frontal bossing, bowing of legs and
swelling of costochondral junction. Laboratory results
were serum calcium - 8.2mg/dl, serum ALP: 720 U/L,

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serum phosphorous - 2.8mg/dl.
a) What is your diagnosis.
b) What are the biochemical effects of vitamin D.
c) Causes for vitamin D deficiency.

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d). Sources and RDA vitamin D.

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e) What are the clinical features of vitamin D deficiency.
30
Short Answer Questions: 7X6=42
13. Describe the Hexose Mono Phosphate shunt path way
and add a note on its significance. 6

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14. What is Substrate Level Phosphorylation and explain
with suitable examples. 6
15. Clinically important enzymes and their significance.
6
16. Mucopolysaccharides. 6

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17. Write about Anti-oxidants and their role in health. 6
18. How does the Physician improves the Health Care
System. 6
19. Absorption of iron and its regulation. 6
Very Short Answer Questions: 6X3=18

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20. Dietary fiber. 3
21. What is Michaelis Menten (Km) value. Explain the
concept by using suitable example. 3
22. Glycosuria and Renal Glycosuria. 3
23. Structure and functions of Lipoprotein. 3

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24. Rethera's test. 3
25. Mention the clinical features of the following
diseased conditions;
a. Keshan disease

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b. Wilson's disease

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c. Hemosiderosis. 3
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