KALOJI NARAYANA RAO UNIVERSITY OF
HEALTH SCIENCES
MBBS FIRST YEAR EXAMINATIONS:
SEPTEMBER 2025
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WARANGAL, TELANGANA STATE-506002BIOCHEMISTRY
PAPER - II
(NEW SCHEME)
Time: 3 Hours
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Max. Marks: 100Note: Answer all questions
Give Diagrammatic representation wherever necessary
Multiple Choice Questions: 10 X 1=10
1) Pulses are deficient in
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a) Lysinec) Methionine
b) Threonine
d) Tryptophan
2) Which one of the following theories effectively
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explains the feature of immune response?a) Selection theory
c) Template theory
b) Germ line theory
d) Clonal selection theory
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3) Chronic obstructive airway disease results in
a) Respiratory acidosis
c) Respiratory alkalosis
b) Metabolic acidosis
d) Metabolic alkalosis
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4) A hormone secreted from anterior pituitary isa) Growth hormone
c) Oxytocin
b) Vasopressin
d) Epinephrine
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5) Molecules involved in immune response area) MHC molecules
c) Chemokines
b) Cytokines
d) All the above
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6) Antioxidant enzymes area) Superoxide dismutase (SOD)
c) Glutathione peroxidase
b) Catalase
d) All the above
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7) Biotransformation takes place ina) Intestines
c) Skin
b) Lungs
d) Liver
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8) Serum acid phosphatase level increases ina) Carcinoma of Prostate
c) Carcinoma of Liver
b) Carcinoma of Lung
d) Carcinoma of Oesophagus
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9) The predominant buffer system of plasma is thea) Albumin buffer
c) Haemoglobin buffer
b) Bicarbonate buffer
d) Phosphate buffer
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10) The Peptide that protects RBC membrane isa) Oxytocin
c) Vasopressin
b) Glutathione
d) Angiotensin
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Write an essay on the following. 2 X 15 = 3011) Discuss the metabolism of Glycine. Give an account
on biological important compounds synthesised from
Glycine. Add a note on primary Hyperoxaluria. (8+4+3)
12) A 45-year-old obese lady presented to the causality
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with complaints of acute right upper abdominal pain, mildfever, loss of appetite and generalized itching. On further
questioning, she gave history of frothy, clay coloured stool
and high coloured urine.
a) What is the probable diagnosis?
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b) Mention the laboratory tests you advise to confirmthe diagnosis?
c) Describe the normal bilirubin metabolism.
d) How do you relate the high coloured urine, itching
and clay-coloured stools with altered metabolic pathway
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of bilirubin in this condition.(1+2+6+6)
Write a short essay on the following: 7 X 6 = 42
13) Describe the Oncogenes and their role in Cancer with
examples.
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14) Discuss the Renal mechanisms involved in regulationof blood pH.
15) Recombinant DNA technology and its applications.
16) What are your perspectives on lifelong learning by
Physician?
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17) Discuss the structure of normal Haemoglobin. Add anote on haemoglobin derivatives.
18) What is Transamination and its significance? List two
Transaminases.
19) Structure and functions of t-RNA.
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Write briefly on the following: 6 X 3 = 1820) DNA polymerase.
21) Alkaptonuria.
22) What is the normal anion gap? State its importance.
23) Phase II detoxification.
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24) Point mutation.25) Porphyria Cutanea tarda.
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