Madhya Pradesh Medical Science University, Jabalpur
MBBS Second Professional Examination April-2024
Subject- Pharmacology
Paper- I (new scheme)
Time: 3:00 Hours
Instructions:
a) Al questions are compulsory
b) Draw diagrams wherever necessary
d) MCQ has to be answered in theory answer book
e) Please write MCQ answer neatly and in serial order with black or blue pen in brackets; for example: - 1. (a) 2. (c)
f)
MCQ has to be answered only once, any kind of repetition or cutting or erasing or whitener wil be considered as malpractice, such answers wil not be
g) Subjective answer should be answered in up to 30 words per marks. For example, if a question having 2 marks should answered in up to 60 marks.
Q1. Total MCQs: 10
10 x 1 = 10
Medical Practitioner only"?
(a) Schedule H
(b) Schedule X
(c) Schedule Y
2. Essential medicines are those medicines:
(a) That are needed to
(b) That are needed to
(c) That satisfy the priority (d) That are introduced
treat serious diseases
health care needs of the
recently into the market
conditions
3. Which of the fol owing agent is beneficial in NSAID induced gastric ulcer?
(a) PGE1 agonist
(b) PGE2 agonist
(c) PGD2 agonist
4. The success of oral rehydration therapy of diarrhea, depends upon which of the fol owing process in the
intestinal mucosa?
(a) Na+ absorption by Na+ (b) Glucose coupled Na+
(c) Bicarbonate coupled
absorption
Na+ absorption
diffusion secondary to
nutrient absorption
(a) Membrane stabilizing
(b) Retinal neuron
(c) Decrease production of (d) Pupil ary constriction
effect
aqueous humor
6. A 24-years-old farm worker is rushed to emergency department after an accidental exposure to parathion.
Which of the fol owing drugs can be given to increase the activity of his acetyl cholinesterase?
(a) Atropine
(c) Physostigmine
(d) Pralidoxime
7. Drug used in treatment of torsade de pointes:
(a) Quinidine
(c) Isoprenaline
(d) Verapamil
8. In a patient with hypertriglyceridemia and low HDL, which of the fol owing drug wil be best without risk of
myocardial side effect?
(b) Nicotinic acid
(c) Atorvastatin
(d) Clofibrate
9. A patient of bronchial asthma was prescribed 2 puffs from a metered dose inhaler of budesonide. Which of the
(a) Shake the inhaler wel
(b) Clean the inhaler after
(c) Wait for 1 minute in
(d) Rinse mouth after
every use
between puffs
every use
10. A 30 years old pregnant woman has a history of rheumatoid arthritis which has been managed successful y
worsened by food intake. Which of the fol owing ulcer Medications is most likely contraindicated in this patient?
(a) Famotidine
(b) Omeprazole
(c) Misoprostol
Q2. Long Answer Questions
2 x 20 = 40
a. A 35-year-old woman was taking combined oral contraceptive pil s. She was diagnosed as a case of Pulmonary
tuberculosis and put on isoniazid, rifampicin, pyrazinamide and ethambutol combination therapy daily for 2
failed to have withdrawal bleeding during the gap period of contraceptive cycle. Later her urinary pregnancy
test was found positive.
I What is the reason for contraceptive failure?
II Explain Phase I biotransformation reaction with suitable examples.
IV Explain microsomal enzyme inhibition with suitable examples.
b. A 70 years old male presented with complaints of weak stream of urine, sense of incomplete voiding and
increased urinary frequency. On physical examination and ultrasound, he was diagnosed as having benign
prostatic hyperplasia.
II What is the rationale of using these drugs in benign prostatic hyperplasia (BPH).
III Write down the mechanism of action and common side effects of these drugs.
IV What is the role of finasteride in the treatment of benign prostatic hyperplasia (BPH)
Q3. Brief Answer Questions
a. Enumerate Proton pump inhibitors with their therapeutic uses. Mention first line Anti H. pylori regimen.
b. Treatment of status asthmaticus.
c. Enumerate parenteral iron preparations. Mention in which condition iron therapy be administered by
injection route.
e. Classify loop diuretics. Enumerate therapeutic uses and adverse effects of loop diuretics.
f. Classify various dosage forms of drug. Write in brief about Tablets.
Q4. Short Answer Questions
10 x 2 = 20
b. Post marketing surveil ance study.
c. Enumerate 02 differences between first and zero order kinetics.
d. Explain, why low dose of aspirin is used for myocardial infarction?
e. Name two anti-secretory anti motility drug for treatment of diarrhea.
preparations.
g. Enumerate 2 drugs used in the treatment of productive cough.
h. Role of nitrates in cyanide poisoning.
i. Enumerate 04 therapeutic uses of Fibrinolytics.
MBBS Second Professional Examination April-2024
Subject- Pharmacology
Paper- I (new scheme)
Time: 3:00 Hours
--- Content provided by FirstRanker.com ---
Maximum Marks :100Instructions:
a) Al questions are compulsory
b) Draw diagrams wherever necessary
--- Content provided by FirstRanker.com ---
c) Answers of Questions and Sub-questions must be written strictly according to serial order of question paper.d) MCQ has to be answered in theory answer book
e) Please write MCQ answer neatly and in serial order with black or blue pen in brackets; for example: - 1. (a) 2. (c)
f)
MCQ has to be answered only once, any kind of repetition or cutting or erasing or whitener wil be considered as malpractice, such answers wil not be
--- Content provided by FirstRanker.com ---
counted in marks and action wil be taken according to UFM rules of university.g) Subjective answer should be answered in up to 30 words per marks. For example, if a question having 2 marks should answered in up to 60 marks.
Q1. Total MCQs: 10
10 x 1 = 10
--- Content provided by FirstRanker.com ---
1. For which of the fol owing drugs a warning is written "To be sold by retail on the prescription of a RegisteredMedical Practitioner only"?
(a) Schedule H
(b) Schedule X
(c) Schedule Y
--- Content provided by FirstRanker.com ---
(d) Schedule J2. Essential medicines are those medicines:
(a) That are needed to
(b) That are needed to
(c) That satisfy the priority (d) That are introduced
--- Content provided by FirstRanker.com ---
treat emergencytreat serious diseases
health care needs of the
recently into the market
conditions
--- Content provided by FirstRanker.com ---
population3. Which of the fol owing agent is beneficial in NSAID induced gastric ulcer?
(a) PGE1 agonist
(b) PGE2 agonist
(c) PGD2 agonist
--- Content provided by FirstRanker.com ---
(d) PGF2a agonist4. The success of oral rehydration therapy of diarrhea, depends upon which of the fol owing process in the
intestinal mucosa?
(a) Na+ absorption by Na+ (b) Glucose coupled Na+
(c) Bicarbonate coupled
--- Content provided by FirstRanker.com ---
(d) Passive sodiumabsorption
Na+ absorption
diffusion secondary to
nutrient absorption
--- Content provided by FirstRanker.com ---
5. The most important action of beta-blockers in glaucoma is which of the fol owing:(a) Membrane stabilizing
(b) Retinal neuron
(c) Decrease production of (d) Pupil ary constriction
effect
--- Content provided by FirstRanker.com ---
protecting effectaqueous humor
6. A 24-years-old farm worker is rushed to emergency department after an accidental exposure to parathion.
Which of the fol owing drugs can be given to increase the activity of his acetyl cholinesterase?
(a) Atropine
--- Content provided by FirstRanker.com ---
(b) Dimercaprol(c) Physostigmine
(d) Pralidoxime
7. Drug used in treatment of torsade de pointes:
(a) Quinidine
--- Content provided by FirstRanker.com ---
(b) Amiodarone(c) Isoprenaline
(d) Verapamil
8. In a patient with hypertriglyceridemia and low HDL, which of the fol owing drug wil be best without risk of
myocardial side effect?
--- Content provided by FirstRanker.com ---
(a) Fibric acid derivatives(b) Nicotinic acid
(c) Atorvastatin
(d) Clofibrate
9. A patient of bronchial asthma was prescribed 2 puffs from a metered dose inhaler of budesonide. Which of the
--- Content provided by FirstRanker.com ---
fol owing should NOT be done?(a) Shake the inhaler wel
(b) Clean the inhaler after
(c) Wait for 1 minute in
(d) Rinse mouth after
--- Content provided by FirstRanker.com ---
before useevery use
between puffs
every use
10. A 30 years old pregnant woman has a history of rheumatoid arthritis which has been managed successful y
--- Content provided by FirstRanker.com ---
with NSAIDs. However, she has recently visited her general practitioner complaining of burning epigastric painworsened by food intake. Which of the fol owing ulcer Medications is most likely contraindicated in this patient?
(a) Famotidine
(b) Omeprazole
(c) Misoprostol
--- Content provided by FirstRanker.com ---
(d) RanitidineQ2. Long Answer Questions
2 x 20 = 40
a. A 35-year-old woman was taking combined oral contraceptive pil s. She was diagnosed as a case of Pulmonary
tuberculosis and put on isoniazid, rifampicin, pyrazinamide and ethambutol combination therapy daily for 2
--- Content provided by FirstRanker.com ---
months fol owed by isoniazid and rifampicin thrice weekly for 4 months. In the 3rd month of treatment, shefailed to have withdrawal bleeding during the gap period of contraceptive cycle. Later her urinary pregnancy
test was found positive.
I What is the reason for contraceptive failure?
II Explain Phase I biotransformation reaction with suitable examples.
--- Content provided by FirstRanker.com ---
II Explain Microsomal Enzyme Induction.IV Explain microsomal enzyme inhibition with suitable examples.
b. A 70 years old male presented with complaints of weak stream of urine, sense of incomplete voiding and
increased urinary frequency. On physical examination and ultrasound, he was diagnosed as having benign
prostatic hyperplasia.
--- Content provided by FirstRanker.com ---
I Enumerate 05 drugs used in the treatment of benign prostatic hyperplasia (BPH).II What is the rationale of using these drugs in benign prostatic hyperplasia (BPH).
III Write down the mechanism of action and common side effects of these drugs.
IV What is the role of finasteride in the treatment of benign prostatic hyperplasia (BPH)
Q3. Brief Answer Questions
--- Content provided by FirstRanker.com ---
6 x 05 = 30a. Enumerate Proton pump inhibitors with their therapeutic uses. Mention first line Anti H. pylori regimen.
b. Treatment of status asthmaticus.
c. Enumerate parenteral iron preparations. Mention in which condition iron therapy be administered by
injection route.
--- Content provided by FirstRanker.com ---
d. Classify Anti-Hypertensive Drugs. Enumerate drug used in hypertension during pregnancy.e. Classify loop diuretics. Enumerate therapeutic uses and adverse effects of loop diuretics.
f. Classify various dosage forms of drug. Write in brief about Tablets.
Q4. Short Answer Questions
10 x 2 = 20
--- Content provided by FirstRanker.com ---
a. Enumerate 04 therapeutic uses of central y acting skeletal muscle relaxants.b. Post marketing surveil ance study.
c. Enumerate 02 differences between first and zero order kinetics.
d. Explain, why low dose of aspirin is used for myocardial infarction?
e. Name two anti-secretory anti motility drug for treatment of diarrhea.
--- Content provided by FirstRanker.com ---
f. Explain pharmacological basis of combination of Calcium and Magnesium salts in most of antacidpreparations.
g. Enumerate 2 drugs used in the treatment of productive cough.
h. Role of nitrates in cyanide poisoning.
i. Enumerate 04 therapeutic uses of Fibrinolytics.
--- Content provided by FirstRanker.com ---
j. Mechanism of action of osmotic diuretics.