Madhya Pradesh Medical Science University, Jabalpur
MBBS Second Professional Examination June-2023
Subject- Pharmacology
Time: 3:00 Hours
Paper- I (old scheme)
Instructions:
a) Al questions are compulsory
b) Draw diagrams wherever necessary
d) MCQ has to be answered in theory answer book
e) Please write MCQ answer neatly and in serial order with black or blue pen in brackets; for example: - 1. (a) 2. (c)
f)
MCQ has to be answered only once, any kind of repetition or cutting or erasing or whitener wil be considered as malpractice, such answers wil not be
g) Subjective answer should be answered in up to 30 words per marks. For example, if a question having 2 marks should answered in up to 60 marks.
Q1. Total MCQs: 16
16 x 1/2 = 8
(a) Biochemical alteration of
(b) Drug metabolites are
(c) Movement of drug from
(d) The drug causes receptor
removed in the urine
the gut into general
stimulation and response
circulation
(a) Increased cyclic AMP
(b) Decreased cyclic GMP
(c) Decreased IP3
(d) Calcium influx
(a) Beta blocker
(b) Alpha blocker
(c) Alpha agonist
(d) Muscarinic blocker
wel control ed previously. Infusion of low dose edrophonium elicits a significant improvement in her muscle strength. Which of
the fol owing is the best next step in the management of this patient?
(a) Increase neostigmine
(b) Administer pralidoxime
(d) Add low dose propranolol
dosage
temporarily
5. Which of the fol owing is the drug of choice for essential hypertension with benign prostatic hyperplasia (BPH)?
(b) Prazosin
(c) Neostigmine
(d) Dopamine
6. Which of the fol owing is most likely to occur with the use of this beta blocker?
(b) Bronchoconstriction,
(c) Urination, diarrhea, and
(d) Migraine headaches,
hypotension, and
mydriasis
hypertension, and tocolysis
hyperglycemia
hyperlipidemia
7. Which of the fol owing antihistamines would be the MOST appropriate treatment for a 32-year-old airline pilot who has a
long history of seasonal allergic rhinitis and complains of postnasal drainage, coughing, and throat irritation?
(a) Diphenhydramine
(b) Fexofenadine
(d) Chlorpheniramine
8. A diuretic which acts in the thick ascending loop of the nephron would cause:
(a) Hyporeninemia,
(b) Hypercalcemia,
(d) Hypokalemia,
hyperkalemia, and
hyperlipidemia, hypokalemia, hypokalemia, and metabolic
hypomagnesemia, and
and hyperuricemia
acidosis
preferential vasodilation in
renal vasculature
started. Twenty-five minutes later, she starts bleeding profusely from the intravenous site. The heparin is stopped, but the
bleeding continues. The attending physician decides to give a counteragent to the adverse effect of heparin. What drug was
given?
(a) Factor XII
(c) Protamine sulfate
(d) Vitamin K
10. A class of anti-anginal medications with multiple mechanisms of action that include: decreased preload, decreased oxygen
demand, decreased afterload (at high doses), and increased myocardial oxygen delivery by dilating large epicardial arteries.
(b) Calcium channel blocker
(c) Nitrate
(d) Anti-platelet drug
11. In a 32-year-old woman with a long history of bronchial asthma, the use of mometasone aerosol for treatment is likely to
(a) Diabetes mellitus
(b) Essential hypertension
(c) Truncal obesity
(d) Voice hoarseness
Which drug was used in this case?
(a) Buspirone
(b) Cyproheptadine
(c) Ondansetron
13. A 54-year-old man is being treated for peptic ulcer disease and subsequently develops gynecomastia. Which of the
fol owing drugs is he most likely taking?
(a) Cimetidine
(b) Misoprostol
(d) Ranitidine
14. A new drug has been developed with the fol owing characteristics: when 100 mg of the drug is injected, 95 mg remains
after 2 hours, 90 mg remains after 4 hours, and 85 mg remains after 6 hours. This drug shows elimination properties similar to
which of the fol owing drugs in high doses?
(b) Clonidine
(c) Morphine
(d) Propranolol
15. Neostigmine wil effectively antagonize skeletal muscle relaxation produced by:
(b) Succinylcholine
(c) Diazepam
(d) Baclofen
16. A 42-year-old male with an acute MI is given streptokinase. What is the mechanism of action of streptokinase?
(b) Antagonism of ADP
(c) Glycoprotein IIb/IIIa
(d) Activation of plasminogen
thromboxane production
antagonist
to plasmin
Q2. Long Answer Questions
2 x 5 = 10
and explain the underlying pharmacological mechanism of therapeutic benefits for each of those uses.
Enumerate 4 adverse effects of ACEIs.
b. Classify drugs used in Peptic Ulcer Disease. Write the mechanism of action, uses, and adverse effects of
Proton Pump Inhibitors (PPIs). Mention one drug regimen for the treatment of Helicobacter pylori infection.
4 x 3 = 12
a. Enumerate Low Molecular Weight Heparins (LMWHs). Write advantages of LMWHs in comparison to
Unfractionated Heparin.
b. Compare and contrast between Zero-order and First-order kinetics of drug elimination.
d. Enumerate uses of adrenaline and discuss the management of anaphylactic shock.
Q4. Short Answer Questions
10 x 1 = 10
a. Mention 4 factors that can alter the apparent volume of distribution of a drug.
combinations available in the market.
c. Explain the pharmacological basis of the combination of Hydrochlorothiazide and Triamterene.
d. Enumerate 2 drugs each for acute and long-term treatment of Migraine.
e. Enumerate 2 drugs belonging to two different groups used in the treatment of hypertensive emergency.
preparations.
g. Write 2 examples of competitive antagonists.
h. Enumerate 2 drugs used in the treatment of productive cough.
i. Name one important drug interaction of sildenafil citrate.
MBBS Second Professional Examination June-2023
Subject- Pharmacology
Time: 3:00 Hours
Paper- I (old scheme)
--- Content provided by FirstRanker.com ---
Maximum Marks :40Instructions:
a) Al questions are compulsory
b) Draw diagrams wherever necessary
--- Content provided by FirstRanker.com ---
c) Answers of Questions and Sub-questions must be written strictly according to serial order of question paper.d) MCQ has to be answered in theory answer book
e) Please write MCQ answer neatly and in serial order with black or blue pen in brackets; for example: - 1. (a) 2. (c)
f)
MCQ has to be answered only once, any kind of repetition or cutting or erasing or whitener wil be considered as malpractice, such answers wil not be
--- Content provided by FirstRanker.com ---
counted in marks and action wil be taken according to UFM rules of university.g) Subjective answer should be answered in up to 30 words per marks. For example, if a question having 2 marks should answered in up to 60 marks.
Q1. Total MCQs: 16
16 x 1/2 = 8
--- Content provided by FirstRanker.com ---
1. Which of the fol owing is a PHARMACODYNAMIC process?(a) Biochemical alteration of
(b) Drug metabolites are
(c) Movement of drug from
(d) The drug causes receptor
--- Content provided by FirstRanker.com ---
the drug by liver enzymesremoved in the urine
the gut into general
stimulation and response
circulation
--- Content provided by FirstRanker.com ---
2. Which out of the fol owing is the mechanism by which this adrenoceptor agonist produced bronchodilation?(a) Increased cyclic AMP
(b) Decreased cyclic GMP
(c) Decreased IP3
(d) Calcium influx
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3. Topical administration to the eye of which of the fol owing agents is likely to induce mydriasis and cycloplegia?(a) Beta blocker
(b) Alpha blocker
(c) Alpha agonist
(d) Muscarinic blocker
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4. A patient on neostigmine therapy for Myasthenia gravis complains of progressive fatigue and diplopia who was otherwisewel control ed previously. Infusion of low dose edrophonium elicits a significant improvement in her muscle strength. Which of
the fol owing is the best next step in the management of this patient?
(a) Increase neostigmine
(b) Administer pralidoxime
--- Content provided by FirstRanker.com ---
(c) Stop neostigmine(d) Add low dose propranolol
dosage
temporarily
5. Which of the fol owing is the drug of choice for essential hypertension with benign prostatic hyperplasia (BPH)?
--- Content provided by FirstRanker.com ---
(a) Propranolol(b) Prazosin
(c) Neostigmine
(d) Dopamine
6. Which of the fol owing is most likely to occur with the use of this beta blocker?
--- Content provided by FirstRanker.com ---
(a) Bronchodilation,(b) Bronchoconstriction,
(c) Urination, diarrhea, and
(d) Migraine headaches,
hypotension, and
--- Content provided by FirstRanker.com ---
hyperglycemia, andmydriasis
hypertension, and tocolysis
hyperglycemia
hyperlipidemia
--- Content provided by FirstRanker.com ---
(uterine relaxation)7. Which of the fol owing antihistamines would be the MOST appropriate treatment for a 32-year-old airline pilot who has a
long history of seasonal allergic rhinitis and complains of postnasal drainage, coughing, and throat irritation?
(a) Diphenhydramine
(b) Fexofenadine
--- Content provided by FirstRanker.com ---
(c) Promethazine(d) Chlorpheniramine
8. A diuretic which acts in the thick ascending loop of the nephron would cause:
(a) Hyporeninemia,
(b) Hypercalcemia,
--- Content provided by FirstRanker.com ---
(c) Hyperglycemia,(d) Hypokalemia,
hyperkalemia, and
hyperlipidemia, hypokalemia, hypokalemia, and metabolic
hypomagnesemia, and
--- Content provided by FirstRanker.com ---
hypermagnesemiaand hyperuricemia
acidosis
preferential vasodilation in
renal vasculature
--- Content provided by FirstRanker.com ---
9. A 49-year-old female with post-surgical deep-vein thrombosis (DVT) is given a bolus of heparin, and a heparin drip is alsostarted. Twenty-five minutes later, she starts bleeding profusely from the intravenous site. The heparin is stopped, but the
bleeding continues. The attending physician decides to give a counteragent to the adverse effect of heparin. What drug was
given?
(a) Factor XII
--- Content provided by FirstRanker.com ---
(b) Aspirin(c) Protamine sulfate
(d) Vitamin K
10. A class of anti-anginal medications with multiple mechanisms of action that include: decreased preload, decreased oxygen
demand, decreased afterload (at high doses), and increased myocardial oxygen delivery by dilating large epicardial arteries.
--- Content provided by FirstRanker.com ---
(a) Beta blocker(b) Calcium channel blocker
(c) Nitrate
(d) Anti-platelet drug
11. In a 32-year-old woman with a long history of bronchial asthma, the use of mometasone aerosol for treatment is likely to
--- Content provided by FirstRanker.com ---
produce which of the fol owing?(a) Diabetes mellitus
(b) Essential hypertension
(c) Truncal obesity
(d) Voice hoarseness
--- Content provided by FirstRanker.com ---
12. A patient undergoing cancer chemotherapy is administered an antiemetic agent that is an antagonist at the 5HT3 receptor.Which drug was used in this case?
(a) Buspirone
(b) Cyproheptadine
(c) Ondansetron
--- Content provided by FirstRanker.com ---
(d) Sumatriptan13. A 54-year-old man is being treated for peptic ulcer disease and subsequently develops gynecomastia. Which of the
fol owing drugs is he most likely taking?
(a) Cimetidine
(b) Misoprostol
--- Content provided by FirstRanker.com ---
(c) Omeprazole(d) Ranitidine
14. A new drug has been developed with the fol owing characteristics: when 100 mg of the drug is injected, 95 mg remains
after 2 hours, 90 mg remains after 4 hours, and 85 mg remains after 6 hours. This drug shows elimination properties similar to
which of the fol owing drugs in high doses?
--- Content provided by FirstRanker.com ---
(a) Aspirin(b) Clonidine
(c) Morphine
(d) Propranolol
15. Neostigmine wil effectively antagonize skeletal muscle relaxation produced by:
--- Content provided by FirstRanker.com ---
(a) Pancuronium(b) Succinylcholine
(c) Diazepam
(d) Baclofen
16. A 42-year-old male with an acute MI is given streptokinase. What is the mechanism of action of streptokinase?
--- Content provided by FirstRanker.com ---
(a) Inhibition of platelet(b) Antagonism of ADP
(c) Glycoprotein IIb/IIIa
(d) Activation of plasminogen
thromboxane production
--- Content provided by FirstRanker.com ---
receptorantagonist
to plasmin
Q2. Long Answer Questions
2 x 5 = 10
--- Content provided by FirstRanker.com ---
a. Enumerate 4 commonly prescribed Angiotensin Converting Enzyme Inhibitors (ACEIs). Write 4 uses of ACEIsand explain the underlying pharmacological mechanism of therapeutic benefits for each of those uses.
Enumerate 4 adverse effects of ACEIs.
b. Classify drugs used in Peptic Ulcer Disease. Write the mechanism of action, uses, and adverse effects of
Proton Pump Inhibitors (PPIs). Mention one drug regimen for the treatment of Helicobacter pylori infection.
--- Content provided by FirstRanker.com ---
Q3. Brief Answer Questions4 x 3 = 12
a. Enumerate Low Molecular Weight Heparins (LMWHs). Write advantages of LMWHs in comparison to
Unfractionated Heparin.
b. Compare and contrast between Zero-order and First-order kinetics of drug elimination.
--- Content provided by FirstRanker.com ---
c. Write the mechanism of action, uses, adverse effects, and contraindications of Osmotic diuretics.d. Enumerate uses of adrenaline and discuss the management of anaphylactic shock.
Q4. Short Answer Questions
10 x 1 = 10
a. Mention 4 factors that can alter the apparent volume of distribution of a drug.
--- Content provided by FirstRanker.com ---
b. Explain the pharmacological basis of the combination of adrenaline and lignocaine in most local anestheticcombinations available in the market.
c. Explain the pharmacological basis of the combination of Hydrochlorothiazide and Triamterene.
d. Enumerate 2 drugs each for acute and long-term treatment of Migraine.
e. Enumerate 2 drugs belonging to two different groups used in the treatment of hypertensive emergency.
--- Content provided by FirstRanker.com ---
f. Explain the pharmacological basis of the combination of Calcium and Magnesium salts in most antacidpreparations.
g. Write 2 examples of competitive antagonists.
h. Enumerate 2 drugs used in the treatment of productive cough.
i. Name one important drug interaction of sildenafil citrate.
--- Content provided by FirstRanker.com ---
j. Name a drug for Paroxysmal Supraventricular Tachycardia.