Madhya Pradesh Medical Science University, Jabalpur
MBBS Second Professional Examination January-2025
Subject- Microbiology
Paper- I (new scheme)
Time: 3:00 Hours
Instructions:
a) Al questions are compulsory
b) Draw diagrams wherever necessary
d) MCQ has to be answered in theory answer book
e) Please write MCQ answer neatly and in serial order with black or blue pen in brackets; for example: - 1. (a) 2. (c)
f)
MCQ has to be answered only once, any kind of repetition or cutting or erasing or whitener wil be considered as malpractice, such answers wil not be
g) Subjective answer should be answered in up to 30 words per marks. For example, if a question having 2 marks should answered in up to 60 marks.
Q1. Total MCQs: 10
10 x 1 = 10
(a) Clostridium tetani
(b) Escherichia coli
(c) Pseudomonas
(d) None of the above
2. The most important specimen for isolation of Salmonel a Typhi in first week of enteric fever is
(a) Blood
(b) Faeces
(c) Urine
3. Patch test is done for which type of reaction?
(a) Schwartzman reaction
(b) Atopy
(c) Arthus reaction
4. Which of the fol owing are responsible for hyperacute rejection?
(a) Preformed antibodies
(b) In-situ antibody
(c) Lymphokines
formation
5. Fasciola hepatica infects
(a) Liver
(b) Bile duct
6. Eschar is a pathognomonic feature of -
(a) Typhus fever
(b) Scrub typhus
(c) Q fever
7. The route of administration of measles vaccine is
(a) Intramuscular
(b) Intradermal
(c) subcutaneous
8. Tol -like receptors (TLRs) are -
(a) Present on surface of
(b) Transmembrane
(c) Molecules that bind to
phagocytes to bind to
receptors present on
the surface of microbes
oligomerization domain
surface of macrophages
like receptors to recognize
and dendritic cel s
intracel ular bacterial cel
9. Passive immunization of hepatitis B infection is good for -
(a) Control ing adverse
(b) Prevention of carrier
(c) Control ing the spread
reactions
state
of disease
10. The fol owing substances can be added to produce an anaerobic environment except -
(b) Ascorbic acid
(c) Cysteine
(d) Glycerol
2 x 20 = 40
a. A 6-year-old boy came to the pediatric OPD for school health check-up. On examination he had pal or.
Peripheral blood examination revealed microcytic, hypochromic anaemia. Stool microscopy showed round to
oval non-bile-stained egg with segmented ovum (four blastomeres).
Identify the etiological agent responsible for this condition?
II.
Enlist the microorganisms causing iron deficiency anaemia.
III.
IV.
Describe the pathogenesis.
V.
Mention the diagnostic modalities available for this clinical condition.
gradual y over 10 days. He was admitted with complaints of loss of appetite, pain in abdomen and general
weakness. On examination he was found to have a temperature of 102?F with pal or and coated tongue,
relative bradycardia, mild splenomegaly and abdominal tenderness. His hemogram showed low TLC count,
leukopenia with relative lymphocytosis. His blood culture was positive and non-lactose fermenting colonies
positive, negative for indole, citrate and urease and HS gas was produced with K/A reaction on TSI agar.
I.
What is your probable diagnosis and etiological agent responsible for this condition?
II.
III.
Mention the diagnostic modalities available for this condition including the sample col ection methods.
IV.
Add a note on the treatment and vaccine available for this clinical condition.
Add a note on drug resistance for this clinical condition.
Q3. Brief Answer Questions
6 x 05 = 30
a. Steam sterilization
c. Classical complement pathway
d. Mention the methods to demonstrate and functions of bacterial capsule.
e. Describe transferable drug resistance.
f. Chikungunya
10 x 2 = 20
a. Enumerate Diarrheagenic E.coli
b. Draw wel label ed diagram of IgA
c. Enlist two parasitic causes of -- splenomegaly and cholangitis.
e. Laboratory diagnosis of fungal infections.
f. Enumerate two advantages of live vaccine.
g. Mention four differences between MHC class I and MHC class II.
h. Mention four difference between endotoxin and exotoxin.
j. Name the four rules of autonomy
MBBS Second Professional Examination January-2025
Subject- Microbiology
Paper- I (new scheme)
Time: 3:00 Hours
--- Content provided by FirstRanker.com ---
Maximum Marks :100Instructions:
a) Al questions are compulsory
b) Draw diagrams wherever necessary
--- Content provided by FirstRanker.com ---
c) Answers of Questions and Sub-questions must be written strictly according to serial order of question paper.d) MCQ has to be answered in theory answer book
e) Please write MCQ answer neatly and in serial order with black or blue pen in brackets; for example: - 1. (a) 2. (c)
f)
MCQ has to be answered only once, any kind of repetition or cutting or erasing or whitener wil be considered as malpractice, such answers wil not be
--- Content provided by FirstRanker.com ---
counted in marks and action wil be taken according to UFM rules of university.g) Subjective answer should be answered in up to 30 words per marks. For example, if a question having 2 marks should answered in up to 60 marks.
Q1. Total MCQs: 10
10 x 1 = 10
--- Content provided by FirstRanker.com ---
1. Culture medium with low redox potential is required for the growth of:(a) Clostridium tetani
(b) Escherichia coli
(c) Pseudomonas
(d) None of the above
--- Content provided by FirstRanker.com ---
aeruginosa2. The most important specimen for isolation of Salmonel a Typhi in first week of enteric fever is
(a) Blood
(b) Faeces
(c) Urine
--- Content provided by FirstRanker.com ---
(d) Pus3. Patch test is done for which type of reaction?
(a) Schwartzman reaction
(b) Atopy
(c) Arthus reaction
--- Content provided by FirstRanker.com ---
(d) Contact dermatitis4. Which of the fol owing are responsible for hyperacute rejection?
(a) Preformed antibodies
(b) In-situ antibody
(c) Lymphokines
--- Content provided by FirstRanker.com ---
(d) Al of the theseformation
5. Fasciola hepatica infects
(a) Liver
(b) Bile duct
--- Content provided by FirstRanker.com ---
(c) Both liver and bile duct (d) Smal intestine6. Eschar is a pathognomonic feature of -
(a) Typhus fever
(b) Scrub typhus
(c) Q fever
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(d) Spotted fever7. The route of administration of measles vaccine is
(a) Intramuscular
(b) Intradermal
(c) subcutaneous
--- Content provided by FirstRanker.com ---
(d) Oral8. Tol -like receptors (TLRs) are -
(a) Present on surface of
(b) Transmembrane
(c) Molecules that bind to
--- Content provided by FirstRanker.com ---
(d) Nucleotide-bindingphagocytes to bind to
receptors present on
the surface of microbes
oligomerization domain
--- Content provided by FirstRanker.com ---
mannose rich glycanssurface of macrophages
like receptors to recognize
and dendritic cel s
intracel ular bacterial cel
--- Content provided by FirstRanker.com ---
products9. Passive immunization of hepatitis B infection is good for -
(a) Control ing adverse
(b) Prevention of carrier
(c) Control ing the spread
--- Content provided by FirstRanker.com ---
(d) Prevention of infectionreactions
state
of disease
10. The fol owing substances can be added to produce an anaerobic environment except -
--- Content provided by FirstRanker.com ---
(a) Glutathione(b) Ascorbic acid
(c) Cysteine
(d) Glycerol
--- Content provided by FirstRanker.com ---
Q2. Long Answer Questions2 x 20 = 40
a. A 6-year-old boy came to the pediatric OPD for school health check-up. On examination he had pal or.
Peripheral blood examination revealed microcytic, hypochromic anaemia. Stool microscopy showed round to
oval non-bile-stained egg with segmented ovum (four blastomeres).
--- Content provided by FirstRanker.com ---
I.Identify the etiological agent responsible for this condition?
II.
Enlist the microorganisms causing iron deficiency anaemia.
III.
--- Content provided by FirstRanker.com ---
Describe the life cycle.IV.
Describe the pathogenesis.
V.
Mention the diagnostic modalities available for this clinical condition.
--- Content provided by FirstRanker.com ---
b. A 12 years old male child was admitted in the pediatric ward with a history of remittent fever which increasedgradual y over 10 days. He was admitted with complaints of loss of appetite, pain in abdomen and general
weakness. On examination he was found to have a temperature of 102?F with pal or and coated tongue,
relative bradycardia, mild splenomegaly and abdominal tenderness. His hemogram showed low TLC count,
leukopenia with relative lymphocytosis. His blood culture was positive and non-lactose fermenting colonies
--- Content provided by FirstRanker.com ---
were isolated from MacConkey agar. On further identification, it was found to be oxidase negative, catalasepositive, negative for indole, citrate and urease and HS gas was produced with K/A reaction on TSI agar.
I.
What is your probable diagnosis and etiological agent responsible for this condition?
II.
--- Content provided by FirstRanker.com ---
Describe the pathogenesis.III.
Mention the diagnostic modalities available for this condition including the sample col ection methods.
IV.
Add a note on the treatment and vaccine available for this clinical condition.
--- Content provided by FirstRanker.com ---
V.Add a note on drug resistance for this clinical condition.
Q3. Brief Answer Questions
6 x 05 = 30
a. Steam sterilization
--- Content provided by FirstRanker.com ---
b. What is ful disclosure? Mention the exceptional conditions where ful disclosure is not made.c. Classical complement pathway
d. Mention the methods to demonstrate and functions of bacterial capsule.
e. Describe transferable drug resistance.
f. Chikungunya
--- Content provided by FirstRanker.com ---
Q4. Short Answer Questions10 x 2 = 20
a. Enumerate Diarrheagenic E.coli
b. Draw wel label ed diagram of IgA
c. Enlist two parasitic causes of -- splenomegaly and cholangitis.
--- Content provided by FirstRanker.com ---
d. NACO Strategic algorithm IIa and IIb for HIV.e. Laboratory diagnosis of fungal infections.
f. Enumerate two advantages of live vaccine.
g. Mention four differences between MHC class I and MHC class II.
h. Mention four difference between endotoxin and exotoxin.
--- Content provided by FirstRanker.com ---
i. Staging of vaccine vial monitor.j. Name the four rules of autonomy