Download RGUHS MBBS 2nd Year 1029 Pharmacology Paper II Aug 2025 Question Paper

QP CODE : 1029
Rajiv Gandhi University of Health Sciences, Karnataka
MBBS Phase ? II (CBME) Degree Examination - 20-Aug-2025
Time: Three Hours
Max. Marks: 100

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PHARMACOLOGY ? PAPER II (RS-4, RS-5 & RS-6)
Q.P. CODE: 1029
(QP contains two pages)
Your answers should be specific to the questions asked
Draw neat, labeled diagrams wherever necessary

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LONG ESSAYS
2 x 10 = 20 Marks
1.
Mention four Aminoglycoside antibiotics. Explain their common properties, mechanism of
action and adverse effects.

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2.
A 69-year-old man presents to the hospital with increasing fatigue, shortness of breath and
swelling of lower extremities. A diagnosis of Heart Failure was made.
a) Mention three groups of drugs with suitable examples used in Heart failure.
b) Write the mechanism of action and adverse effects of any one of the drugs used.

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SHORT ESSAYS
8 x 5 = 40 Marks
3.
A 10-year-old boy with fever and sore throat was prescribed Azithromycin. Describe
mechanism of action, antibacterial spectrum and uses of Azithromycin.

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4.
Discuss the therapeutic uses of Glucocorticoids.
5.
Write the mechanism of action, adverse effects and uses of Alendronate.
6.

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Write the mechanism of action, adverse effects and uses of Vinca alkaloids.
7.
A 55-year-old patient was diagnosed with new onset Type 2 Diabetes mellitus.
a) Mention two classes of Oral antidiabetic drugs with suitable examples that can be
prescribed to this patient.

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b) Describe mechanism of action and adverse effects of any one class of drug.
8.
Write the mechanism of action, adverse effects and uses of Clomiphene citrate.
9.
Discuss the drug therapy of Myocardial infarction.

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10.
Write the mechanism of action, uses and adverse effects of Loop Diuretics.
SHORT ANSWERS
10 x 3 = 30 Marks
11.

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Mention three drugs used in the management of Hypertensive emergencies
12.
Mention three Uses of Acetazolamide
13.
Mention three advantages of Low molecular weight Heparin

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14.
Write two uses of Methotrexate. Explain the reason for using Folinic acid in Methotrexate
toxicity
15.
Explain the reasons for combining Ceftazidime with Tazobactam

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16.
Mention three drugs used in Lepra reaction with reasons
17.
Mention three Protease inhibitors used in the treatment of HIV infection
18.

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Write three measures to reduce development of antimicrobial resistance
19.
Write two uses of penicillin G. Why is it not preferred in Gram negative bacterial infection?
20.
Mention three Live attenuated vaccines

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QP CODE : 1029
Rajiv Gandhi University of Health Sciences, Karnataka
Multiple Choice Questions
10 x 1 = 10 Marks

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21 i)
The Long acting Insulin preparation producing a smooth peakless effect is
A. Glargine
B. Lispro
C. Aspart

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D. Glulisine
21 ii)
Anastrozole inhibits which of the following enzyme to produce its therapeutic effect
A. Transpeptidase
B. DNA Polymerase

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C. Aromatase
D. Ribonucleotide reductase
21 iii)
The drug used in Angina pectoris which dilates the coronary arteries is
A. Nitroglycerine

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B. Metoprolol
C. Ivabradine
D. Trimetazidine
21 iv) Which of the following is contraindicated in the treatment of pregnancy induced
hypertension?

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A. Enalapril
B. Alpha methyl dopa
C. Labetalol
D. Hydralazine
21 v)

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Absorption of oral iron preparations can be facilitated by co-administration of
A. Antacids
B. Tetracycline
C. Ascorbic acid
D. Calcium

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22 i)
Which of the following is an adverse effect of Atorvastatin
A. Retinopathy
B. Gout
C. Thromboembolism

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D. Myopathy
22 ii)
The objectives of using antimicrobial combinations are
A. To achieve synergism
B. To prevent emergence of resistance

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C. To broaden the antimicrobial spectrum
D. All of the above
22 iii)
A patient receiving an antimicrobial agent since a week for amoebiasis, had dizziness,
flushing and vomiting after drinking alcohol. Which of the following drugs most likely

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caused this interaction with alcohol
A. Imipenem
B. Levfloxacin
C. Griseofulvin
D. Metronidazole

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22 iv) The anticancer drug that is not derived from plant source is
A. Irinotecan
B. Vincristine
C. Doxorubicin
D. Paclitaxel

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22 v)
The potassium channel opener used for treatment of Alopecia is
A. Nicorandil
B. Diazoxide
C. Cromakalim

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D. Minoxidil
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