Rajiv Gandhi University of Health Sciences, Karnataka
MBBS Phase ? II (CBME) Degree Examination - 19-Nov-2025
Time: Three Hours
Max. Marks: 100
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PATHOLOGY ? PAPER I (RS-4, RS-5 & RS-6)Q.P. CODE: 1026
(QP contains two pages)
Your answers should be specific to the questions asked
Draw neat, labeled diagrams wherever necessary
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LONG ESSAYS2 x 10 = 20 Marks
1.
30-year female admitted to emergency with high grade fever, hypotension, weak, rapid
pulse, tachypnea and cold, clammy, cyanotic skin. Blood culture showed gram negative
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bacteria. She succumbed due to dysfunction in multiple organs.a) What is the likely diagnosis?
b) Discuss the etiopathogenesis of this condition.
c) Describe the morphology of organs involved.
2.
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30-year male vegetarian and chronic gastritis patient was evaluated for the pallor,paresthesia of extremities.
a) What is the type of anemia?
b) Discuss the etiopathogenesis and pathology associated with this condition
c) Add a note on laboratory investigations in the work up of this patient.
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SHORT ESSAYS8 x 5 = 40 Marks
3.
Laboratory diagnosis of systemic lupus erythematosus
4.
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Differences between necrosis and apoptosis.5.
Describe the sequential steps in cutaneous wound healing.
6.
List the actions of Arachidonic acid metabolites in inflammation.
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7.Role of Exfoliative cytology.
8.
Paraneoplastic syndromes.
9.
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Opportunistic infection associated with AIDS.10.
Discuss the pathophysiology of sickle cell anemia.
SHORT ANSWERS
10 x 3 = 30 Marks
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11.Sputum findings in Bronchial asthma.
12.
Cytochemical stains used in Acute leukemia.
13.
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Qualitative platelet defects.14.
Aplastic anemia.
15.
Enumerate the blood products available for transfusion.
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16.List six examples for metaplasia
17.
Amyloid spleen.
18.
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Rickets.19.
List the causes associated with variation in urine specific gravity
20.
List the manifestations of syphilis.
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Multiple Choice Questions10 x 1 = 10 Marks
21 i)
Which of the following is DNA repair defect?
A. Retinoblastoma
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B. NeurofibromatosisC. Xeroderma pigmentosum
D. MEN-I
Page 1 of 2
QP CODE : 1026
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Rajiv Gandhi University of Health Sciences, Karnataka21 ii)
Type III Hypersensitivity reaction is seen in all EXCEPT
A. Post streptococcal Glomerulonephritis
B. Good Pasteur's syndrome
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C. Systemic lupus erythematosusD. Rheumatoid arthritis
21 iii)
Nut meg liver is seen in all conditions EXCEPT
A. Hepatic venous congestion.
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B. Right heart failureC. Budd chiari syndrome
D. Reye's syndrome
21 iv) Dystrophic calcification is seen in all EXCEPT
A. Old healed tuberculosis
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B. Damaged heart valvesC. Fat necrosis
D. Chronic kidney failure
21 v)
In Marfan's syndrome there is defect in protein
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A. DystrophinB. Spectrin
C. Fibrillin
D. Ankyrin
22 i)
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Which of the following is a feature of Disseminated Intravascular Coagulation (DIC)?A. Normal prothrombin time
B. Reduced plasma fibrinogen
C. Normal platelet count
D. Normal clotting time
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22 ii)Carcinoembryonic antigen is elevated in all, EXCEPT
A. Carcinoma pancreas
B. Carcinoma colon
C. Carcinoma stomach
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D. Carcinoma prostate22 iii)
7-year-old girl presents with haematoma in the thigh. She has prolonged APTT, normal
PT and platelet count. This is due to deficiency of any of the factor EXCEPT
A. Factor IX
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B. Factor VIIIC. Factor VII
D. Factor XI
22 iv) Which of the following is NOT a poor prognostic factor in Acute Lymphoblastic
Leukemia?
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A. Presence of t (9:22)B. Age < 2 years
C. Hyperploidy
D. Peripheral blood blast count >1 lakh
22 v)
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Autoimmune hemolytic anemia is seen in:A. Acute Lymphoblastic Leukemia
B. Acute Myeloblastic Leukemia
C. Chronic Lymphocytic Leukemia
D. Chronic Myeloid Leukemia
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