Download NTRUHS MBBS Pathology Paper I Jan 2012 Question Paper

Q.P. CODE: [INSERT CODE HERE]
DR NTR UNIVERSITY OF HEALTH SCIENCES ::
VIJAYAWADA-8
M.B.B.S. DEGREE EXAMINATION - JANUARY, 2012
SECOND M.B.B.S. EXAMINATION

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PATHOLOGY
(GENERAL PATHOLOGY & HAEMATOLOGY)
PAPER-I
Time: 2 Hours
Max. Marks: 40

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Note: Answer all questions. Give diagrammatic
representation wherever possible.
1) A 4 years old male child presented with fatigue, fever,
epistaxis,
bleeding gums, bone pain and CNS manifestations from

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meningeal
involvement. Physical examination revealed petechiae and
ecchymoses of skin and mucous membranes, generalized
lymphadenopathy and testicular enlargement. The
leukocyte and

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differential counts were abnormal. 1+4+3+3=10
a) What is the provisional diagnosis?
b) Discuss various main laboratory investigations to make
a
final diagnosis.

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c) Describe peripheral blood and bone marrow picture.
d) Discuss molecular pathogenesis of the disease.
WRITE SHORT NOTES ON:
5 x 4 = 20

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5 x 4 = 20

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2) Role of Selectins and Integrins involved in the
inflammatory
response.
3) von Willebrand disease.
4) Systemic Thrombo embolism.

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5) Physical and chemical nature of Amyloid
6) Important growth factors modulating tumor growth and
biology.
WRITE BRIEFLY ON:
5 x 2 = 10

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7) Barr bodies.
8) Autophagy.
9) Skeletal changes in Rickets.
10) Late manifestations of congenital Syphilis.
11) Frozen section.

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