DR NTR UNIVERSITY OF HEALTH SCIENCES ::
VIJAYAWADA-8
M.B.B.S. DEGREE EXAMINATION - JANUARY, 2011
SECOND M.B.B.S. EXAMINATION
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PATHOLOGY(GENERAL PATHOLOGY & HAEMATOLOGY)
PAPER-I
Time: 2 Hours
Max. Marks: 40
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Note: Answer all questions. Give diagrammaticrepresentation wherever possible.
1) A homosexual individual who is also an intravenous
drug abuser with history of persistent generalized
lymphadenopathy (PGL) and chronic diarrhea came to
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sexually transmitted diseases (STD) OPD with mucosalcandidiasis, fever, oral hairy leukoplakia and loss of
more than 10% body weight. There is a fall in CD4+ T
cells count.
a) What is the provisional diagnosis?
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b) Describe the sequences of events in the pathogenesisof the disease.
c) Discuss various tests used for diagnosis and for
monitoring treatment of the same. 10
WRITE SHORT NOTES ON:
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5 x 4 = 202) Paraneoplastic syndromes.
3) Peripheral smear and bone marrow picture in
megaloblastic anemia.
4) Growth factors involved in tissue regeneration and
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repair.5) Haematocrit.
6) Arachidonic acid metabolites and their role in
inflammation.
WRITE BRIEFLY ON:
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5 x 2 = 107) Phlebothrombosis.
8) Clinical features and karyotypes of Turner Syndrome.
9) Mode of action of anticoagulants.
10) Pathogenesis of dystrophic calcification.
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11) Name four tumor suppressor genes.***