Download BFUHS MBBS MBN105 Biochemistry A Mar 2022 mcq Question Paper

Total No. = 03 pages


Q.P. Code: MBN105
M.B.B.S. 1st Prof.

--- Content provided by FirstRanker.com ---

(New Scheme w.e.f. 2019 admission onwards)
BF/2022/06
Biochemistry ? A

M.M. : 100

--- Content provided by‍ FirstRanker.com ---

Time : 3 Hours(First30 Min. for MCQs)
Note: 1.
Use OMR Sheet to answer Multiple Choice Questions(MCQs).
2.
Attempt all questions. Illustrate your answers with suitable diagrams

--- Content provided by​ FirstRanker.com ---

3.
NO SUPPLEMENTARY SHEET SHALL BE ALLOWED/PROVIDED
4.
The student must write Q.P. Code in the space provided on OMR Sheet and the Title
page of the Answer Book.

--- Content provided by‍ FirstRanker.com ---

Q.1
MCQs (Attempt on OMR sheet)
[1x20]
1.
A 4 year old boy presented with epicanthal fold, strabismus and mental retardation. On urine

--- Content provided by‌ FirstRanker.com ---

examination, ferric chloride test was positive and mousy odor smell. There was history of
seizures, eczema and limb spasticity. Name the clinical condition.
a.
Phenyl ketonuria
b.

--- Content provided by‍ FirstRanker.com ---

Cystinuria
c.
Homocystinuria
d.
Alkaptonuria

--- Content provided by‍ FirstRanker.com ---

2.
Bacterial synthesis of folic acid by the human intestinal flora is inhibited when sulphonamides
is administered. Identify the type of inhibition.
a.
Allosteric inhibition

--- Content provided by FirstRanker.com ---

b.
Non-competitive inhibition
c.
Competitive inhibition
d.

--- Content provided by FirstRanker.com ---

Enzyme poisoning
3.
A girl accidently ingests lead paint and develops acute abdominal pain, tingling sensations of
hands and legs along with weakness. Which enzyme is inhibited in this child?
a.

--- Content provided by FirstRanker.com ---

ALA synthase
b.
Heme oxygenase
c.
Coproporphyrinogen oxidase d.

--- Content provided by FirstRanker.com ---

ALA dehydratase
4.
Biologically active sugars are in the D configuration such as D-Glucose and D-Galactose. D-
configuration means:
a.

--- Content provided by‌ FirstRanker.com ---

All the OH groups are on the right side.
b.
The OH group at C1 is on the right side
c.
The OH group on the penultimate carbon is on the right side.

--- Content provided by⁠ FirstRanker.com ---

d.
The OH grou
p on C3 is on the right side always.
5.
Liver uses glucose at a significant rate only when blood glucose levels are elevated . This is

--- Content provided by⁠ FirstRanker.com ---

due to the following EXCEPT
a.
Insulin increases the transcription of glucokinase gene.
b.
Insulin induces the uptake of glucose by GLUT-2 across the liver parenchymal cells.

--- Content provided by⁠ FirstRanker.com ---

c.
Km of glucokinase is considerably greater than normal blood glucose concentration.
d.
Glucokinase is not inhibited by glucose-6 phosphate
6.

--- Content provided by‌ FirstRanker.com ---

Cadiolipins are composed of the following-
a.
Glycerol, choline and phosphoric acid
b.
Glycerol, fatty acids and phosphoric acid

--- Content provided by​ FirstRanker.com ---

c.
Glycerol, inositol and phosphoric acid
d.
Glycerol, serine and phosphoric acid
Page 1 of 3

--- Content provided by​ FirstRanker.com ---

---

7.
Zellweger syndrome is a rare autosomal recessive condit
ion, characterized by early mortality i

--- Content provided by‍ FirstRanker.com ---

n
childhood. It is caused by:
a.
Mitochondrial degradation b.
Defective formation of peroxisomes

--- Content provided by FirstRanker.com ---

c.
Break up of the cell wall
d.
Absence of ribosomes
8.

--- Content provided by⁠ FirstRanker.com ---

The respiratory chain of the mitochondria has many complexes. The component of the
respiratory chain that reacts directly with molecular oxygen is:
a.
Cyt b
b.

--- Content provided by‌ FirstRanker.com ---

Cyt c
c.
CoQ
d.
Cyt aa3

--- Content provided by​ FirstRanker.com ---

9.
Estimation of the activity of isoenzymes of Creatine phosphokinase in serum is useful in the
differential diagnosis of:
a.
Muscle and heart diseases

--- Content provided by⁠ FirstRanker.com ---

b.
Muscle and liver diseases
c.
Liver and heart diseases
d.

--- Content provided by⁠ FirstRanker.com ---

Liver and kidney diseases
10.
A lady presented with tingling sensation in legs and hands along with lesions in the angle of
mouth with red tongue. On investigation, glutathione reductase activity was found to be low.
She is suffering from deficiency of which vitamin?

--- Content provided by⁠ FirstRanker.com ---

a.
Riboflavin
b.
Pyridoxine
c.

--- Content provided by FirstRanker.com ---

Vitamin B12
d.
Folic Acid
11.
Glycosaminoglycans (GAGs) have many biological functions in our body. Identify the GAG

--- Content provided by⁠ FirstRanker.com ---

which is responsible for corneal transparency.
a.
Keratan sulphate
b.
Heparin sulphate

--- Content provided by‌ FirstRanker.com ---

c.
Chondroitin sulphate
d.
Hyaluronic acid
12.

--- Content provided by‍ FirstRanker.com ---

The pyruvate dehyrogenase complex (PDH complex) brings about the conversion of pyruvate
to acetyl CoA. Which combination of cofactors is involved in this important reaction?
a.
NAD+ , biotin and TPP
b.

--- Content provided by⁠ FirstRanker.com ---

TPP, lipoic acid and NAD+
c.
Pyridoxal phosphate, FAD and lipoic acid
d.
Biotin, FAD and TPP

--- Content provided by FirstRanker.com ---

13.
Galactosemia is a rare, hereditary disorder of carbohydrate metabolism that affects the body's
ability to convert galactose to glucose. The classical Galactosemia is due to the deficiency of:
a.
Hexosaminidase

--- Content provided by‍ FirstRanker.com ---

b.
Glucocerebrosidase
c.
Sphingomyelinase
d.

--- Content provided by‌ FirstRanker.com ---

Galactose-1-phosphate uridyl transferase
14.
Which of the following is the essential fatty acid in the human diet?
a.
Oleic acid

--- Content provided by⁠ FirstRanker.com ---

b.
Palmitic acid
c.
Linolenic acid
d.

--- Content provided by‍ FirstRanker.com ---

Arachidic acid
15.
Vitamins are essential
for proper functioning of certain metabolic pathways.The conversion of
Propionyl CoA to Succinyl CoA requires two vitamins. They are:

--- Content provided by‍ FirstRanker.com ---

a.
Thiamin and Riboflavin
b.
Thiamine and Biotin
c.

--- Content provided by‌ FirstRanker.com ---

Biotin and Vitamin B12
d.
Vitamin B12 and Folic acid
16.
An anti-inflammatory substance that inhibits cyclooxygenase enzyme and prevents the

--- Content provided by‌ FirstRanker.com ---

synthesis of prostaglandins is :
a.
Sulphadiazine
b.
Paracetamol

--- Content provided by FirstRanker.com ---

c.
Penicillin
d.
Aspirin
17.

--- Content provided by‌ FirstRanker.com ---

Refsum's disease is characterized by accumulation of phytanic acid in the body. This is due to
defect of:
a.
Alpha-oxidation
b.

--- Content provided by‌ FirstRanker.com ---

Beta- oxidation
c.
Omega oxidation
d.
Deficiency of Endoplasmic reticulum

--- Content provided by​ FirstRanker.com ---

Page 2 of 3

---

18.
Which of the following lipoprotein will be elevated in the

--- Content provided by⁠ FirstRanker.com ---

blood stream after intake of meals
in
a patient with lipoprotein lipase deficiency?
a.
Chylomicron

--- Content provided by⁠ FirstRanker.com ---

b.
Non esterified fatty acids
c.
Low density lipoprotein
d.

--- Content provided by‍ FirstRanker.com ---

High density lipoprotein
19.
The secondary structure of proteins is formed by alpha helical structure and beta pleated sheet.
The bonds stabilizing them are:
a.

--- Content provided by⁠ FirstRanker.com ---

Disulphide bonds
b.
Hydrophobic bonds
c.
Hydrogen bonds

--- Content provided by‌ FirstRanker.com ---

d.
Electrostatic bonds
20.
The only amino acid that undergoes oxidative deamination to a significant extent and liberates
free ammonia, which is then further metabolized to urea is :

--- Content provided by​ FirstRanker.com ---

a.
Aspartic acid
b.
Glutamic acid
c.

--- Content provided by​ FirstRanker.com ---

Valine
d.
Methionine
Q.2. A new born baby had severe abdominal distention, abdominal pain and diarrhea after being fed
breast milk. Stool analysis revealed the presence of reducing sugar.

--- Content provided by‌ FirstRanker.com ---

a.
What is your diagnosis?
b.
What is the enzyme defect and what is the biochemical basis of the symptoms of the
newborn.

--- Content provided by‌ FirstRanker.com ---

c.
Enumerate different reducing sugars. Which out of them is most likely present in the
stool of the newborn?
d.
How can it be treated?

--- Content provided by​ FirstRanker.com ---

[2+4+3+3]
Q.3. Write short notes on:-
[5x4]
a.
Epimers and amomers

--- Content provided by FirstRanker.com ---

b.
Essential fatty acids
c.
Liposomes and its significance
d.

--- Content provided by​ FirstRanker.com ---

One carbon pool
Q.4. Explain why:-
[3x5]
a.
Blood collection tube containing sodium fluoride is used to collect specimen for blood

--- Content provided by FirstRanker.com ---

glucose estimation.
b.
Sulpha drugs are avoided in patients with G6PD deficiency
c.
Homocysteinurea/Homocystinurea is a risk factor for CAD

--- Content provided by‌ FirstRanker.com ---

d.
Some amount of glucose is required by adipose tissue for its normal function
e.
Urine turns black on standing in patient with alkaptonuria
Q.5. Write short notes on (applied aspect):-

--- Content provided by‍ FirstRanker.com ---

[6x3]
a.
Discuss the antioxidant role of various vitamins
b.
Describe ammonia transport with reasons of hyperamnonemia. Why ammonia is toxic

--- Content provided by​ FirstRanker.com ---

for body?
c.
Discuss the role of enzymes in health and disease.
Q.6. Write short notes:-
[5x3]

--- Content provided by​ FirstRanker.com ---

a.
Discuss briefly the -oxidation of palmitic acid along with its energetics.
b.
Discuss various inhibitors of electron transport chain along with their site of inhibition.
c.

--- Content provided by‌ FirstRanker.com ---

Discuss the boundaries of doctor-patient relationship.
-------------------
Page 3 of 3

---