Total No. = 04 pages
Q.P. Code: MBN201
M.B.B.S. 2nd Prof.
(New Scheme w.e.f. 2019 admission onwards)
BF/2022/06
M.M. : 100
Time : 3 Hours(First 30 Min. for MCQs)
Note: 1.
2.
Attempt all questions. Illustrate your answers with suitable diagrams
3.
NO SUPPLEMENTARY SHEET SHALL BE ALLOWED/PROVIDED
The student must write Q.P. Code in the space provided on OMR Sheet and the Title page of
the Answer Book.
Q.1
MCQs (Attempt on OMR sheet)
1. A 16-year-old girl undergoes radiologic imaging of her abdomen and is found to have only one kidney.
She had been entirely unaware of this problem. Which of the following terms is most descriptive of
this finding?
a. Agenesis
Atrophy
c. Hyperplasia
d.
Hypoplasia
of his peripheral blood reveals a normochromic, normocytic anemia, along with a decreased number of
platelets and an increased number of white blood cells. Coagulation studies reveal prolonged
prothrombin and partial thromboplastin time with bone marrow examination revealing blast like cells
with numerous Auer rods. These immature cells make up about 38% of the nucleated cells in the
a. Acute lymphoblastic leukemia
b. Acute monocytic leukemia
c. Acute myelomonocytic leukemia d. Acute promyelocytic leukemia
3. A 40-year M, presented with fever and cough. His TLC is 1,00,000/cu.mm; DLC: Neutrophils- 80%;
a.
CML
b.
AML-M3
Leukemoid reaction
d.
MDS
4. A 30-year-old woman presents with a painless nodular swelling on her right ear lobe. She reports that
Histopathology showed dense hyalinised collagen with fibroblasts and myofibroblasts. Which of the
following best explains the pathogenesis of this lesion?
a. Clonal expansion of smooth muscle cells
b. Exuberant formation of granulation tissue
d. Maturation arrest of collagen assembly
5. A 22-year-old male patient asks for advice regarding seasonal eye itching and runny nose. Recurrent
conjunctivitis in this patient is most likely caused by which of the following mechanisms of disease?
a. Autoimmunity
Bacterial infection
c. Chemical toxicity
d.
Hypersensitivity
excision the tissue is sent to pathology lab with label "lipoma of the cord." The pathology resident
examines the tissue and infers that it's not a neoplastic lipoma, but instead is nonneoplastic normal
adipose tissue. Which one of the following features could best differentiate a benign well-
differentiated lipoma from normal adipose tissue?
b.
Clonal proliferation
c. Numerous mitoses
d.
Page 1 of 4
7. A 33-year-old woman discovers a lump in her left breast on self-examination. Her mother and sister
both had breast cancer. Needle aspiration reveals the presence of malignant, ductal epithelial cells.
Genetic screening identifies a mutation in BRCA1. In addition to cell cycle control, BRCA1 protein
a. Apoptosis
b.
Cell adhesion
c. DNA repair
Gene transcription
8. A 58-year-old man with a 3-pack-per day smoking history presents to the emergency department with
shortness of breath and hemoptysis. Portable chest radiography demonstrates a large mass centrally
located within the left lung field. The serum calcium is 13.0 mg/dL (normal 8.5 to 10.2). The
a. Adrenocorticotropic hormone?like substance
b. Antidiuretic hormone
c.
Carcinoembryonic antigen
9. Few men on years long trip on a ship developed some kind of disease and finally died. Months later, a
rescue team finds the bodies of the men. All have a hyperkeratotic, papular rash; ecchymoses; and
severe gingival swelling with hemorrhages. Which of the following was most likely a contributing
cause of death in these men?
b.
Kwashiorkor
c. Pellagra
d.
10. A 36-year-old man dies during cardiac surgery. He had a history of long-standing rheumatic heart
disease with mitral stenosis. At autopsy, the pathologist reports findings consistent with mitral stenosis
and noted the presence of "heart failure cells." This finding results from
a. activation of the coagulation cascade.
c. hypoxic myocardial injury.
d. myocardial hyperemia.
11. A 32-year-old woman gives birth at 34 weeks' gestation to a markedly hydropic stillborn male infant.
Autopsy findings include hepatosplenomegaly and cardiomegaly, serous effusions in all body cavities,
hematopoiesis in visceral organs. Which of the following hemoglobins is most likely predominant on
hemoglobin electrophoresis of the fetal RBCs?
a. Hemoglobin A1
b.
c. Hemoglobin Bart's
d.
Hemoglobin E
12. A 6yrs old child belonging to Punjabi family with past history of blood transfusions presented with
anemia with target cell and reduced osmotic fragility. What is the probable diagnosis of patient?
a. Alpha thalassemia
b.
Beta thalassemia
d.
G6PD deficiency
13. A 67-year-old man presents with increasing fatigue and is found to be anemic. Physical examination
reveals a hard 1-cm nodule in the left lobe of the prostate. The prostatic-specific antigen (PSA) level is
erythrocytes are mainly normochromic and normocytic, and teardrop RBCs are not found. There are,
however, about two nucleated red blood cells per 100 white cells. Which of the following is the most
likely diagnosis?
a. Fanconi anemia
Microangiopathic hemolytic anemia
c. Myelophthisic anemia
d.
Autoimmune hemolytic anemia
14. Atypical lymphoid cells (mononucleosis cells) in infectious mononucleosis are:
a. Monocytes
b.
c. Killer T cells
d.
B-lymphocytes
15. A 21-year-old man presents with a 5-day history of malaise, sore throat, and fever. Physical
presence of atypical lymphocytes with abundant cytoplasm. A monospot test is positive. What
histologic change would most likely be seen in a biopsy taken from one of his enlarged lymph nodes?
a. Follicular hyperplasia due to a reactive proliferation of B lymphocytes
b. Interfollicular hyperplasia due to a reactive proliferation of T immunoblasts
d. Paracortical hyperplasia due to a neoplastic proliferation of T immunoblasts
16. A 60-year-old woman presents with a painless cervical lymph node mass that has been progressively
enlarging over the past month. Splenomegaly is noted on abdominal examination. A cervical lymph
node biopsy reveals effacement of the architecture by angulated grooved cells in a nodular pattern.
a. The findings are those of a benign neoplasm of lymphoid cells.
b. The findings are those of the least frequently occurring form of non-Hodgkin lymphoma.
c. The most likely common cytogenetic and molecular change is t(14;18) with increased
expression of the oncogene bcl-2.
carcinoma.
17. A 22-year-old student complains of easy fatigability for 2 months. On physical examination, she has
no hepatosplenomegaly or lymphadenopathy. Mucosal gingival hemorrhages are noted. CBC shows
hemoglobin, 9.5 g/dL; MCV, 94 m3; platelet count, 20,000/mm3; and WBC count, 107,000/mm3.
prominent nucleoli, and these cells contain peroxidase positive granules. A bone marrow biopsy
specimen shows 100% cellularity with few residual normal hematopoietic cells. Which of the
following is the most likely diagnosis?
a. Acute lymphoblastic leukemia
Acute myelogenous leukemia
c. Chronic lymphocytic leukemia
d.
Chronic myelogenous leukemia
hemorrhage. Despite prolonged tamponade, bleeding is persistent. A coagulation defect related to the
liver disease is suspected. Which of the following abnormalities is most consistent with this
possibility?
a. Deficiency of all clotting factors except for vWF
c. Deficiency of factors II, V, VII, and X
d. Deficiency of factors IX, X, XI, and XII
19. In a full facility blood bank, the packed red cells can be kept at 1?6-degree Celsius temperature for
maximum.......?
b.
42 days
c. 6 days
d.
20. Which of the following behaviour of a medical practitioner is inappropriate when communicating the
medical condition to a patient?
a. Explaining the situation in small parts to the patient and attendant.
b. Waiting for the patient to understand about his/her illness
d. Listening to all issues of patient before making a diagnosis and start treatment. Page 3 of 4
Q.2 . 68 years female presented with hypothermia, tachycardia, low blood pressure (90/50 mm Hg). Patient
was diabetic and was having high grade fever for last 6 days and was taking antibiotics for UTI. PBF
a.
What is the diagnosis?
b.
What is pathogenesis of the disease?
What are morphological changes in various stages of disease and complications?
[2+5+5]
Q. 3. Write short notes on:
[5x4]
Compare and contrast necrosis and apoptosis
b.
Multiple myeloma
c.
d.
Fatty liver
Q.4. Explain why:
[3x5]
Reticulocyte count is raised in haemolytic anemia
b.
Red cell life span is shortend in spherocytosis
c.
d.
Delayed healing occurs in chronic infection
e.
Red infarct is seen in lungs
[6x3]
a.
PBF and BM findings in megaloblastic anemia
b.
c.
Leukemoid reaction
Q.6. Write short answer:
[5x3]
a.
Pathogenesis of AIDS
Chemical carcinogenesis
c.
Informed consent in medical practice
-------------------
Q.P. Code: MBN201
M.B.B.S. 2nd Prof.
(New Scheme w.e.f. 2019 admission onwards)
BF/2022/06
--- Content provided by FirstRanker.com ---
Pathology ? AM.M. : 100
Time : 3 Hours(First 30 Min. for MCQs)
Note: 1.
--- Content provided by FirstRanker.com ---
Use OMR Sheet to answer Multiple Choice Questions(MCQs).2.
Attempt all questions. Illustrate your answers with suitable diagrams
3.
NO SUPPLEMENTARY SHEET SHALL BE ALLOWED/PROVIDED
--- Content provided by FirstRanker.com ---
4.The student must write Q.P. Code in the space provided on OMR Sheet and the Title page of
the Answer Book.
Q.1
MCQs (Attempt on OMR sheet)
--- Content provided by FirstRanker.com ---
[1x20]1. A 16-year-old girl undergoes radiologic imaging of her abdomen and is found to have only one kidney.
She had been entirely unaware of this problem. Which of the following terms is most descriptive of
this finding?
a. Agenesis
--- Content provided by FirstRanker.com ---
b.Atrophy
c. Hyperplasia
d.
Hypoplasia
--- Content provided by FirstRanker.com ---
2. A 38-year-old male presents with widespread ecchymoses and bleeding gums. Laboratory examinationof his peripheral blood reveals a normochromic, normocytic anemia, along with a decreased number of
platelets and an increased number of white blood cells. Coagulation studies reveal prolonged
prothrombin and partial thromboplastin time with bone marrow examination revealing blast like cells
with numerous Auer rods. These immature cells make up about 38% of the nucleated cells in the
--- Content provided by FirstRanker.com ---
marrow. The most likely diagnosis for this patient isa. Acute lymphoblastic leukemia
b. Acute monocytic leukemia
c. Acute myelomonocytic leukemia d. Acute promyelocytic leukemia
3. A 40-year M, presented with fever and cough. His TLC is 1,00,000/cu.mm; DLC: Neutrophils- 80%;
--- Content provided by FirstRanker.com ---
Metmylocytes-6%; Myelocytes- 3%. LAP score- 130. What is his diagnosis.a.
CML
b.
AML-M3
--- Content provided by FirstRanker.com ---
c.Leukemoid reaction
d.
MDS
4. A 30-year-old woman presents with a painless nodular swelling on her right ear lobe. She reports that
--- Content provided by FirstRanker.com ---
her ears were pierced 4 months ago. A biopsy was taken and sent for histopathological examination.Histopathology showed dense hyalinised collagen with fibroblasts and myofibroblasts. Which of the
following best explains the pathogenesis of this lesion?
a. Clonal expansion of smooth muscle cells
b. Exuberant formation of granulation tissue
--- Content provided by FirstRanker.com ---
c. Increased turnover of extracellular matrix proteoglycansd. Maturation arrest of collagen assembly
5. A 22-year-old male patient asks for advice regarding seasonal eye itching and runny nose. Recurrent
conjunctivitis in this patient is most likely caused by which of the following mechanisms of disease?
a. Autoimmunity
--- Content provided by FirstRanker.com ---
b.Bacterial infection
c. Chemical toxicity
d.
Hypersensitivity
--- Content provided by FirstRanker.com ---
6. A 35-year-old man presents with the new onset of a "bulge" in his left inguinal area. On surgicalexcision the tissue is sent to pathology lab with label "lipoma of the cord." The pathology resident
examines the tissue and infers that it's not a neoplastic lipoma, but instead is nonneoplastic normal
adipose tissue. Which one of the following features could best differentiate a benign well-
differentiated lipoma from normal adipose tissue?
--- Content provided by FirstRanker.com ---
a. Cellular pleomorphismb.
Clonal proliferation
c. Numerous mitoses
d.
--- Content provided by FirstRanker.com ---
Prominent nucleoliPage 1 of 4
7. A 33-year-old woman discovers a lump in her left breast on self-examination. Her mother and sister
both had breast cancer. Needle aspiration reveals the presence of malignant, ductal epithelial cells.
Genetic screening identifies a mutation in BRCA1. In addition to cell cycle control, BRCA1 protein
--- Content provided by FirstRanker.com ---
promotes which of the following cellular functions?a. Apoptosis
b.
Cell adhesion
c. DNA repair
--- Content provided by FirstRanker.com ---
d.Gene transcription
8. A 58-year-old man with a 3-pack-per day smoking history presents to the emergency department with
shortness of breath and hemoptysis. Portable chest radiography demonstrates a large mass centrally
located within the left lung field. The serum calcium is 13.0 mg/dL (normal 8.5 to 10.2). The
--- Content provided by FirstRanker.com ---
metabolic abnormality described here is likely due to elaboration of which substance?a. Adrenocorticotropic hormone?like substance
b. Antidiuretic hormone
c.
Carcinoembryonic antigen
--- Content provided by FirstRanker.com ---
d. Parathyroid-related hormone9. Few men on years long trip on a ship developed some kind of disease and finally died. Months later, a
rescue team finds the bodies of the men. All have a hyperkeratotic, papular rash; ecchymoses; and
severe gingival swelling with hemorrhages. Which of the following was most likely a contributing
cause of death in these men?
--- Content provided by FirstRanker.com ---
a. Beriberib.
Kwashiorkor
c. Pellagra
d.
--- Content provided by FirstRanker.com ---
Scurvy10. A 36-year-old man dies during cardiac surgery. He had a history of long-standing rheumatic heart
disease with mitral stenosis. At autopsy, the pathologist reports findings consistent with mitral stenosis
and noted the presence of "heart failure cells." This finding results from
a. activation of the coagulation cascade.
--- Content provided by FirstRanker.com ---
b. chronic passive congestion of the lungs.c. hypoxic myocardial injury.
d. myocardial hyperemia.
11. A 32-year-old woman gives birth at 34 weeks' gestation to a markedly hydropic stillborn male infant.
Autopsy findings include hepatosplenomegaly and cardiomegaly, serous effusions in all body cavities,
--- Content provided by FirstRanker.com ---
and generalized hydrops. No congenital anomalies are noted. There is marked extramedullaryhematopoiesis in visceral organs. Which of the following hemoglobins is most likely predominant on
hemoglobin electrophoresis of the fetal RBCs?
a. Hemoglobin A1
b.
--- Content provided by FirstRanker.com ---
Hemoglobin A2c. Hemoglobin Bart's
d.
Hemoglobin E
12. A 6yrs old child belonging to Punjabi family with past history of blood transfusions presented with
--- Content provided by FirstRanker.com ---
hemoglobin 3.5 g/dl, MCV ? 30 fl, MCHC ? 20. Peripheral smear findings of microcytic hypochromicanemia with target cell and reduced osmotic fragility. What is the probable diagnosis of patient?
a. Alpha thalassemia
b.
Beta thalassemia
--- Content provided by FirstRanker.com ---
c. Sickle cell anemiad.
G6PD deficiency
13. A 67-year-old man presents with increasing fatigue and is found to be anemic. Physical examination
reveals a hard 1-cm nodule in the left lobe of the prostate. The prostatic-specific antigen (PSA) level is
--- Content provided by FirstRanker.com ---
found to be elevated. Examination of the peripheral blood reveals an occasional myelocyte. Theerythrocytes are mainly normochromic and normocytic, and teardrop RBCs are not found. There are,
however, about two nucleated red blood cells per 100 white cells. Which of the following is the most
likely diagnosis?
a. Fanconi anemia
--- Content provided by FirstRanker.com ---
b.Microangiopathic hemolytic anemia
c. Myelophthisic anemia
d.
Autoimmune hemolytic anemia
--- Content provided by FirstRanker.com ---
Page 2 of 414. Atypical lymphoid cells (mononucleosis cells) in infectious mononucleosis are:
a. Monocytes
b.
--- Content provided by FirstRanker.com ---
CD8 + T lymphocytesc. Killer T cells
d.
B-lymphocytes
15. A 21-year-old man presents with a 5-day history of malaise, sore throat, and fever. Physical
--- Content provided by FirstRanker.com ---
examination finds bilateral cervical lymphadenopathy. Examination of the peripheral blood reveals thepresence of atypical lymphocytes with abundant cytoplasm. A monospot test is positive. What
histologic change would most likely be seen in a biopsy taken from one of his enlarged lymph nodes?
a. Follicular hyperplasia due to a reactive proliferation of B lymphocytes
b. Interfollicular hyperplasia due to a reactive proliferation of T immunoblasts
--- Content provided by FirstRanker.com ---
c. Nodular hyperplasia due to a neoplastic proliferation of monocytoid B cellsd. Paracortical hyperplasia due to a neoplastic proliferation of T immunoblasts
16. A 60-year-old woman presents with a painless cervical lymph node mass that has been progressively
enlarging over the past month. Splenomegaly is noted on abdominal examination. A cervical lymph
node biopsy reveals effacement of the architecture by angulated grooved cells in a nodular pattern.
--- Content provided by FirstRanker.com ---
Which of the following statements about this disorder is correct?a. The findings are those of a benign neoplasm of lymphoid cells.
b. The findings are those of the least frequently occurring form of non-Hodgkin lymphoma.
c. The most likely common cytogenetic and molecular change is t(14;18) with increased
expression of the oncogene bcl-2.
--- Content provided by FirstRanker.com ---
d. Special stains are required for the diagnosis because the description is that of an anaplasticcarcinoma.
17. A 22-year-old student complains of easy fatigability for 2 months. On physical examination, she has
no hepatosplenomegaly or lymphadenopathy. Mucosal gingival hemorrhages are noted. CBC shows
hemoglobin, 9.5 g/dL; MCV, 94 m3; platelet count, 20,000/mm3; and WBC count, 107,000/mm3.
--- Content provided by FirstRanker.com ---
Her peripheral blood smear showed large atypical cells resembling blasts with fine chromatin andprominent nucleoli, and these cells contain peroxidase positive granules. A bone marrow biopsy
specimen shows 100% cellularity with few residual normal hematopoietic cells. Which of the
following is the most likely diagnosis?
a. Acute lymphoblastic leukemia
--- Content provided by FirstRanker.com ---
b.Acute myelogenous leukemia
c. Chronic lymphocytic leukemia
d.
Chronic myelogenous leukemia
--- Content provided by FirstRanker.com ---
18. A 60-year-old chronic alcoholic with known alcoholic cirrhosis presents with upper gastrointestinalhemorrhage. Despite prolonged tamponade, bleeding is persistent. A coagulation defect related to the
liver disease is suspected. Which of the following abnormalities is most consistent with this
possibility?
a. Deficiency of all clotting factors except for vWF
--- Content provided by FirstRanker.com ---
b. Deficiency of factors II, VII, IX, and Xc. Deficiency of factors II, V, VII, and X
d. Deficiency of factors IX, X, XI, and XII
19. In a full facility blood bank, the packed red cells can be kept at 1?6-degree Celsius temperature for
maximum.......?
--- Content provided by FirstRanker.com ---
a. 10 daysb.
42 days
c. 6 days
d.
--- Content provided by FirstRanker.com ---
180 days20. Which of the following behaviour of a medical practitioner is inappropriate when communicating the
medical condition to a patient?
a. Explaining the situation in small parts to the patient and attendant.
b. Waiting for the patient to understand about his/her illness
--- Content provided by FirstRanker.com ---
c. Not telling the patient about the poor outcome of the illness.d. Listening to all issues of patient before making a diagnosis and start treatment. Page 3 of 4
Q.2 . 68 years female presented with hypothermia, tachycardia, low blood pressure (90/50 mm Hg). Patient
was diabetic and was having high grade fever for last 6 days and was taking antibiotics for UTI. PBF
--- Content provided by FirstRanker.com ---
showed leukocytosis (TLC-18000/cmm)a.
What is the diagnosis?
b.
What is pathogenesis of the disease?
--- Content provided by FirstRanker.com ---
c.What are morphological changes in various stages of disease and complications?
[2+5+5]
Q. 3. Write short notes on:
[5x4]
--- Content provided by FirstRanker.com ---
a.Compare and contrast necrosis and apoptosis
b.
Multiple myeloma
c.
--- Content provided by FirstRanker.com ---
Chronic granulomatous inflammationd.
Fatty liver
Q.4. Explain why:
[3x5]
--- Content provided by FirstRanker.com ---
a.Reticulocyte count is raised in haemolytic anemia
b.
Red cell life span is shortend in spherocytosis
c.
--- Content provided by FirstRanker.com ---
Reed-Sternberg cell is characteristic and diagnostic in Hodgkin lymphomad.
Delayed healing occurs in chronic infection
e.
Red infarct is seen in lungs
--- Content provided by FirstRanker.com ---
Q.5. Write short notes on(applied aspects):[6x3]
a.
PBF and BM findings in megaloblastic anemia
b.
--- Content provided by FirstRanker.com ---
How will you investigate a patient with purpuric spots on the bodyc.
Leukemoid reaction
Q.6. Write short answer:
--- Content provided by FirstRanker.com ---
--- Content provided by FirstRanker.com ---
[5x3]
a.
Pathogenesis of AIDS
--- Content provided by FirstRanker.com ---
b.Chemical carcinogenesis
c.
Informed consent in medical practice
-------------------
--- Content provided by FirstRanker.com ---
Page 4 of 4