Download BFUHS MBBS 2nd Year MBN205 Microbiology A Dec 2022 mcq Question Paper

Total No. = 03 pages
Q.P. Code: MBN205
M.B.B.S. 2nd Prof.
(New Scheme w.e.f. 2019 admission onwards)
BF/2022/06

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Microbiology ? A
M.M. : 100
Time : 3 Hours(First 30 Min. for MCQs)
Note: 1.
Use OMR Sheet to answer Multiple Choice Questions(MCQs).

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2.
Attempt all questions. Illustrate your answers with suitable diagrams
3.
NO SUPPLEMENTARY SHEET SHALL BE ALLOWED/PROVIDED
4.

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The student must write Q.P. Code in the space provided on OMR Sheet and the Title page of the
Answer Book.
Q.1
MCQs (Attempt on OMR sheet)
[1x20]

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1.
The father of antiseptic surgery is
a.
LouisPasteur
b.

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Robert Koch
c.
Julius Petri
d.
Joseph Lister

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2.
An eighty year old man presented with a 2month history of low grade fever and facial swelling. He is a
known diabetic and has long standing hypertension. Echocardiography has revealed vegetations on the
implanted Valve. The likely diagnosis is
a.

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Infective endocarditis
b.
Mitral stenosis
c.
Septal defect

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d.
Pericarditis
3.
A 15-year-old girl develops severe watery diarrhea. The stool looks like "rice water." It is
voluminous--more than 1 L in the last 90 minutes. She has no fever and seems otherwise normal

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except for the effects of loss of fluid and electrolytes. Which of the following is the most likely cause
of her illness?
a.
Staphylococcal enterotoxin
b.

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Cholera Toxin -A toxin with A and B subunits
c.
Shigella dysenteriae type 1 that produces Shiga toxin
d.
Enterotoxigenic E coli that produces heat-labile and heatstable toxins

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4.
One of the widely used method of sterilization method in a hospital is autoclaving. The holding time in
autoclave for sterilization at121?C(15psi) is
a.
5 minutes

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b.
10 minutes
c.
15 minutes
d.

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20 minute
5.
Disinfection refers to the process that destroys or removes most pathogenic organism. Which of the
following are capable of killing bacterial spores?
a.

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Antiseptics
d.
High level disinfectants
c.
Intermediate level disinfectants

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d.
Low level disinfectants
6.
Antimicrobial therapy can decrease the amount of susceptible bowel flora and allow proliferation of
relatively resistant colonic bacteria. Which one of the following species can proliferate and produce a

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toxin that causes diarrhea?
a.
Enterococcus species
b.
Staphylococcus epidermidis

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c.
Pseudomonas aeruginosa
d.
Clostridium difficile
7.

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Solid media containing inhibitory substances that inhibit normal flora in the specimen and allow
pathogens to grow are called:
a.
Enriched media
b.

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Selective media
c.
Differential media
d.
Basal media

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8.
Fifty five year old man was on renal dialysis for the last five years. Recently, he received a renal
transplant from his brother.All functions remained normal for two weeks after the transplantation. But
after that, tenderness appeared at the operative site, creatinine levels rose and the renal biopsy revealed
increased lymphocytic infiltrates in the renal cortical region. What type of clinical graft rejection has

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occurred in this case?
a.
acute rejection
b.
Hyperacute rejection

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c.
Chronic rejection
d.
None of the above

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9. Which of the following contains structures composed of N-acetylmuramic acid and N- acetylglucosamine?
a.
Mycoplasmas
b.

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Amoeba
c.
Escherchia coli
d.
Spheroplast

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10.
A diarrhoeal outbreak occurred in a military camp in Rishikesh,India.No bacterial pathogens were
isolated.The stool specimens were inoculated into cell cultures.The pattern of cytopathogenic
effect(CPE) observed on the Hela cell line was of cells:becoming swollen,rounded,refractile and
getting clustered together as a`bunch of grapes'. The likely diagnosis the the case is

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a.
Adenoviral infection
b.
CMV infection
c.

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Poliomyelitis
d.
Norwalk infection
11.
As per Universal immunization program( UIP), the new born is administered vaccines for prophlaxis

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at birth. Which of the following live attenuated vaccine is given intradermally?
a.
Hepatitis B
b.
BCG

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c.
OPV
d.
DPT
12.

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A patient presented with the painless indurated ulcer with thick exudates on the genital area. The
doctor made the diagnosis of Syphilis and sent you the swab sample for observation. Which of the
following microscope would you like to use for making the diagnosis?
a.
Light microscope

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b.
Dark ground microscope
c.
Electron microscope
d.

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Compound Light microscope
13.
A forty five year male presented with passing of 4-6 motions per day.It was copious in amount and red
tinged. A microscopic examination of the faeces revealed many motile trophozoites about 15?m in
size and few cysts (approximately 10?m). The case was able to perform his daily duties. The likely

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diagnosis is
a.
Amoebic Dysentry
b.
Balantidium coli dysentery

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c.
Bacillary dysentery
d.
Cryptoridium infection
14. Type1 hypersensitivity is mediated by

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a.
IgE
b.
IgG
c.

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IgM
d.
IgD
15.
An eight year old girl,presented to a medical practitioner with sore throat and fever. The key non-

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suppurative complication of S.pyogenes infection is
a.
Rheumatic heart disease
b.
Endocarditis

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c.
Hepatitis
d.
Retinitis
16.

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A thirty year old businessman with fever and abnormal behavior, after his return to Paris from a 10 day
business trip to Jaipur. He gave history of eating at local eatery a week back and subsequently
developing gastrointestinal disturbance. His examination revealed a mildly enlarged spleen,
palpable(2cm below left costal margin) and blood examination revealed leucopenia. On blood culture,
no organism could be isolated. Widal test revealed significantly raised specific antibodies against

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S.Typhi antigens. The likely clinical diagnosis of this case is
a.
Enteric fever
b.
Leptospirosis

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c.
Brucellosis
d.
Listeriosis
17.

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A forty five year old male presented to medical emergency with generalized convulsions and high
fever. A thick smear examination of blood for malarial parasite revealed some RBCs with multiple
rings were detected in thick smear examination. The likely diagnosis is
a.
Acute falciparum malaria

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b.
P. vivax malaria
c.
P. ovale malaria
d.

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P. malariae infection
18.
A 16 month male, was admitted to the paediatric emergency with presentation of mild fever, severe
diarrhoea and vomiting. Physical examination revealed severe dehydration. Microscopic stool
examination revealed absence of leucocytes, ova, cyst or any parasites. The commonest virus that can

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present a picture like the one in this case can be
a.
Rotavirus
b.
Coronaviruses(enteric)

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c.
Norwalk
d.
Norovirus

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19.
An army Jawan, presented to a tertiary care center with low grade fever, weakness and generalized

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lymphadenopathy of 5weeks duration. Detailed history revealed visits to hilly region of Srinagar,
where he consumed raw goat milk. Routine investigations; as Widal test, Rheumatoid factor, Paul
Bunnel test, and whole body CT scan did not yield any clue. Blood culture revealed gram negative
bacilli, after 6 days of incubation. Liver biopsy showed non-caseating granulomas. The likely
diagnosis is

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a.
Brucellosis
b.
Tularensis
c.

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Salmonellosis
d.
Epidemic Typhus
20.
A six year old male presented to the paediatric OPD with picture of significant weight loss. The stool

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was greasy and foul smelling. The mother on further questioning informed that the stool used to float
in the Western toilet. Microscopic examination revealed pear shaped trophozoites(14?m in length).The
likely diagnosis is
a.
Giardia infection

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b.
Amebic infection
c.
Cryptosporidial infection
d.

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Free living amebic infection
Q.2. A 32 years male truck driver reported to OPD with creamy white patches in oral cavity extensively
distributed on tongue and mucosa for two weeks. Physcial examination revealed generalized
lymphadenopathy. There is history of frequent sexual exposure with multiple sex partners. Gram
staining of scrapings from patches revealed numerous gram positive oval budding yeast cells.

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Provisional clinical diagnosis is suspected as HIV infection.
[4+4+2+2]
a.
Enumerate specific tests and nonspecific immunological tests for laboratory diagnosis of HIV.
b.

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Enumerate the NACO strategies including plan/algorithms for HIV testing in developing/poor
countries.
c.
Draw a labeled diagram of HIV
d.

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List important opportunistic infections in HIV infected patient
Q.3. Write short notes on:-
[5x4]
a.
Differences between primary immune response and secondary immune response

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b.
Secretry immunity
c.
Bacterial nucleus
d.

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Principle of hot air oven and list four articles that are routinely sterilized in it
Q.4. Explain in short:-
[3x5]
a.
Agglutination reaction

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b.
Type-III hypersensitivity reaction
c.
Hepatitis A
d.

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Amoebic liver abscess
e.
Peripheral smear examination for malarial parasite
Q.5. Short answers (applied aspects):-
[6x3]

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a.
Diarrheagenic Escherichia coli
b.
Bacterial growth curve
c.

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Describe pathogenesis of dengue hemorrhage fever. How will you diagnose dengue
hemorrhage fever in the laboratory?
Q.6. Write in brief about: -
[5x3]
a.

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Father of bacteriology
b.
RT-PCR for Covid-19 testing
c.
Your personal attributes and attitude while dealing with the patients reporting to microbiology

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laboratory
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