Jabalpur
MBBS Second Professional Examination August-
2024
Subject- Pharmacology
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Paper- II (new scheme)Time: 3 Hours
Max. Marks: 100
Instructions:
a) All questions are compulsory
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b) Draw diagrams wherever necessaryc) Answers of Questions and Sub-questions must be
written strictly according to serial order of question paper.
d) MCQ has to be answered in theory answer book
e) Please write MCQ answer neatly and in serial order
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with black or blue pen in brackets; for example: - 1. (a) 2.(c)
f) MCQ has to be answered only once, any kind of
repetition or cutting or erasing or whitener will be
considered as malpractice, such answers will not be
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counted in marks and action will be taken according toUFM rules of university.
g) Subjective answer should be answered in up to 30
words per marks. For example, if a question having 2
marks should answered in up to 60 marks.
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Q1. Total MCQs: 10 ? 10 x 1 = 101. Action of flumazenil on benzodiazepine receptor is:
(a) Agonist
(b) Partial agonist
(c) Inverse agonist
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(d) Antagonist2. Which of the following drug should not be given along
with levodopa:
(a) Carbidopa
(b) MAO inhibitors
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(c) Vitamin B complex(d) Benserazide
3. Which of the following statement about phenytoin is
true?
(a) It follows zero order kinetics
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(b) It is not teratogenic(c) It is excreted unchanged in urine
(d) It does not induce microsomal enzymes
4. Erythromycin is given in intestinal hypomotility
because:
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(a) It increases bacterial count(b) It decreases bacterial count
(c) It binds to adenylyl cyclase
(d) It binds to motilin receptors
5. Which of the following drug does not induce
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extrapyramidal side effects?(a) Metoclopramide
(b) Domperidone
(c) Haloperidol
(d) Chlorpromazine
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6. Uricosuric drug among these is:(a) Probenecid
(b) Colchicine
(c) Allopurinol
(d) All of these
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7. Drug causing Fanconi's syndrome is:(a) Tetracycline
(b) Ciprofloxacin
(c) Gentamicin
(d) Clarithromycin
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8. Which is the common side effect of aminoglycosideantibiotics:
(a) Nausea
(b) Abdominal pain
(c) Nephrotoxicity
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(d) Hepatotoxicity9. Which of the following is the most common
paradoxical side effect of Indomethacin:
(a) Hypersensitivity
(b) Peptic Ulcer
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(c) Frontal headache(d) Nephropathy
10. Which anesthetic agent is contraindicated in epilepsy?
(a) Xenon
(b) Enflurane
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(c) Halothane(d) Ether
Q2. Long Answer Questions ? 2 x 20 = 40
a. A 45-year male diagnosed as a case of schizophrenia
based on disturbed thinking process, inappropriate talking
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and behavior, restlessness, bursts of temper, anxiety, poorself-care, disturbed sleep, delusional beliefs, and
occasional auditory hallucinations. (5+5+5+5)
I. Classify the drugs used for the treatment of above
condition and enumerate the longer acting injectables
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(LAI) for the same.II. Write down the mechanism of action and uses of
Haloperidol.
III. Adverse drug reactions of Haloperidol and its
management.
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IV. Compare between Haloperidol and Olanzapine.b. A 45-year male office executive with sedentary
lifestyle was diagnosed to have developed type 2 diabetes
mellitus. His fasting and post-meal blood glucose was 150
mg/dl and 240 mg/dl respectively, HbA1C was 7.8%, BP
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was 150/92 mm Hg. He was advised suitable diet,exercise, and other lifestyle modifications. (5+5+5+5)
I. Classify Oral Antidiabetic agents and Enumerate the
Insulin analogues.
II. Mechanism of action of Sulfonylureas.
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III. Mechanism of action and Advantages of Metformin.IV. Management of Diabetic coma.
Q3. Brief Answer Questions ? 6 x 05 = 30
a. Differentiate between Benzodiazepine and Barbiturate.
b. Discuss the therapeutic uses of Corticosteroids.
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c. Write a short note on Pre-anesthetic medications.d. Mechanism and Adverse effects of Sulphonamides
antibiotics.
e. Discuss the adverse effects of first line Antitubercular
drugs.
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f. Management of severe complicated falciparum malaria.Q4. Short Answer Questions ? 10 x 2 = 20
a. Enumerate drugs used for treatment of MRSA
(Methicillin Resistant Staphylococcus Aureus)
b. Write in brief about mechanism of Colchicine in Gout.
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c. Name any four atypical antidepressants.d. Explain, Why Ethyl alcohol is used in methyl alcohol
poisoning.
e. Explain why, Aspirin is contraindicated in children
with viral fever.
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f. Enlist the important adverse effects of Amphotericin-B.g. Name any four biological agents used in Rheumatoid
Arthritis.
h. Explain, why Cilastatin is combined with imipenem.
i. Mention disadvantage of using selective COX-2
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inhibitor.j. Write two Second generation antihistamines and their
two uses.
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