Q.P. CODE:
DR NTR UNIVERSITY OF HEALTH
SCIENCES :: AP :: VIJAYAWADA
B.Sc(Nursing) DEGREE EXAMINATIONS ? ,
FIRST YEAR EXAMINATION ? 4 YDC
(NEW SCHEME)
Time: 3:00 Hours
Max. Marks: 75
Instructions:
b) Draw diagrams wherever necessary
c) Answers of Questions and Sub-questions must be
written strictly according to serial order of question
paper.
e) Please write MCQ answer neatly and in serial order
with black or blue pen in brackets; for example: - 1.
(a) 2. (c)
f) MCQ has to be answered only once, any kind of
considered as malpractice, such answers will not be
counted in marks and action will be taken according to
UFM rules of university.
g) Subjective answer should be answered in up to 30
marks should answered in up to 60 marks.
Q1. Total MCQs: 16
1) Which of the following is a PHARMACODYNAMIC
process?
(b) Drug metabolites are removed in the urine
(c) Movement of drug from the gut into general
circulation
(d) The drug causes receptor stimulation and response
this adrenoceptor agonist produced bronchodilation?
(a) Increased cyclic AMP
(b) Decreased cyclic GMP
(c) Decreased IP3
3) Topical administration to the eye of which of the
following agents is likely to induce mydriasis and
cycloplegia?
(a) Beta blocker
(c) Alpha agonist
(d) Muscarinic blocker
4) A patient on neostigmine therapy for Myasthenia
gravis complains of progressive fatigue and diplopia who
dose edrophonium elicits a significant improvement in her
muscle strength. Which of the following is the best next
step in the management of this patient?
(a) Increase neostigmine dosage
(c) Stop neostigmine temporarily
(d) Add low dose propranolol
5) Which of the following is the drug of choice for
essential hypertension with benign prostatic hyperplasia
(a) Propranolol
(b) Prazosin
(c) Neostigmine
(d) Dopamine
use of this beta blocker?
(a) Bronchodilation, hypotension, and hyperglycemia
(b) Bronchoconstriction, hyperglycemia, and
hyperlipidemia
(d) Migraine headaches, hypertension, and tocolysis
(uterine relaxation)
7) Which of the following antihistamines would be the
MOST appropriate treatment for a 32-year-old airline
and complains of postnasal drainage, coughing, and throat
irritation?
(a) Diphenhydramine
(b) Fexofenadine
(d) Chlorpheniramine
8) A diuretic which acts in the thick ascending loop of the
nephron would cause:
(a) Hyporeninemia, hyperkalemia, and
(b) Hypercalcemia, hyperlipidemia, hypokalemia, and
hyperuricemia
(c) Hyperglycemia, hypokalemia, and metabolic
acidosis
vasodilation in renal vasculature
9) A 49-year-old female with post-surgical deep-vein
thrombosis (DVT) is given a bolus of heparin, and a
heparin drip is also started. Twenty-five minutes later, she
heparin is stopped, but the bleeding continues. The
attending physician decides to give a counteragent to the
adverse effect of heparin. What drug was given?
(a) Factor XII
(c) Protamine sulfate
(d) Vitamin K
10) A class of anti-anginal medications with multiple
mechanisms of action that include: decreased preload,
doses), and increased myocardial oxygen delivery by
dilating large epicardial arteries.
(a) Beta blocker
(b) Calcium channel blocker
(c) Nitrate
(d) Anti-platelet drug
11) In a 32-year-old woman with a long history of
bronchial asthma, the use of mometasone aerosol for
treatment is likely to produce which of the following?
(b) Essential hypertension
(c) Truncal obesity
(d) Voice hoarseness
12) A patient undergoing cancer chemotherapy is
the 5HT3 receptor. Which drug was used in this case?
(a) Buspirone
(b) Cyproheptadine
(c) Ondansetron
13) A 54-year-old man is being treated for peptic ulcer
disease and subsequently develops gynecomastia. Which
of the following drugs is he most likely taking?
(a) Cimetidine
(c) Omeprazole
(d) Ranitidine
14) A new drug has been developed with the following
characteristics: when 100 mg of the drug is injected, 95
and 85 mg remains after 6 hours. This drug shows
elimination properties similar to which of the following
drugs in high doses?
(a) Aspirin
(b) Clonidine
(c) Morphine
(d) Propranolol
15) Neostigmine will effectively antagonize skeletal
muscle relaxation produced by:
(b) Succinylcholine
(c) Diazepam
(d) Baclofen
16) A 42-year-old male with an acute MI is given
streptokinase?
(a) Inhibition of platelet thromboxane production
(b) Antagonism of ADP receptor
(c) Glycoprotein IIb/Illa antagonist
Q2. Long Answer Questions
a. Enumerate 4 commonly prescribed Angiotensin
Converting Enzyme Inhibitors (ACEIs). Write 4 uses of
ACEIs and explain the underlying pharmacological
Enumerate 4 adverse effects of ACEIs.
b. Classify drugs used in Peptic Ulcer Disease. Write the
mechanism of action, uses, and adverse effects of Proton
Pump Inhibitors (PPIs). Mention one drug regimen for the
Q3. Brief Answer Questions
a. Enumerate Low Molecular Weight Heparins
(LMWHs). Write advantages of LMWHs in comparison to
Unfractionated Heparin.
order kinetics of drug elimination.
c. Write the mechanism of action, uses, adverse effects,
and contraindications of Osmotic diuretics.
d. Enumerate uses of adrenaline and discuss the
Q4. Short Answer Questions
a. Mention 4 factors that can alter the apparent volume of
distribution of a drug.
b. Explain the pharmacological basis of the combination
combinations available in the market.
c. Explain the pharmacological basis of the combination
of Hydrochlorothiazide and Triamterene.
d. Enumerate 2 drugs each for acute and long-term
e. Enumerate 2 drugs belonging to two different groups
used in the treatment of hypertensive emergency.
f. Explain the pharmacological basis of the combination
of Calcium and Magnesium salts in most antacid
g. Write 2 examples of competitive antagonists.
h. Enumerate 2 drugs used in the treatment of productive
cough.
i. Name one important drug interaction of sildenafil
j. Name a drug for Paroxysmal Supraventricular
Tachycardia.
***
DR NTR UNIVERSITY OF HEALTH
SCIENCES :: AP :: VIJAYAWADA
B.Sc(Nursing) DEGREE EXAMINATIONS ? ,
FIRST YEAR EXAMINATION ? 4 YDC
--- Content provided by FirstRanker.com ---
PHARMACOLOGY(NEW SCHEME)
Time: 3:00 Hours
Max. Marks: 75
Instructions:
--- Content provided by FirstRanker.com ---
a) All questions are compulsoryb) Draw diagrams wherever necessary
c) Answers of Questions and Sub-questions must be
written strictly according to serial order of question
paper.
--- Content provided by FirstRanker.com ---
d) MCQ has to be answered in theory answer booke) Please write MCQ answer neatly and in serial order
with black or blue pen in brackets; for example: - 1.
(a) 2. (c)
f) MCQ has to be answered only once, any kind of
--- Content provided by FirstRanker.com ---
repetition or cutting or erasing or whitener will beconsidered as malpractice, such answers will not be
counted in marks and action will be taken according to
UFM rules of university.
g) Subjective answer should be answered in up to 30
--- Content provided by FirstRanker.com ---
words per marks. For example, if a question having 2marks should answered in up to 60 marks.
Q1. Total MCQs: 16
1) Which of the following is a PHARMACODYNAMIC
process?
--- Content provided by FirstRanker.com ---
(a) Biochemical alteration of the drug by liver enzymes(b) Drug metabolites are removed in the urine
(c) Movement of drug from the gut into general
circulation
(d) The drug causes receptor stimulation and response
--- Content provided by FirstRanker.com ---
2) Which out of the following is the mechanism by whichthis adrenoceptor agonist produced bronchodilation?
(a) Increased cyclic AMP
(b) Decreased cyclic GMP
(c) Decreased IP3
--- Content provided by FirstRanker.com ---
(d) Calcium influx3) Topical administration to the eye of which of the
following agents is likely to induce mydriasis and
cycloplegia?
(a) Beta blocker
--- Content provided by FirstRanker.com ---
(b) Alpha blocker(c) Alpha agonist
(d) Muscarinic blocker
4) A patient on neostigmine therapy for Myasthenia
gravis complains of progressive fatigue and diplopia who
--- Content provided by FirstRanker.com ---
was otherwise well controlled previously. Infusion of lowdose edrophonium elicits a significant improvement in her
muscle strength. Which of the following is the best next
step in the management of this patient?
(a) Increase neostigmine dosage
--- Content provided by FirstRanker.com ---
(b) Administer pralidoxime(c) Stop neostigmine temporarily
(d) Add low dose propranolol
5) Which of the following is the drug of choice for
essential hypertension with benign prostatic hyperplasia
--- Content provided by FirstRanker.com ---
(BPH)?(a) Propranolol
(b) Prazosin
(c) Neostigmine
(d) Dopamine
--- Content provided by FirstRanker.com ---
6) Which of the following is most likely to occur with theuse of this beta blocker?
(a) Bronchodilation, hypotension, and hyperglycemia
(b) Bronchoconstriction, hyperglycemia, and
hyperlipidemia
--- Content provided by FirstRanker.com ---
(c) Urination, diarrhea, and mydriasis(d) Migraine headaches, hypertension, and tocolysis
(uterine relaxation)
7) Which of the following antihistamines would be the
MOST appropriate treatment for a 32-year-old airline
--- Content provided by FirstRanker.com ---
pilot who has a long history of seasonal allergic rhinitisand complains of postnasal drainage, coughing, and throat
irritation?
(a) Diphenhydramine
(b) Fexofenadine
--- Content provided by FirstRanker.com ---
(c) Promethazine(d) Chlorpheniramine
8) A diuretic which acts in the thick ascending loop of the
nephron would cause:
(a) Hyporeninemia, hyperkalemia, and
--- Content provided by FirstRanker.com ---
hypermagnesemia(b) Hypercalcemia, hyperlipidemia, hypokalemia, and
hyperuricemia
(c) Hyperglycemia, hypokalemia, and metabolic
acidosis
--- Content provided by FirstRanker.com ---
(d) Hypokalemia, hypomagnesemia, and preferentialvasodilation in renal vasculature
9) A 49-year-old female with post-surgical deep-vein
thrombosis (DVT) is given a bolus of heparin, and a
heparin drip is also started. Twenty-five minutes later, she
--- Content provided by FirstRanker.com ---
starts bleeding profusely from the intravenous site. Theheparin is stopped, but the bleeding continues. The
attending physician decides to give a counteragent to the
adverse effect of heparin. What drug was given?
(a) Factor XII
--- Content provided by FirstRanker.com ---
(b) Aspirin(c) Protamine sulfate
(d) Vitamin K
10) A class of anti-anginal medications with multiple
mechanisms of action that include: decreased preload,
--- Content provided by FirstRanker.com ---
decreased oxygen demand, decreased afterload (at highdoses), and increased myocardial oxygen delivery by
dilating large epicardial arteries.
(a) Beta blocker
(b) Calcium channel blocker
--- Content provided by FirstRanker.com ---
(c) Nitrate
(d) Anti-platelet drug
11) In a 32-year-old woman with a long history of
bronchial asthma, the use of mometasone aerosol for
treatment is likely to produce which of the following?
--- Content provided by FirstRanker.com ---
(a) Diabetes mellitus(b) Essential hypertension
(c) Truncal obesity
(d) Voice hoarseness
12) A patient undergoing cancer chemotherapy is
--- Content provided by FirstRanker.com ---
administered an antiemetic agent that is an antagonist atthe 5HT3 receptor. Which drug was used in this case?
(a) Buspirone
(b) Cyproheptadine
(c) Ondansetron
--- Content provided by FirstRanker.com ---
(d) Sumatriptan13) A 54-year-old man is being treated for peptic ulcer
disease and subsequently develops gynecomastia. Which
of the following drugs is he most likely taking?
(a) Cimetidine
--- Content provided by FirstRanker.com ---
(b) Misoprostol(c) Omeprazole
(d) Ranitidine
14) A new drug has been developed with the following
characteristics: when 100 mg of the drug is injected, 95
--- Content provided by FirstRanker.com ---
mg remains after 2 hours, 90 mg remains after 4 hours,and 85 mg remains after 6 hours. This drug shows
elimination properties similar to which of the following
drugs in high doses?
(a) Aspirin
--- Content provided by FirstRanker.com ---
(b) Clonidine
(c) Morphine
(d) Propranolol
15) Neostigmine will effectively antagonize skeletal
muscle relaxation produced by:
--- Content provided by FirstRanker.com ---
(a) Pancuronium(b) Succinylcholine
(c) Diazepam
(d) Baclofen
16) A 42-year-old male with an acute MI is given
--- Content provided by FirstRanker.com ---
streptokinase. What is the mechanism of action ofstreptokinase?
(a) Inhibition of platelet thromboxane production
(b) Antagonism of ADP receptor
(c) Glycoprotein IIb/Illa antagonist
--- Content provided by FirstRanker.com ---
(d) Activation of plasminogen to plasminQ2. Long Answer Questions
a. Enumerate 4 commonly prescribed Angiotensin
Converting Enzyme Inhibitors (ACEIs). Write 4 uses of
ACEIs and explain the underlying pharmacological
--- Content provided by FirstRanker.com ---
mechanism of therapeutic benefits for each of those uses.Enumerate 4 adverse effects of ACEIs.
b. Classify drugs used in Peptic Ulcer Disease. Write the
mechanism of action, uses, and adverse effects of Proton
Pump Inhibitors (PPIs). Mention one drug regimen for the
--- Content provided by FirstRanker.com ---
treatment of Helicobacter pylori infection.Q3. Brief Answer Questions
a. Enumerate Low Molecular Weight Heparins
(LMWHs). Write advantages of LMWHs in comparison to
Unfractionated Heparin.
--- Content provided by FirstRanker.com ---
b. Compare and contrast between Zero-order and First-order kinetics of drug elimination.
c. Write the mechanism of action, uses, adverse effects,
and contraindications of Osmotic diuretics.
d. Enumerate uses of adrenaline and discuss the
--- Content provided by FirstRanker.com ---
management of anaphylactic shock.Q4. Short Answer Questions
a. Mention 4 factors that can alter the apparent volume of
distribution of a drug.
b. Explain the pharmacological basis of the combination
--- Content provided by FirstRanker.com ---
of adrenaline and lignocaine in most local anestheticcombinations available in the market.
c. Explain the pharmacological basis of the combination
of Hydrochlorothiazide and Triamterene.
d. Enumerate 2 drugs each for acute and long-term
--- Content provided by FirstRanker.com ---
treatment of Migraine.e. Enumerate 2 drugs belonging to two different groups
used in the treatment of hypertensive emergency.
f. Explain the pharmacological basis of the combination
of Calcium and Magnesium salts in most antacid
--- Content provided by FirstRanker.com ---
preparations.g. Write 2 examples of competitive antagonists.
h. Enumerate 2 drugs used in the treatment of productive
cough.
i. Name one important drug interaction of sildenafil
--- Content provided by FirstRanker.com ---
citrate.j. Name a drug for Paroxysmal Supraventricular
Tachycardia.
***
--- Content provided by FirstRanker.com ---