Download MPMSU MBBS 1st Year Biochemistry Paper I Apr 2022 Question Paper

Madhya Pradesh Medical Science University,
Jabalpur
MBBS First Professional Examination April-2022
Subject- Biochemistry
Paper-I

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Maximum Marks :100
Time: 3:00 Hours
Instructions:
a) All questions are compulsory
b) Draw diagrams wherever necessary

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c) Answers of Questions and Sub-questions must be
written strictly according to serial order of question paper.
d) MCQ has to be answered in theory answer book
e) Please write MCQ answer neatly and in serial order
with black or blue pen in brackets; for example: - 1. (a) 2.

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(c)
f) MCQ has to be answered only once, any kind of
repetition or cutting or erasing or whitener will be
considered as malpractice, such answers will not be
counted in marks and action will be taken according to

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UFM rules of university.
Q1. Total MCQs: 20 20 x 1 = 20
1. Which of the following is not essential fatty acid
(a) oleic acid (b) linoleic acid (c) arachidonic acid (d)
linolenic acid

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2. An amino acid required for porphyrin synthesis is

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(a) proline (b) glycine (c) serine (d) histidine
3. The main source of reducing equivalents NADPH for
lipogenesis is
(a) pentose phosphate pathway (b) citric acid cycle (c)

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glycolysis (d) glycogenolysis
4. The hormones that bind to cell surface receptor and
requires the second messenger action is
(a) thyroxine (b) estrogen (c) FSH (d) glucocorticoids
5. Uncoupling agent of oxidative phosphorylation is

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(a) fructose 1,6 bisphosphate (b) 2,4 dinitrophenol (c)
NADP (d) urea
6. Acute pancreatitis may be diagnosed by the
estimation of following enzyme
(a) alanine transaminase (b) acid phosphatase (c)

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amylase (d) alkaline phosphatase
7. Which organelle is referred to as the 'incinerator' of
the cell containing hydrolytic enzymes
(a) lysosome (b) ribosome (c) peroxisome (d) golgi
apparatus

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8. Phospholipid acting as lung surfactant
(a) phosphatidyl inositol (b) cephalin (c) dipalmitoyl
lecithin (d) sphingomyelin
9. Pellagra occurs due to deficiency of vitamin
(a) B1 (b) B2 (c) B3 (d) B5

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10. High Km means enzyme's affinity for
(a) inhibitor is high (b) substrate is high (c) inhibitor is
low (d) substrate is low
11. Von Gierke's disease occurs due to deficiency of the
following enzyme

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(a) muscle glycogen phosphorylase (b) glucose-6-
phosphatase (c) debranching enzyme (d) glucose-6-
phosphate dehydrogenase
12. Which of the following complexes is inhibited by
cyanide

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(a) complex I (b) complex II (c) complex III (d) complex
IV
13. Which of the following mucopolysaccharide acts as
a lubricant in joints
(a) chondroitin sulfate (b) keratan sulfate (c) dermatan

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sulfate (d) hyaluronic acid
14. Which of the following is a semi essential amino
acid
(a) lysine (b) arginine (c) tyrosine (d) tryptophan
15. Normal range of serum cholesterol is

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(a) 100-150 mg/dL (b) 150-200 mg/dL (c) 200-250
mg/dL (d) 250-300 mg/dL
16. Wilson's disease is due to excess of which mineral
(a) cobalt (b) iodine (c) copper (d) fluorine
17. Which of the following enzymes in glycolytic

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pathway is inhibited by fluoride
(a) glyceraldehyde-3-phosphate dehydrogenase (b)
phosphoglycerate kinase (c) pyruvate kinase (d) enolase
18. The regulatory key enzyme of cholesterol synthesis
is

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(a) HMG CoA synthase (b) HMG CoA reductase (c)
HMG CoA lyase (d) mevalonate kinase
19. Reference range of serum calcium is
(a) 3-4 mg/dL (b) 9-11 mg/dL (c) 4-5 mg/dL (d) 96-106

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mg/dL

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20. Which of the following hormone acts a
physiological uncoupler
(a) cortisol (b) insulin (c) glucagon (d) thyroxine
Q2. Short Answer Questions 10 x 5 = 50
a. Enumerate any 5 phospholipids with their

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biochemical role
b. Mechanisms of enzymes inhibition
C. Describe calcium metabolism
d. Regulation of blood glucose
e. Explain the fluid mosaic model of cell membrane

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f. Explain the phase I of xenobiotic metabolism
g. Mucosal block theory of iron absorption
h. Describe fatty liver and add note on lipotropic factors
i. Electron transport chain
j. A two-month-old child was brought to pediatrician

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with complaints of vomiting after each feed. Mother
gave history of
failure to gain weight and frequent diarrhea for the last
1 month. On physical examination, child had jaundice
and

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cataract. Benedict's test was positive and glucose
oxidase test was negative (1+1+3)
i. What is the most probable inborn error of metabolism
ii. Name the enzyme deficient
iii. Explain the biochemical basis of jaundice and

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cataract
Q3. Long Answer Questions 3 x 10 = 30

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a. A sixty-year-old male was admitted in Medicine ICU
with complaints of severe chest pain and profuse
sweating. His ECG

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showed the changes of acute myocardial infarction.
Mention different biochemical tests for confirming the
above
diagnosis along with its reference range. Describe the
different diagnostic and prognostic enzymatic markers

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with their
change in concentration with time in the above case.
(4+6)
b. Describe biosynthesis of urea. How it is regulated,
add a note on disorders related to it. (5+2+3)

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C. 1. A 15-year-old high school boy had difficulty in
performing his work in dim light. Dietary history
revealed he does not like
following foods -carrots, papaya and fish liver oil.
Based on history and chief complaint the probable

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diagnosis would be? Name the biochemical compound
which
is responsible for the above condition. (2)
II. Discuss its metabolism under following headings
(1+4+3)

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i. Requirement
ii. Functions
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