Jabalpur
MBBS First Professional Examination Feb-2023
Subject- Biochemistry
Paper-I
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(NEW SCHEME)Time: 3:00 Hours
Maximum Marks :100
Instructions:
a) All questions are compulsory
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b) Draw diagrams wherever necessaryc) Answers of Questions and Sub-questions must be
written strictly according to serial order of question paper.
d) MCQ has to be answered in theory answer book
e) Please write MCQ answer neatly and in serial order
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with black or blue pen in brackets; for example: - 1. (a) 2.(c)
f) MCQ has to be answered only once, any kind of
repetition or cutting or erasing or whitener will be
considered as malpractice, such answers will not be
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counted in marks and action will be taken according toUFM rules of university.
g) Subjective answer should be answered in up to 30
words per marks. For example, if a question having 2
marks should answered in up to 60 marks.
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Total MCQs: 10 x 1 = 101. Lysosomes are produced by the
(a) Nucleus
(b) Mitochondria
(c) Golgi apparatus
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(d) Ribosomes2. Transmembrane proteins serve as
(a) lon channels
(b) Carriers
(c) Receptors
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(d) All of the above3. Lactose intolerance is due to deficiency of enzyme
(a) Lactase
(b) Amylase
(c) Sucrase
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(d) All of the above4. Which of the following is an epimeric pair
(a) Glucose and Galactose
(b) Galactose and Mannose
(c) Fructose and Galactose
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(d) Lactose and Maltose5. Pellagra is due to deficiency of
(a) Thiamine
(b) Niacin
(c) Riboflavin
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(d) Vit. B126. RDA of copper for adults is
(a) 5-1 mg
(b) 2-3 mg
(c) 3.5-4.5 mg
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(d) 9-11 mg7. Normal LDL cholesterol level is
(a) <100 mg/dl
(b) >150 mg/dl
(c) 20-30 mg/dl
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(d) 200-220 mg/dl8. Which of the following has protective effect against
malaria
(a) Hb Bart
(b) HbF
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(c) HbM(d) HbS
9. Glycine is used for synthesis of
(a) Thyroxine
(b) Niacin
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(c) Serotonin(d) Heme
10. Bence-Jones proteins are excreted in the urine of
patients of
(a) Diabetes Mellitus
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(b) Nephrotic Syndrome(c) Multiple Myeloma
(d) All of the above
Long Answer Questions 2 x 20 = 40
Q2.a. Give on account on how fatty acids are activated
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and transported into the mitochondria. Describe the
reactions of Beta-oxidation in the mitochondrial matrix.
Add a note on ATP yield from palmitate:
b. Case study: -A 57-year-old male was brought to the
emergency with a history of 12 hrs of shortness of breath,
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coughing and tightness in the chest region. The symptomsappeared suddenly. His past medical history is significant
for diabetes mellitus and hypertension. He is a known
smoker and alcoholic. At the time of admission his BP
was 180/100mm of Hg. The laboratory tests showed
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CKMB as 45 IU/L (Ref Range 5-25 IU/L).1. Suggest the probable diagnosis
2. define enzymes end its classification.
3. define isoenzyme also discuss different isoenzyme
forms of any two relevant enzyme along with their
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characteristics and clinical significance4. management
Brief Answer Questions 6 x 05 = 30
Q3.a. Structure of cell-membrane
b. Discuss the synthesis of glucose from non-carbohydrate
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sourcesc. Classify) protein based on tl1cir functions, with
suitable example
d. Causes and deficiency manifestations of calcium.
e. Communication skill and Its 1mpor1once in doctor
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patient relationship.f. Detoxification by conjugation.
Short Answer Questions 10 x 2 = 20
Q4.a. Risk factors for Atherosclerosis
b. What is oxidative phosphorylation
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c. Biochemical role of oxytocin and ADH.d. Deficiency of vitamin C.
e. Why Cataract is seen in diabetic patient.
f. Respiratory acidosis
g. Why low levels of Vit31Tlln O 12 is seen in
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vegetariansh. Biologically important peptides
i. Disorders of urea cycle
j. Energetics of glycolysis
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