Jabalpur
MBBS First Professional Examination April-2022
Subject- Biochemistry
Paper-II
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(NEW SCHEME)Time: 3:00 Hours
Maximum Marks :100
Instructions:
a) All questions are compulsory
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b) Draw diagrams wherever necessaryc) Answers of Questions and Sub-questions must be
written strictly according to serial order of question paper.
d) MCQ has to be answered in theory answer book
e) Please write MCQ answer neatly and in serial order
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with black or blue pen in brackets; for example: - 1. (a) 2.(c)
f) MCQ has to be answered only once, any kind of
repetition or cutting or erasing or whitener will be
considered as malpractice, such answers will not be
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counted in marks and action will be taken according toUFM rules of university.
Q1. Total MCQs: 20
20 x 1 = 20
1. Rate limiting enzyme in heme synthesis is
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(a) heme synthase(b) ALA dehydratase
(c) ALA synthase
(d) uroporphyrinogen synthase
2. Normal range of albumin is
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(a) 3.5-5.5 gm/dL(b) 6-8 gm/dL
(c) 3.5-5.5 mmol/dL
(d) 6-8 mmol/dL
3. Conjugated hyperbilirubinemia with increased alkaline
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phosphatase level is present in(a) viral hepatitis
(b) obstructive jaundice
(c) hemolytic jaundice
(d) physiological jaundice
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4. The first protein to be excreted in urine in glomerulardamage is
(a) albumin
(b) transferrin
(c) hemoglobin
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(d) Bence jones protein5. Major intracellular cation is
(a) sodium
(b) potassium
(c) magnesium
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(d) calcium6. Basal metabolic rate is increased by all the following
EXCEPT
(a) fever
(b) thyroxine
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(c) starvation(d) cold climate
7. The normal range of plasma bicarbonate is
(a) 5-7 mEq/L
(b) 10-15 mEq/L
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(c) 21-26 mEq/L(d) 30-37 mEq/L
8. Which of the following hormones affects fluid and
electrolyte balance
(a) epinephrine
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(b) glucagon(c) thyroxine
(d) aldosterone
9. RNA in a mixture can be identified by
(a) southern blotting
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(b) northern blotting(c) western blotting
(d) none
10. Specific dynamic action for protein is
(a) 5%
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(b) 13%(c) 30%
(d) 60%
11. Tumour suppressor gene are sometimes called
(a) antioncogenes
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(b) proto-oncogenes
(c) oncogene
(d) proximate carcinogen
12. Serum urea and creatine are markers of
(a) liver function
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(b) renal function(c) pancreatic function
(d) gastric function
13. Immunoglobulins are classified on basis of
(a) light chains
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(b) heavy chains(c) carbohydrate content
(d) electrophoretic ability
14. In a 70 kg adult, the total body water content is
(a) 42L
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(b) 28L(c) 14L
(d) 3.5L
15. Which of the following separates DNA like a zip
opener
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(a) DNA ligase(b) DNA polymerase
(c) DNA helicase
(d) DNA topoisomerase
16. Human genome map where genes are visualized as
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bands with the help of a chemical dye is(a) cytogenic map
(b) gene linkage map
(c) restriction fragment length
(d) physical map
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17. All of the following are terminating codons EXCEPT(a) UAA
(b) UGG
(c) UAG
(d) UGA
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18. All of the following are anti-oxidant enzymesEXCEPT
(a) superoxide dismutase
(b) catalase
(c) glutathione peroxidase
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(d) cytochrome p450 mono-oxygenase19. A boy was stung by an unknown insect. He
experienced respiratory distress within minutes and lapsed
into unconsciousness. This may be mediated by
(a) IgG
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(b) IgE(c) sensitized T cells
(d) complement
20. DNA synthesis or extension is the third step of PCR,
which is carried out at
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(a) 95?C(b) 55?C
(c) 72?C
(d) room temperature
Q2. Short Answer Questions
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10 x 5 = 50a. 50-year-old male came in medicine OPD with chief
complaint of swelling in joint of great toe. On biochemical
laboratory investigations, physician noticed the increased
serum uric acid. Physician diagnosed him to be suffering
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with gout. Explain the metabolic pathways steps alongwith enzymes that is affected in above patient with its
biochemical correlation.
b. Explain acid base disorders with their compensatory
mechanism
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c. Applications of recombinant DNA technologyd. A 60-year-old male is admitted in medicine ICU with
complaints of increased micturition and abdominal pain.
He was known case of chronic kidney disease (CKD).
Describe different tests which can be performed in above
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patient for the measurement of glomerular filtration rate(GFR).
e. Define replication. Write a note on DNA repair
mechanism
f. Free radicals and antioxidants
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g. Write the features of primary and secondarydehydration
h. Quality control in clinical laboratory
i. Describe the disorders of heme synthesis
j. Balanced diet and specific dynamic action
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Q3. Long Answer Questions
3 x 10 = 30
a. A 45-year-old man had acute pain in the right
abdomen. He was diagnosed with gall stones
i. What are the various types of jaundice? Which type of
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jaundice do gall stones causeii. What investigations can be done in the blood and
urine to find out the severity and type of jaundice
iii. What is the relationship of cholesterol in bile to
development of gall stones? Why do bile acids help to
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prevent development of gall stonesb. A 5-year-old child with chief complaints of acute onset
of pain both lower limbs and past history of painful
episodes of abdomen, upper limb presented to casualty.
He is pale and febrile. On examination spleen is palpable
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and icterus is present. History reveals he is known case ofsickle cell disease.
i. What is the etiopathogenesis of sickle cell disease
ii. Explain polymerization of HbS in deoxygenated state
iii. Explain electrophoresis findings in sickle cell
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diseaseiv. Enlist the complications of sickle cell disease
c. Describe the process of protein synthesis in
prokaryotes. How does it differ from protein synthesis in
eukaryotes
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***Document Outline
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