Jabalpur
MBBS First Professional Examination Feb-2021
Subject- Biochemistry
Paper-II
--- Content provided by FirstRanker.com ---
(NEW SCHEME)Time: 3:00 Hours
Maximum Marks :100
Instructions:
a) All questions are compulsory
--- Content provided by FirstRanker.com ---
b) Draw diagrams wherever necessaryc) Answers of Questions and Sub-questions must be
written strictly according to serial order of question paper.
d) MCQ has to be answered in theory answer book
e) Please write MCQ answer neatly and in serial order
--- Content provided by FirstRanker.com ---
with black or blue pen in brackets; for example: - 1. (a) 2.(c)
f) MCQ has to be answered only once, any kind of
repetition or cutting or erasing or whitener will be
considered as malpractice, such answers will not be
--- Content provided by FirstRanker.com ---
counted in marks and action will be taken according toUFM rules of university.
Q1. Total MCQs: 20
1. Termination of the synthesis of RNA molecule is
signaled by a sequence in the template strand of the DNA
--- Content provided by FirstRanker.com ---
molecule, a signal that is recognized by a terminationprotein 20 x 1 = 20
(a) Rho factor
(b) sigma factor
(c) delta factor
--- Content provided by FirstRanker.com ---
(d) epsilon factor2. The correct statement concerning RNA and DNA
polymerases is
(a) RNA polymerases use nucleoside diphosphatase
(b) RNA polymerase requires primers and adds bases at
--- Content provided by FirstRanker.com ---
5' end of the growing polynucleotide(c) DNA polymerases can add nucleotides at both ends
of the chain
(d) all RNA and DNA polymerases can add nucleotides
only at 3' end of the growing polynucleotide chain
--- Content provided by FirstRanker.com ---
3. The enzyme DNA ligase(a) introduces super helical twists
(b) connects the end of two DNA chains
(c) unwinds the double helix
(d) synthesizes RNA primers
--- Content provided by FirstRanker.com ---
4. Restriction endonucleases(a) cut RNA chains at specific locations
(b) excise introns from hnRNA
(c) remove Okazaki fragments
(d) acts as defensive enzymes to protect the host
--- Content provided by FirstRanker.com ---
bacterial DNA from foreign organisms5. All of the following statements about uric acid is true
EXCEPT
(a) it can be formed from allantoin
(b) formation of uric acid stones in kidneys can be
--- Content provided by FirstRanker.com ---
decreased by alkalinization(c) uric acid begins to dissociate at pH above 5.8
(d) it is present in plasma mainly as monosodium urate
6. The daily total body water derived from oxidation of
foodstuffs is about
--- Content provided by FirstRanker.com ---
(a) 100 ml(b) 300 ml
(c) 600 ml
(d) 1000 ml
7. Minimum excretory urinary volume for waste product
--- Content provided by FirstRanker.com ---
elimination in 24hrs is(a) 200-300 ml
(b) 200-400 ml
(c) 500-600 ml
(d) 800 ml
--- Content provided by FirstRanker.com ---
8. All of the following features are found in bloodchemistry in uncompensated lactic acidosis EXCEPT
(a) pH is decreased
(b) bicarbonate is decreased
(c) pCO2 is normal
--- Content provided by FirstRanker.com ---
(d) anion gap is normal9. During compensation of respiratory alkalosis, all of the
following changes occur EXCEPT
(a) decreased secretion of hydrogen ions by renal
tubules
--- Content provided by FirstRanker.com ---
(b) increased excretion of sodium in urine
(c) increased excretion of bicarbonate in urine
(d) increased excretion of ammonia in urine
10. Normal quantity of urobilinogen excreted in the feces
per day is about
--- Content provided by FirstRanker.com ---
(a) 10-25 mg(b) 50-250 mg
(c) 300-500 mg
(d) 700-800 mg
11. The normal range of indirect bilirubin in serum is
--- Content provided by FirstRanker.com ---
(a) 0-0.1 mg/100ml(b) 0.1-0.2 mg/100ml
(c) 0.2-0.7 mg/100ml
(d) 0.8-1.0 mg/100ml
12. The normal values for creatinine clearance varies
--- Content provided by FirstRanker.com ---
from(a) 20-40 ml/min
(b) 40-60 ml/min
(c) 70-85 ml/min
(d) 95-105 ml/min
--- Content provided by FirstRanker.com ---
13. Methemoglobin can be reduced to hemoglobin by(a) removal of hydrogen
(b) vitamin C
(c) glutathione
(d) creatinine
--- Content provided by FirstRanker.com ---
14. Alpha fetoprotein level in serum is increased in(a) prostatic cancer
(b) hepatoma
(c) cancer in lungs
(d) nephritis
--- Content provided by FirstRanker.com ---
15. Which of the following enzymes produce a freeradical in macrophages
(a) SOD
(b) catalase
(c) GSH peroxidase
--- Content provided by FirstRanker.com ---
(d) NOS16. The minimum daily requirement of proteins in food
for a normal healthy adult is
(a) 0.2 gm/kg body weight
(b) 0.5 gm/kg body weight
--- Content provided by FirstRanker.com ---
(c) 0.7 gm/kg body weight(d) 1.5 gm/kg body weight
17. Which has no role in calculating calorie requirements
(a) respiratory quotient
(b) specific dynamic action
--- Content provided by FirstRanker.com ---
(c) basal metabolic rate(d) physical activity
18. Ratio of carbohydrates, fats and proteins in balanced
diet should be
(a) 50:40:10
--- Content provided by FirstRanker.com ---
(b) 60:20:20(c) 50:10:40
(d) 70:20:10
19. A 2-year-old boy presents to OPD with poor eating for
past few weeks. Recently he has developed a wound on
--- Content provided by FirstRanker.com ---
his leg which shows poor healing. On examination heappears plump but apathetic. He has dry, sparse golden
hair and skin appears thick and pigmented. Abdomen is
distended. His serum albumin is 1.5 g/dL. What is the
diagnosis
--- Content provided by FirstRanker.com ---
(a) anorexia nervosa(b) starvation
(c) marasmus
(d) kwashiorkor
20. The laboratory reports the following ABG: pH 7.33,
--- Content provided by FirstRanker.com ---
pCO2 40 mmHg (N 35-45) and HCO3 20 mEq/L (N 22-26), you interpret these results as
(a) respiratory acidosis
(b) metabolic acidosis
(c) respiratory alkalosis
--- Content provided by FirstRanker.com ---
(d) metabolic alkalosisQ2. Short Answer Questions
Write short notes on any THREE of the following:
a. Dehydration
b. Nitrogen balance
--- Content provided by FirstRanker.com ---
c. Tumour markersd. Applications of polymerase chain reaction
e. Gout
f. Eukaryotic post transcriptional RNA processing
g. Types of RNA
--- Content provided by FirstRanker.com ---
h. Water intoxication
i. Give an example of some oncogenic viruses. Name
some anti-carcinogens
j. Explain the concept of balanced diet
Q3. Long Answer Questions
--- Content provided by FirstRanker.com ---
a. A 67-year-old female presented at clinic with intensejaundice. She had noted that her stools had been very pale.
Laboratory test revealed a very high level of direct
bilirubin. The level of alkaline phosphatase was markedly
elevated (1+2+2+2+3)
--- Content provided by FirstRanker.com ---
i. What is the probable diagnosisii. Why color of stools Is very pale
iii. What will be the status of bilirubin and urobilinogen
in urine
iv. Why is alkaline phosphatase markedly elevated
--- Content provided by FirstRanker.com ---
v. What do you understand by direct and indirectbilirubin
b. A person presents himself with untreated diabetes
mellitus, he is then treated for acidosis (1+2+2+2+3)
i. What is the type of acidosis
--- Content provided by FirstRanker.com ---
ii. What is the normal bicarbonate/carbonic acid ratioiii. What will happen to the ratio in this patient
iv. How will compensation occur
v. What is the role of kidney in regulation of acid base
balance in the body
--- Content provided by FirstRanker.com ---
c. Classify renal function tests. Describe serum and urinemarkers of renal functions (4+3+3)
***