Download MPMSU MBBS 1st Year Biochemistry Paper II Nov 2023 Question Paper

Madhya Pradesh Medical Science University,
Jabalpur
MBBS First Professional Examination Nov-2023
Subject- Biochemistry
Paper- II

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(NEW SCHEME)
Time: 3:00 Hours
Maximum Marks :100
) All questions are compulsory
b) Draw diagrams wherever necessary

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c) Answers of Questions and Sub-questions must be
written strictly according to serial order of question paper.
d) MCQ has to be answered in theory answer book
e) Please write MCQ answer neatly and in serial order
with black or blue pen in brackets; for example: - 1. (a) 2.

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(c)
f) MCQ has to be answered only once, any kind of
repetition or cutting or erasing or whitener will be
considered as malpractice, such answers will not be
counted in marks and action will be taken according to

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UFM rules of university.
g) Subjective answer should be answered in up to 30
words per marks. For example, if a question having 2
marks should answered in up to 60 marks.
Q1. Total MCQs: 10

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1. An amino acid required for porphyrin synthesis is

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(a) proline
(b) glycine
(c) serine
(d) histidine

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2. A cosmid is a
(a) large bacterial plasmid
(b) viral plasmid
(c) hybrid of plasmid and phage
(d) yeast plasmid

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3. The most abundant immunoglobin present in plasma is
(a) IgA
(b) IgG
(c) IgM
(d) IgD

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4. Normal anion gap in plasma is around
(a) 1-5 mEq/L
(b) 8-12 mEq/L
(c) 20-25 mEq/L
(d) 35-40 mEq/L

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5. Unit of clearance is
(a) mg/dL
(b) mmol/day
(c) mg/min
(d) mL/min

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6. Which of the following chemotherapeutic drugs works
by inhibiting de novo purine synthesis
(a) acyclovir

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(b) methotrexate
(c) azidodeoxythymidine

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(d) 5-fluorouracil
7. Unconjugated bilirubin is raised mostly in
(a) hemolytic jaundice
(b) obstructive jaundice
(c) carcinoma of pancreas

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(d) stone in gall bladder
8. Most important physiological buffer in the blood is
(a) hemoglobin buffer system
(b) acetate buffer
(c) phosphate buffer

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(d) bicarbonate buffer
9. The main biological targets for attack by free radical
are all EXCEPT
(a) PUFA
(b) protein

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(c) DNA
(d) glycosaminoglycans
10. Cigarette smoke inhibits the activity of
(a) alpha 1-antitrypsin
(b) ceruloplasmin

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(c) alpha 2-macroglobulin
(d) c- reactive protein
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Q2. Long Answer Questions 2 x 20 = 40

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a. A 4 years old boy suffered from pain in joints,

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hypotonia, developmental delay, irritability, showed signs
of mental retardation and evidences of self-mutilation. On
examination there was testicular atrophy and hematuria.
The serum uric acid level was 10 mg/dL
i. What is the probable diagnosis

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ii. Which enzyme is defective in this disease
iii. What is the normal level of serum uric acid in
humans
iv. What is the mode of inheritance of this disease
V. What is the biochemical basis of this condition

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b. Classify liver function tests according to various
functions of liver. Write enzymatic, non-enzymatic and
urinary markers based on type of jaundice
Q3. Brief Answer Questions 6 x 05 = 30
a. Explain metabolic acidosis and its compensation

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b. Describe post translational modifications and
inhibitors of this process
c. Explain kidney function tests
d. Explain recombinant DNA technology and its
applications

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e. Explain eukaryotic rRNA processing
f. Explain the mechanism of free radical formation and
describe different antioxidants with their mechanisms
Q4. Short Answer Questions 10 x 2 = 20
a. Enumerate tumour markers

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b. Enumerate cause of overhydration
c. Types of RNA and their functions
d. Enumerate derivatives of hemoglobin
e. Write types of gout and their biochemical causes
f. Uses of quality control in biochemistry lab

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g. Enumerate disorders due to changes in
immunoglobulins
h. Enumerate oncogenes
i. Write various types of plasma proteins
j. Write any two types of mutations with examples

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83
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