Jabalpur
MBBS Second Professional Examination August-
2024
Subject- Pharmacology
--- Content provided by FirstRanker.com ---
Paper-I (new scheme)Time: 3:00 Hours
Maximum Marks :100
Instructions:
a) All questions are compulsory
--- Content provided by FirstRanker.com ---
b) Draw diagrams wherever necessaryc) Answers of Questions and Sub-questions must be
written strictly according to serial order of question
paper.
d) MCQ has to be answered in theory answer book
--- Content provided by FirstRanker.com ---
e) Please write MCQ answer neatly and in serial orderwith black or blue pen in brackets; for example: - 1.
(a) 2. (c)
f) MCQ has to be answered only once, any kind of
repetition or cutting or erasing or whitener will be
--- Content provided by FirstRanker.com ---
considered as malpractice, such answers will not becounted in marks and action will be taken according to
UFM rules of university.
g) Subjective answer should be answered in up to 30
words per marks. For example, if a question having 2
--- Content provided by FirstRanker.com ---
marks should answered in up to 60 marks.Q1. Total MCQs: 10
10 x 1 = 10
1. Which of the following is a prodrug?
(a) Ampicillin
--- Content provided by FirstRanker.com ---
(b) Captopril(c) Levodopa
(d) Phenytoin
2. Which of the following is an enzyme inhibitor?
(a) Ketoconazole
--- Content provided by FirstRanker.com ---
(b) Rifampicin(c) Tolbutamide
(d) Phenobarbitone
3. Partial agonist possess:
(a) Maximum intrinsic
--- Content provided by FirstRanker.com ---
activity and low affinity(b) High intrinsic activity
and no affinity
(c) Low intrinsic activity
and high affinity
--- Content provided by FirstRanker.com ---
(d) Low intrinsic activityand low affinity
4. This anti-platelet drug is a prodrug and blocks P2Y12
receptor.
(a) Aspirin
--- Content provided by FirstRanker.com ---
(b) Tirofiban(c) Clopidogrel
(d) Abciximab
5. Approved drug for obesity is:
(a) Topiramate
--- Content provided by FirstRanker.com ---
(b) Orlistat(c) Metformin
(d) Sibutramine
6. Which of the following anti-histaminic has very less
cholinergic side effects?
--- Content provided by FirstRanker.com ---
(a) Promethazine(b) Chlorpheniramine
(c) Triprolidine
(d) Loratadine
7. Anticholinergic used pre-anesthetically to reduce
--- Content provided by FirstRanker.com ---
secretions is:(a) Glycopyrrolate
(b) Homatropine
(c) Ipratropium
(d) Dicyclomine
--- Content provided by FirstRanker.com ---
8. Mechanism of action of Zileuton is:(a) Inhibit production of
IgE
(b) Inhibit lipoxygenase
(c) Inhibit cyclooxygenase
--- Content provided by FirstRanker.com ---
(d) Inhibit activity of mastcells
9. Antihypertensive which can be used in patients with
gout and diabetes mellitus is:
(a) Thiazide
--- Content provided by FirstRanker.com ---
(b) Enalapril
(c) Propranolol
(d) Diazoxide
10. Side effect of corneal microdeposits is seen most
commonly with which of the following drugs?
--- Content provided by FirstRanker.com ---
(a) Esmolol(b) Amiodarone
(c) Adenosine
(d) Bretylium
Q2. Long Answer Questions
--- Content provided by FirstRanker.com ---
2 x 20 = 40a. A 42-year-old man complains of recurrent epigastric
pain, anorexia, and nausea. Clinical history revealed that
pain episodes started 2 years earlier and became frequent
for the last two months. The patient had taken antacid as
--- Content provided by FirstRanker.com ---
medication to relieve pain. He smokes a pack of cigarettesand 10 cups of coffee daily. Barium meal examination was
suggestive of gastric ulcers, which was confirmed by
endoscopy. On serological examination, the patient has H.
pylori infection.
--- Content provided by FirstRanker.com ---
I. What will be the treatment of this patient?II. Write drugs used for peptic ulcer?
III. Describe the mechanism of action of proton pump
inhibitor?
IV. Write therapeutic uses and adverse effects of Proton
--- Content provided by FirstRanker.com ---
pump inhibitors?b. A 45-year-old male presents to the emergency room
with substernal chest pain radiating towards the left
shoulder.
I. What should be its immediate and prophylactic
--- Content provided by FirstRanker.com ---
management?II. Write the difference between classical and
vasospastic angina?
III. Write the mechanism of action of nitrate and their
role in angina pectoris?
--- Content provided by FirstRanker.com ---
IV. What are the adverse drug effects and therapeuticuses of Nitrates?
Q3. Brief Answer Questions
6 x 05 = 30
a. Write pharmacotherapy of open-angle glaucoma?
--- Content provided by FirstRanker.com ---
b. Write therapeutic uses and adverse effects ofAngiotensin-converting enzyme inhibitors?
C. Discuss in short potassium-sparing diuretics?
d. Classify beta-blockers? Write the role of beta-blockers
in Hypertension?
--- Content provided by FirstRanker.com ---
e. Enumerate atropine substitutes. Write therapeutic usesand ADRs of atropine substitutes used in the eye.
f. Write the difference between competitive and non-
competitive receptor antagonism?
Q4. Short Answer Questions
--- Content provided by FirstRanker.com ---
10 x 2 = 20a. Write the rationale for using beta-2 agonists in
bronchial asthma?
b. Define Pharmacovigilance. Which is the national
Reporting Centre in India?
--- Content provided by FirstRanker.com ---
c. Classify antiemetic drugs?d. Explain why edrophonium is the preferred drug for
differentiation between cholinergic and myasthenic crisis?
e. Write the treatment of severe migraine?
f. Write antihypertensive drugs which are safe in
--- Content provided by FirstRanker.com ---
pregnancy?g. Write the treatment of acute iron poisoning?
h. Write complications of thiazide diuretics?
i. Explain why adrenaline is added to local anesthetics?
j. Explain why heparin is preferred as an anticoagulant in
--- Content provided by FirstRanker.com ---
pregnancy than warfarin sodium?***