Jabalpur
MBBS Second Professional Examination Feb-
2023
Subject- Pharmacology
--- Content provided by FirstRanker.com ---
Paper-I (new scheme)Time: 3:00 Hours
Max. Marks: 75
a) All questions are compulsory
b) Draw diagrams wherever necessary
--- Content provided by FirstRanker.com ---
c) Answers of Questions and Sub-questions must bewritten strictly according to serial order of question
paper.
d) MCQ has to be answered in theory answer book
e) Please write MCQ answer neatly and in serial order
--- Content provided by FirstRanker.com ---
with black or blue pen in brackets; for example: - 1.(a) 2. (c)
f) MCQ has to be answered only once, any kind of
repetition or cutting or erasing or whitener will be
considered as malpractice, such answers will not be
--- Content provided by FirstRanker.com ---
counted in marks and action will be taken according toUFM rules of university.
g) Subjective answer should be answered in up to 30
words per marks. For example, if a question having 2
marks should answered in up to 60 marks.
--- Content provided by FirstRanker.com ---
Q1. Total MCQs: 10 ? 10 x 1 = 101) All of the following reactions are catalyzed by
microsomal enzymes EXCEPT-
(a) Glucuronidation
(b) Acetylation
--- Content provided by FirstRanker.com ---
(c) Oxidation(d) Glutathione conjugation
2) A patient Raj Kishore was given pilocarpine. All of the
following can be the features seen in him EXCEPT-
(a) Sweating
--- Content provided by FirstRanker.com ---
(b) Salivation(c) Miosis
(d) Cycloplegia
3) Antagonism between acetylcholine and atropine
(a) Competitive antagonism
--- Content provided by FirstRanker.com ---
(b) Physiological antagonism(c) Non Competitive antagonism
(d) Irreversible antagonism
4) Which drug should not be given in pregnancy?
(a) Labetalol
--- Content provided by FirstRanker.com ---
(b) ACE inhibitors(c) Hydralazine
(d) Methyl dopa
5) Which of the following is NOT an adverse effect of
heparin
--- Content provided by FirstRanker.com ---
(a) Bleeding(b) Thrombocytopenia
(c) Hypokalemia
(d) Osteoporosis
6) In the middle of a clinical trial, one participant decides
--- Content provided by FirstRanker.com ---
to withdraw from the trial. But, the investigatorpressurizes the participant to continue in the study till it
completes. Which of the following ethical principles does
the investigator violate
(a) Justice
--- Content provided by FirstRanker.com ---
(b) Autonomy(c) Beneficence
(d) Non-Maleficence
7) The treatment of orthostatic angina is
(a) Nitroglycerine & Atenolol
--- Content provided by FirstRanker.com ---
(b) Nitroglycerine & Diltiazem(c) Amlodipine & Atenolol
(d) Fludrocortisone & High sodium diet
8) Drug of choice for Congenital long QTc syndrome is
(a) MgSo4
--- Content provided by FirstRanker.com ---
(b) Digitalis(c) Propranolol
(d) Ibutilide
9) Which of the following act by inhibiting cGMP
degradation
--- Content provided by FirstRanker.com ---
(a) Nitrates(b) ANP
(c) Sildenafil
(d) BNP
10) Drug of choice for cancer chemotherapy induced early
--- Content provided by FirstRanker.com ---
vomiting is
(a) Domperidon
(b) Aprepitant
(c) Ondansetron
(d) Hyoscine
--- Content provided by FirstRanker.com ---
Q2. Long Answer Questions ? 2 x 20 = 40a. Classify beta blockers and discuss therapeutic uses and
adverse effects of propranolol.
b. Classify drugs used in bronchial asthma and discuss
therapeutic uses and adverse effects of salbutamol.
--- Content provided by FirstRanker.com ---
Q3. Brief Answer Questions ? 6 x 05 = 30a. First order kinetics.
b. Pharmacotherapy of open angle glaucoma.
c. Iron preparations and iron therapy
d. Enumerate loop diuretics, their mechanism of action,
--- Content provided by FirstRanker.com ---
indications and adverse effect.e. Compare and contrast between Competitive and non
competitive antagonism.
f. Classify antiplatelet agents with examples. Write their
indications and adverse effects
--- Content provided by FirstRanker.com ---
Q4. Short Answer Questions ? 10 x 2 = 20a. Enumerate four uses of carbonic anhydrase inhibitors
b. Enumerate four drugs for prophylaxis of migraine
c. Enumerate four mucolytic expectorants
d. Enumerate Four uses of Proton pump inhibiting drugs
--- Content provided by FirstRanker.com ---
e. Topical nasal decongestantsf. Enumerate advantages of low molecular weight heparin
g. Pharmacological management of organophosphorus
poisoning
h. Define pharmacogenetics with suitable examples.
--- Content provided by FirstRanker.com ---
i. Explain the pharmacological basis of usingpyridostigmine in myasthenia gravis.
j. Explain the pharmacological basis of using adrenaline
in the management of anaphylactic shock.
***
--- Content provided by FirstRanker.com ---