MBBS DEGREE - IInd PROFESSIONAL - SUPPLEMENTARY EXAMINATION - APRIL 2025
PATHOLOGY - PAPER - I
SECTION A - Multiple Choice Questions (MCQs)
PAPER CODE : 2521130004
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SET : BNote: Choose one correct answer in the OMR sheet provided. No overwriting should be done.
Time: 20 Minutes
(20 x 1 = 20 MARKS)
1. Liquefactive necrosis is seen in:
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a) Brainb) Lung
c) Spleen
d) Liver
2. The hallmark genetic abnormality in Chronic Myelogenous Leukemia (CML) is:
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a) Deletion of chromosome 13b) Point mutation in the p53 gene
c) Philadelphia chromosome
d) Trisomy 21
3. Nutmeg liver is a condition characterized by:
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a) Acute hepatitisb) Cirrhosis
c) Hepatic venous congestion
d) AL amyloid
4. The most common type of amyloid protein is:
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a) ATTR amyloidb) A amyloid
c) AA amyloid
d) AL amyloid
5. The most commonly used stain for routine histological examination is:
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a) Masson's trichromeb) Gram stain
c) Periodic acid-Schiff
d) Hematoxylin and eosin
6. Anti apoptotic gene?
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a) BCL-XLb) Bim
c) Bax
d) ?
7. In an X-linked recessive inheritance pattern, who is most likely to be affected by the disease?
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a) Males onlyb) Females only
c) Neither males nor females
d) Both males and females
8. Hemophilia B is a bleeding disorder caused by a deficiency in:
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a) Plateletsb) Vitamin K
c) Factor IX
d) Factor VIII
9. Which of the following is an example of an autoimmune disease?
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a) Rheumatoid arthritisb) Malaria
c) Tuberculosis
d) HIV/AIDS
10. Acute lymphocytic leukemia (ALL) is most commonly diagnosed in which age group?
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a) Young adultsb) Older adults
c) Adolescents
d) Children
11. Which cells are most directly involved in rejecting a transplanted organ?
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a) White blood cellsb) Plasma cells
c) Platelets
d) Red blood cells
12. The standard storage temperature for packed red blood cells is:
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a) 22?Cb) ?C
c) 4?C
d) -20?C
13. Retinoblastoma is primarily caused by:
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a) Environmental factorsb) Hormonal imbalance
c) Genetic mutation
d) Viral infection
14. Immune granulomas not seen in:
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a) Syphilisb) Brucellosis
c) Tuberculosis
d) Silicosis
15. Type I hypersensitivity is mediated by:
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a) IgE antibodiesb) T cells
c) IgM antibodies
d) IgG antibodies
16. Which of the following genes are most commonly associated with hereditary breast cancer?
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a) HER2b) BRCA1 and HER2
c) TP53 and PTEN
d) BRCA1 and BRCA2
17. Which of the following is risk factor for impaired bone fracture healing?
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a) Osteoporosisb) Diabetes mellitus
c) Malnutrition
d) All of the above
18. Fibroid necrosis is often associated with:
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a) Viral infectionsb) Bacterial infections
c) Ischemic injury
d) Immune complex-mediated diseases
19. The most common causes of Megaloblastic anemia are deficiencies in:
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a) Vitamin K and calciumb) Vitamin A and zinc
c) Vitamin B12 and folate
d) Iron and vitamin C
20. Down syndrome is caused by:
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a) An extra copy of chromosome 21b) A gene mutation
c) A viral infection
d) A bacterial infection
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