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First Year M.B.B.S. Examination April - 2023
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Physiology: Paper -I
Time: 3 Hours ] [ Total Marks: 100
? : / Instructions
(?) ? ? ? ? ? ? ? ?.
Fill up strictly the details of signs on your answer book
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| Name of the Examination: | First Year M.B.B.S. | Seat No.: |
| Name of the Subject : | Physiology: Paper -I | Student's Signature |
| Subject Code No.: | 2006000101020001 |
(2) SECTION A (MCQ) is given in separate sheet.
(3) Draw diagrams and flow chart wherever required.
Section A (MCQs) 20 Marks
1. Which of the following acts as cell adhesion molecule
a) Connexin b) Kinesin
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c) Actin d) Cadherin
Select the most appropriate choice in each of the following MCQ
2. All of the following transport process follow 'saturation kinetics' except
a) Simple diffusion b) Facilitated diffusion
c) Na+-Ca+ exchanger d) Na+ coupled active transport
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3. Enzymes catalases are present in
a) Lysosomes b) Peroxisomes
c) Ribosomes d) Mitochondria
4. The Equilibrium potential for Na+ is
a) +60mV b) +90mV
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c) +70mV d) +100mV
5. In the body muscle contractions are subtetanic type but not jerky because of
a) Recruitment of motor units
b) Frequency of nerve impulse
c) Asynchronous discharge of motor units
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d) Synchronization of nerve impulse
6. Eosinophilia occurs in
a) Stressful condition. b) Urticaria
c) Pyogenic infection. d) Corticosteroid therapy.
7. The function of suppressor T (Ts) cells is
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a) Secreting interleukin-2
b) Suppressing the activity of B lymphocytes.
c) Preventing the activity of cytotoxic T cells
d) Induction of Apoptosis
8. A 2-year-old boy bruises easily and has a history of nosebleeds. He has also had bleeding into his knee joints after minimal trauma. You would suspect that this patient has a deficiency of which coagulation factor?
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a) Prothrombin activator b) Factor II
c) Factor VIII d) Factor X
9. The property of aggregation of platelets is because of
a) von Willebrand factor b) Thrombosthenin
c) Thromboxane A2 d) Serotonin
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10. Atrioventricular dissociation occurs in
a) First degree AV nodal block b) Second degree AV nodal block
c) Third degree AV nodal block d) Mobitz type II block
11. Which is the most potent coronary vasodilator
a) Adenosine b) Lactate
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c) Prostaglandins d) Dopamine
12. Heart rate is calculated by dividing 1500 by distance between which of the following two consecutive waves?
a) P-P b) R-R
c) P-R d) T-T
13. Carbon monoxide poisoning is a type of
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a) Anemic hypoxia b) Histotoxic hypoxia
c) Hypoxic hypoxia d) Stagnant hypoxia
14. Given Tidal Volume = 540 ml, Anatomical Dead Space = 180 ml and Respiratory Rate = 14/min, calculate Alveolar Ventilation per minute
a) 4200 ml b) 6890 ml
c) 4680 ml d) 5040 ml
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15. Enzymes within the lung are responsible for the activation of
a) Angiotensin II b) Bradykinin
c) Prostaglandins d) Serotonin
16. Voluntary micturition
a) Depends on the integrity of a lumbar spinal reflex arc
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b) Is not possible after sensory denervation of the bladder
c) Involves stimulation of the detrusor muscle in the bladder by autonomic sympathetic nerves
d) Is normally accompanied by some reflux of bladder contents into the ureters
17. Aldosterone secretion tends to raise the volume of
a) Interstitial fluid b) Intracellular fluid
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c) Urine d) CSF
18. A patient with chronic renal failure has all of the following except
a) Increased Blood urea b) Increased Blood uric acid
c) Increased creatinine clearance d) Increased acid-base disturbance
19. Paralytic Salivary secretion is seen on sectioning of
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a) Tympanic nerve b) Auriculotemporal nerve
c) Chorda Tympani nerve d) Otic ganglion
20. The following stimulate pancreatic secretion rich in water and bicarbonate
a) Secretin b) Cholecystokinin
c) Gastrin d) Vagal stimulation
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Section - "B" (40 Marks)
Q.1 A 43-year-old man presents to the physician's clinic with complaints of epigastric pain. After a thorough workup, the patient is diagnosed with peptic ulcer disease. He is started on a medication that inhibits the "proton pump" of the stomach. (10 marks)
a. What is the "proton pump" that is referred to above? (1 mark)
b. What type of cell membrane transport would this medication be blocking? (1 mark)
c. Describe the types of transport where molecules use ATP as energy to move against concentration gradient across a cell membrane? (4 marks)
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d. Describe Peptic ulcer disease. (4 marks)
Q.2 Answer in Short (Any 5 out of 6) (5x3=15 marks)
1. Apoptosis
2. Draw a labelled diagram of Sarcomere
3. Functions of Monocytes
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4. Conducting system of heart
5. Excitation contraction coupling in smooth muscle
6. Importance of blood group matching in blood transfusion
Q.3 Short notes (Any 3 out of 4) (3x5=15 marks)
1. Ventricular events in Cardiac cycle (2+3marks)
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2. Immunoglobulins
3. Sites and Stages of erythropoiesis
4. Functions of Liver
Section - "C" (40 Marks)
Q.4 Define Cardiac output. Explain any one method by which Cardiac Output is determined. Explain the factors that regulate Cardiac output. (1+3+6=10marks)
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Q.5 Answer in Short (Any 5 out of 6) (10 marks)
1. Acclimatization at high altitude
2. Definition and classification of Diuretics
3. Pancreatic Enzymes
4. Morphological classification of Anaemia
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5. Role of ADH in homeostasis
6. Respiratory membrane
Q.6 Short notes (Any 3 out of 4) (5x3=15 marks)
1. Neural Regulation of Respiration. (1+4 marks)
2. Lung Surfactant and it's function and applied aspect (2.5 +2.5marks)
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3. What is Tubular maximum for glucose (TmG) and what is Splay? Explain with diagram.
4. Functions of Juxtaglomerular apparatus
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