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2106000102020101-S
EXAMINATION MARCH-APRIL 2024
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BACHELOR OF MEDICINE AND BACHELOR OF SURGERY (SECOND YEAR)
PHARMACOLOGY (PAPER - I ) - LEVEL 2 OMR
[Time: As Per Schedule] [Max. Marks:100]
| Instructions: 1. Fill up strictly the following details on your answer book. --- Content provided by FirstRanker.com --- a. Name of the Examination : BACHELOR OF MEDICINE AND BACHELOR OF SURGERY (SECOND YEAR)b. Name of the Subject: PHARMACOLOGY (PAPER – I)-LEVEL 2 OMR c. Subject Code No : 2106000102020101-S 2. Sketch neat and labelled diagram wherever necessary. 3. Figures to the right indicate full marks of the question. --- Content provided by FirstRanker.com --- 4. Answers should be precise and to the point.5. Give examples and figures if needed. 6. First 20 mins have been allotted to solve multiple choice Questions. | Seat No: --- Content provided by FirstRanker.com --- Student's Signature |
Section I
Q.1 Multiple choice questions (MCQs) 1*20=20
Instructions:
- Encircle the most appropriate answer.
- Each question carries one mark and there is no negative marking.
- Overwriting is not allowed.
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- Acidic drugs bind to :
a. Albumin b. ß Globulin
c. Enzyme d. Receptor - A highly ionized drug:
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a. Is excreted mainly by the kidney
b. Can cross the placental barrier easily
c. Is well absorbed from the intestine
d. Accumulates in the cellular lipids - At toxic doses, zero order kinetics is seen in:
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a. Penicillin b. Phenytoin
c. Valproate d. Carbamazepine - Which of the following has cytoplasmic receptor:
a. Epinephrine b. Insulin
c. FSH d. Cortisol - Therapeutic monitoring of plasma level of drug is done when using all of the following drugs except:
a. Warfarin b. Gentamycin
c. Phenytoin d. Cyclosporine - In which phase of clinical trials, post-marketing surveillance of a drug is carried out:
a. Phase I b. Phase II--- Content provided by FirstRanker.com ---
c. Phase III d. Phase IV - Synaptic transmitter in the autonomic ganglion is:
a. Adrenaline b. Dopamine
c. Acetylcholine d. Noradrenaline - All are cholinergic agents EXCEPT:
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a. Galantamine b. Donepezil
c. Tacrine d. Memantine - Methylphenidate is drug of choice for:
a. Obsessive compulsive disorder
b. ADHD (attention deficit hyperkinetic disorder)--- Content provided by FirstRanker.com ---
c. Enuresis
d. Autism - All of the following are therapeutic uses of prazosin, except:
a. Peripheral vascular disease
b. Phaeochromocytoma--- Content provided by FirstRanker.com ---
c. Lupus Erythematosus
d. Scorpion sting - Ethosuximide can be used for the treatment of:
a. Generalized tonic clonic seizures
b. Absence seizures--- Content provided by FirstRanker.com ---
c. Complex seizures
d. Myoclonic seizures - Neural tube defect is an adverse effect of:
a. Valproate b. Phenytoin
c. Diazoxide d. None - Anti-Parkinsonism drug that is a selective COMT inhibitor:
a. Entacapone b. Ropinirole
c. Pergolide d. Pramipexole - Drug useful in malignant hyperthermia is:
a. Halothane b. Succinyl choline--- Content provided by FirstRanker.com ---
c. Dantrolene d. Haloperidol - Which of the following drug is not an opioid agonist?
a. Heroin b. Ketamine
c. Methadone d. Codeine - Which of the following increases uric acid excretion?
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a. Allopurinol b. Aspirin
c. Colchicine d. Probenecid - Most common cause of Mobius syndrome is use of which of the following drug in pregnancy?
a. Misoprostol b. Thalidomide
c. Methotrexate d. Dinoprostone - Gastric lavage is contraindicated in :
a. Salicylate poisoning
b. Kerosene poisoning
c. Morphine poisoning
d. Organophosphate poisoning - For preanesthetic medication all of the drugs can be used except:
a. Diazepam b. Glycopyrrolate
c. Metoclopramide d. Phenobarbitone - Antihistaminic used for motion sickness is:
a. Cetirizine b. Meclizine--- Content provided by FirstRanker.com ---
c. Promethazine d. Fexofenadine
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Q.2 Answer in short [any five]: [3*5=15]
- Write a note on rational use of medicines.
- What is microsomal enzyme induction? Describe possible consequences of microsomal enzyme induction with examples.
- Explain potency and efficacy with the help of a suitable diagram.
- Mention the uses of anticholinergic drugs.
- Discuss the side effects and contraindications to propranolol.
- Give pharmacological basis for use of adrenaline in anaphylactic shock.
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Q.3 Write answers in details [any three]: [5*3=15]
- Describe mechanism of action and adverse effects of any 3 drugs from different groups used in treatment of glaucoma.
- Describe the process of synthesis, storage, release and uptake of catecholamine.
- Classify anti-cholinesterases. Describe the pharmacotherapy of organophosphorus poisoning.
- Define Adverse drug reaction and pharmacovigilance. Describe teratogenicity in detail.
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Q.4 Case based questions: [10*1=10]
A 35-year-old man complains of breathlessness for 1 month which is increasing in frequency with 3-4 attacks per week. Breathlessness is seen while doing his day-to-day activities. Patient is provisionally diagnosed as moderate persistent bronchial asthma. He is prescribed Metered dose inhaler of formoterol and budesonide.
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- What is the advantage of combining formoterol and budesonide in this patient? 2
- Mention the advantages of giving the above drugs in metered dose inhaler as compared to oral route. 2
- Which side effects can occur in this patient due to the prescribed drugs? 2
- If this patient brought to emergency department as 'status asthamaticus' what treatment should be given? 4
Section II
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Q.5 Answer in short [any five]: [3*5=15]
- Write a note on bioavailability of a drug.
- Classify drugs used in cough. Describe dextromethorphan in short.
- Describe the treatment of methyl alcohol poisoning.
- Enumerate second generation antihistaminics. Mention their uses.
- Write a note on prophylaxis of migraine.
- Enlist selective serotonin reuptake inhibitors and their therapeutic uses.
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Q.6 Write answers in details [any three]: [5*3=15]
- Classify Nonsteroidal anti-inflammatory drugs (NSAIDs). Describe uses and adverse effects of aspirin.
- Compare and contrast benzodiazepines and barbiturates.
- Enumerate commonly used drugs for generalized tonic clonic seizure. Describe briefly the mechanism of action and adverse effects of any two of them.
- Classify antirheumatoid drugs. Describe mechanism of action and adverse effects of any three DMARDS (Disease modifying antirheumatic drugs).
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Q.7 Case based questions: 10*1=10
A 30 years old man had a gradual onset of delusions and auditory hallucinations. He was diagnosed as schizophrenia by a psychiatrist and started him on tab. Haloperidol 2mg twice daily. A few weeks later although he improved clinically, he developed stiffness and rigidity of upper and lower limbs. He was diagnosed as drug induce parkinsonism.
- Explain the basis of drug induced parkinsonism. Which drug should be Started in this patient for treatment of drug induced parkinsonism? Why? 1+1+2
- Describe the adverse effects of the drug used for this patient. 4
- Enumerate antipsychotic drugs which have less chances of drug induced Parkinsonism and can be used in this patient. 2
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