RGUHS M.Pharm 1st Year Last 10 Years 2011-2021 Question Papers || Rajiv Gandhi University of Health Sciences
First Semester Degree Examination
[Time: 3 Hours] [Max. Marks: 75]
Pharmacological and Toxicological Screening Methods-I
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Q.P. CODE: 5135
Your answers should be specific to the questions asked.
Draw neat, labeled diagrams wherever necessary.
LONG ESSAY (Answer any Three) 3 X 10 = 30 Marks
- Enumerate various preclinical models to evaluate anti-anxiety activity of drugs. Explain any two screening models.
- Enumerate screening methods for antipsychotic drugs and explain pole climbing avoidance test in rats.
- Write a note on chemical mediators of inflammation. Explain one in vitro and one in-vivo method to screen an anti-inflammatory agent.
- What are the methods to screen antidiabetic agents? Discuss the euglycaemic clamp technique and method to evaluate alpha glucosidase inhibitory activity.
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SHORT ESSAY (Answer any Nine) 9 X 5 = 45 Marks
- What are the pharmacological applications of transgenic animals?
- Write a note on preclinical screening methods for drugs used in Alzheimer's disease.
- Explain one model each from in vivo and in vitro models to evaluate antidiarrheal activity of a drug.
- Explain one model each from in vivo and in vitro models to evaluate anti-asthmatic activity of a drug.
- Explain the stress induced ulcer model and pylorus ligation method to evaluate an anti-ulcer agent.
- Enumerate various preclinical models to evaluate antihypertensive activity of a drug. Explain any one model.
- Enumerate the models for screening of antianginal activity and explain the lagendorff technique for isolated mammalian heart.
- What is the role of lipoprotein in atherosclerosis? Explain the high-fat diet model for screening of antiatherosclerotic agents.
- Write a note on alternatives to animal experiments in pharmacology.
- Explain the general principles of immunoassays.
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