RGUHS M.Pharm 1st Year Last 10 Years 2011-2021 Question Papers || Rajiv Gandhi University of Health Sciences
Rajiv Gandhi University of Health Sciences
First Year M. Pharm Degree Examination
Time: Three Hours Max. Marks: 100 Marks
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Bio-Pharmaceutics and Pharmacokinetics
(Revised Scheme 4)
Q.P. CODE: 9338
Your answers should be specific to the questions asked.
Draw neat, labeled diagrams wherever necessary. Answer any ten questions.
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LONG ESSAY (Answer any TEN) 10 X 10 = 100 Marks
- Enumerate the different methods of determining absorption. Discuss in detail in-vitro methods.
- Discuss in detail physico-chemical factors affecting the absorption of drugs.
- Explain volume of distribution. How volume of distribution is estimated? Give its significance.
- Define the terms relative and absolute bioavailability. Explain different methods used to determine AUC.
- Explain the pharmacokinetics of a drug given by extravascular route which follows one compartment open model.
- How do you determine elimination rate constant using urinary excretion data?
- Explain the process of renal excretion of drugs.
- Discuss the causes of non-linearity in pharmacokinetics and write briefly the tests to determine the same.
- Define drug dissolution and explain various theories of drug dissolution.
- What are the main factors that influence drug dosing in renal disease? Explain briefly the different methods for adjusting drug dose in renal disease.
- Write a note on therapeutic drug monitoring.
- Explain about Biopharmaceutics classification system.
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