Download RGUHS (Rajiv Gandhi University of Health Sciences) M.Pharma 2019 June (Master of Pharmacy) 1st Year (First Year) 1st Year Medicinal Chemistry II Revised Scheme Previous Question Paper

Rajiv Gandhi University of Health Sciences
First Year M. Pharm Degree Examination - JUNE-2019
[Time: 3 Hours]
[Max. Marks: 100]
MEDICINAL CHEMISTRY - II
(Revised Scheme)
Q.P. CODE : 7923
Your answers should be specific to the questions asked.
Draw neat labeled diagrams wherever necessary. Answer FOUR questions
LONG ESSAYS (ANSWER ANY FOUR)
4 X 25 = 100 Marks
1.
a) Explain the mechanism of action and chemical modifications in the development of extended
spectrum of cephalosporins.
b) Explain the chemistry and mechanism of action of carbapanems.
2.
a) Explain the chemistry and therapeutic values of enzyme inhibitors of carbohydrate
metabolism.
b) Give an account on chemistry, distribution and therapeutic values of enkephalins.
3.
Give detail account on discovery of drug prototypes and their derivatives by perceived effect of
chemicals, observations during routine laboratory studies and unanticipated consequences of
therapy with appropriate examples for each.
4.
a) Explain phodophyllotoxin as a lead molecule in the development of clinically useful
anticancer agents.
b) Explain in detail the development of new and better analgesics using morphine as a lead
molecule.
5.
a) Outline the rationale and practical consideration in design of prodrugs.
b) Explain in detail the types and nature of chemical bonds involved in prodrug design.
6.
Give detail account on chemistry, mechanism of action and therapeutic uses of inhibitors of
DNA polymerase, DNA topoisomerases and DNA methyl transferees.
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