RGUHS M.Pharm 2nd Year Last 10 Years 2011-2021 Question Papers || Rajiv Gandhi University of Health Sciences
Second Semester M. Pharm Examination
[Time: 3 Hours] [Max. Marks: 75]
Advanced Biopharmaceutics and Pharmacokinetics -II
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Q.P. CODE: 5141
Your answers should be specific to the questions asked.
Draw neat, labeled diagrams wherever necessary.
LONG ESSAY (Answer any Three) 3 X 10 = 30 Marks
- Explain mechanisms of drug absorption.
- Define bioavailability. Explain the methods of enhancing bioavailability of drugs.
- Discuss pharmacokinetics of drugs which follow one compartment when given as IV bolus injection.
- Explain the applications of pharmacokinetics in designing of targeted drug delivery system.
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SHORT ESSAY (Answer any Nine) 9 X 5 = 45 Marks
- Explain physico-chemical factors influencing dissolution of drug product.
- Explain Michaelis-Menten equation.
- Write short notes on nonlinear kinetics.
- Explain any one method of determination of AUC.
- How to estimate V max and Km at steady state in non-linear pharmacokinetics.
- Write a note on two compartment model.
- Explain rate limiting steps in drug absorption.
- Write a note on in vitro-in vivo correlation.
- Explain Noyes-Whitney’s equation.
- Write a note on drug interaction linked to transporters.
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