Rajiv Gandhi University of Health Sciences
Second Semester M. Pharmacy Examination
[Time: 3 Hours] [Max. Marks: 75]
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Computer Aided Drug Design -II
Q.P. CODE: 5159
Your answers should be specific to the questions asked.
Draw neat, labeled diagrams wherever necessary.
LONG ESSAY (Answer any Three) 3 X 10 = 30 Marks
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- Discuss the techniques used in virtual screening.
- Explain Hammett equation and electronic parameters and how they are determined?
- Explain fragment based drug design.
- Write about receptor ligand interaction and how is it analysed?
SHORT ESSAY (Answer any Nine) 9 X 5 = 45 Marks
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- Describe the docking of agents on HMG-CoA reductase.
- Explain in detail In silico drug design.
- How the contour map is generated and analysed?
- Write a note on effect of substituents on log P.
- Discuss rigid docking.
- Explain how the pharmacophore features can be identified?
- Discuss how the ADMET properties of an experimental molecule can be predicted?
- Describe drug-receptor interaction.
- Explain the role of molecular modeling in drug design.
- Explain the statistical methods used in QSAR analysis.
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