RGUHS M.Pharm 2nd Year Last 10 Years 2011-2021 Question Papers || Rajiv Gandhi University of Health Sciences
Second Semester Degree Examination
[Time: 3 Hours] [Max. Marks: 75]
Advanced Biopharmaceutics and Pharmacokinetics
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Q.P. CODE: 5170
Your answers should be specific to the questions asked.
Draw neat, labeled diagrams wherever necessary.
LONG ESSAY (Answer any Three) 3 X 10 = 30 Marks
- Explain the Pharmacokinetics of a drug given by IV bolus, which follows one compartment open model.
- What is bioequivalence? Discuss in detail various bioequivalence study designs.
- Explain various Pharmaceutical factors affecting the drug absorption.
- Discuss in detail in-vitro, in-vivo correlation. Explain briefly dissolution profile comparisons.
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SHORT ESSAY (Answer any Nine) 9 X 5 = 45 Marks
- Write a note on cytochrome P-450 based drug interactions.
- Write a note on applications of Pharmacokinetics in targeted drug delivery systems.
- Discuss various factors to be considered in design of a drug product.
- Discuss the pH partition theory of drug absorption.
- Describe various in-situ methods of studying drug absorption.
- Write Michaelis-Menten equation. Write how do you estimate Vmax and Km?
- Define bioavailability. Write a note on various methods of assessing bioavailability.
- Discuss the various official methods of drug dissolution.
- Write a note on Pharmacokinetics and Pharmacodynamics of proteins and peptides.
- Discuss Noyes-Whitney equation of drug dissolution process.
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