Rajiv Gandhi University of Health Sciences
Second Semester M. Pharmacy Degree Examination
[Time: 3 Hours] [Max. Marks: 75]
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Principles of Drug Discovery -II
Q.P. CODE: 5179
Your answers should be specific to the questions asked.
Draw neat, labeled diagrams wherever necessary.
LONG ESSAY (Answer any Three) 3 X 10 = 30 Marks
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- Explain the factors to be considered in prodrug design with examples.
- Discuss about level of protein structure and their applications.
- What are the types of molecular docking? Explain any two docking based screening method.
- Explain Hansch analysis in detail with example.
SHORT ESSAY (Answer any Nine) 9 X 5 = 45 Marks
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- Explain about genomics in target identification and validation.
- Discuss about threading and homology protein structure modeling methods.
- Explain about the role of high throughput screening in rational drug design.
- What are the applications of NMR and X-ray crystallography in protein structure prediction?
- Explain about role of transgenic animals in target validation.
- Write a note on statistical methods used in QSAR analysis.
- What are the importance of proteomics in identification and validation of target?
- Discuss the basic principles involved in the design of prodrug.
- Explain about COMFA and COMSIA (Comparative Molecular Similarity Index Analysis).
- Explain about manual docking.
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