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Download RGUHS M.Pharm 2019 June 2nd Year 5183 Clinical Pharmacokinetics And Therapeutic Drug Monitoring Question Paper

Download RGUHS (Rajiv Gandhi University of Health Sciences) M.Pharma 2019 June (Master of Pharmacy) 1st Year (First Year) 2nd Year 5183 Clinical Pharmacokinetics And Therapeutic Drug Monitoring Previous Question Paper

This post was last modified on 11 June 2021

This download link is referred from the post: RGUHS M.Pharm 2nd Year Last 10 Years 2011-2021 Question Papers || Rajiv Gandhi University of Health Sciences


Rajiv Gandhi University of Health Sciences

Second Semester B.Pharmacy Degree Examination -

[Time: 3 Hours] [Max. Marks: 75]

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Clinical Pharmacokinetics and Therapeutic Drug Monitoring

Q.P. CODE: 5183

Your answers should be specific to the questions asked.

Draw neat, labeled diagrams wherever necessary.

LONG ESSAY (Answer any Three) 3 X 10 = 30 Marks

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  1. Define pharmacokinetic drug interactions. Explain the impact of drug interaction on induction and inhibition of drug metabolism with examples.
  2. Explain compartment and non-compartment modeling.
  3. Discuss the need and methods of dosage adjustments in pediatric population.
  4. What is analysis of population pharmacokinetic data? Explain the different methods.

SHORT ESSAY (Answer any Nine) 9 X 5 = 45 Marks

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  1. Define TDM and explain the indications for TDM of drugs.
  2. Write short notes on PK-PD correlation in Drug therapy.
  3. How do you calculate loading and maintenance dose in multiple dosing regimen.
  4. Explain the methods of determining bioavailability.
  5. Define and explain inter-individual and intra-individual variability.
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  7. Explain genetic polymorphism of CYP450 enzymes and its effects on drug metabolism.
  8. Dosage adjustment is necessary in pregnancy and lactation. Why?
  9. How do age and disease conditions influence drug dosage regimen.
  10. Explain the effect of renal disease on pharmacokinetics of drugs.
  11. Discuss the methods of determining creatinine clearance.
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This download link is referred from the post: RGUHS M.Pharm 2nd Year Last 10 Years 2011-2021 Question Papers || Rajiv Gandhi University of Health Sciences

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