Rajiv Gandhi University of Health Sciences
Second Semester B.Pharmacy Degree Examination -
[Time: 3 Hours] [Max. Marks: 75]
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Clinical Pharmacokinetics and Therapeutic Drug Monitoring
Q.P. CODE: 5183
Your answers should be specific to the questions asked.
Draw neat, labeled diagrams wherever necessary.
LONG ESSAY (Answer any Three) 3 X 10 = 30 Marks
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- Define pharmacokinetic drug interactions. Explain the impact of drug interaction on induction and inhibition of drug metabolism with examples.
- Explain compartment and non-compartment modeling.
- Discuss the need and methods of dosage adjustments in pediatric population.
- What is analysis of population pharmacokinetic data? Explain the different methods.
SHORT ESSAY (Answer any Nine) 9 X 5 = 45 Marks
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- Define TDM and explain the indications for TDM of drugs.
- Write short notes on PK-PD correlation in Drug therapy.
- How do you calculate loading and maintenance dose in multiple dosing regimen.
- Explain the methods of determining bioavailability.
- Define and explain inter-individual and intra-individual variability.
- Explain genetic polymorphism of CYP450 enzymes and its effects on drug metabolism.
- Dosage adjustment is necessary in pregnancy and lactation. Why?
- How do age and disease conditions influence drug dosage regimen.
- Explain the effect of renal disease on pharmacokinetics of drugs.
- Discuss the methods of determining creatinine clearance.
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