Download RGUHS (Rajiv Gandhi University of Health Sciences) M.Pharma 2019 January (Master of Pharmacy) 1st Year (First Year) 1st Year 5119 Advanced Medicinal Chemistry Previous Question Paper

Rajiv Gandhi University of Health Sciences
First Semester M. Pharm Degree Examination - JAN-2019
Time: Three Hours
Max. Marks: 75 Marks
Advanced Medicinal Chemistry
Q.P. CODE: 5119
Your answers should be specific to the questions asked.
Draw neat, labeled diagrams wherever necessary.
LONG ESSAY (Answer any Three)
3 X 10 = 30 Marks
1.
Discuss the modification of various functional groups in the design of prodrugs.
2.
Explain the various stages of drug discovery. Add a note on validation of drug targets.
3.
Write a note on rational design of non-covalently and covalently binding enzyme inhibitors.
4.
Explain and classify antineoplastic agents with example. Write the synthesis and mechanism of
action of Methotrexate.
SHORT ESSAY (Answer any Nine)
9 X 5 = 45 Marks
5.
Write a note on COX-2 inhibitors. Write the synthesis of any one COX-2 inhibitor.
6.
Outline the genetic principles of drug resistance
7.
Explain various theories of drug-receptor interaction with example.
8.
Explain various strategies followed to combat drug resistance in anticancer therapy.
9.
Write a note on Bioisosteric replacement and position isomer in analog design.
10.
Write the importance and application of high throughput screening.
11.
Write a note on combinatorial chemistry.
12.
Classify H1 and H2 receptor antagonist with example. Explain the synthesis of any one H2
antagonist.
13.
Write a brief note on designing of peptidomimetics.
14.
Write a note on artificial enzyme.
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