Rajiv Gandhi University of Health Sciences
First Semester M. Pharmacy Examination
Time: Three Hours Max. Marks: 75 Marks
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Biopharmaceutics and Pharmacokinetics
Q.P. CODE: 5125
Your answers should be specific to the questions asked.
Draw neat, labeled diagrams wherever necessary.
LONG ESSAY (Answer any Three) 3 X 10 = 30 Marks
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- Discuss in detail physic-chemical factors affecting the absorption of drugs.
- Discuss the one compartmental model after the administration of IV bolus. How do you determine the Pharmacokinetic parameters?
- Write on Wagner-Nelson method to determine absorption rate constant.
- Describe in-vitro drug dissolution testing models. Explain their merits and limitations.
SHORT ESSAY (Answer any Nine) 9 X 5 = 45 Marks
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- Define the terms relative and absolute bioavailability. Explain the determination of BA by urinary excretion method.
- Define drug dissolution and explain various theories of drug dissolution.
- Define Pharmacokinetics. Classify pharmacokinetic models. Write advantages of Pharmacokinetic model.
- Define bioequivalence. Discuss the various considerations in bioequivalence studies.
- Compare and contrast between active and passive transport of drugs.
- Explain the application of Pharmacokinetics in drug development and designing of dosage forms.
- Explain Michaelis — Menten equation in determining non-linearity.
- Discuss in detail in-situ methods of determining absorption.
- Explain BCS classification of drugs. Add a note on biowaivers.
- Explain the influence of gastric emptying and intestinal transit time on absorption of drugs.
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