RGUHS M.Pharm 1st Year Last 10 Years 2011-2021 Question Papers || Rajiv Gandhi University of Health Sciences
First Semester M. Pharm Examination
[Time: 3 Hours] [Max. Marks: 75]
Pharmacological and Toxicological Screening Methods-I
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Q.P. CODE: 5135
Your answers should be specific to the questions asked.
Draw neat, labeled diagrams wherever necessary.
LONG ESSAY (Answer any Three) 3 X 10 = 30 Marks
- Enumerate methods to evaluate antidepressant activity of an agent. Discuss one in-vitro and one in-vivo method.
- What are the mechanisms by which antianxiety agents act? List the screening methods and discuss any two methods.
- List out the various screening methods for antiulcer activity. Discuss one stress induced and one chemically induced ulcer model.
- List the commonly used methods to screen an agent for antihypertensive agents. Discuss one in-vitro and one in-vivo method.
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SHORT ESSAY (Answer any Nine) 9 X 5 = 45 Marks
- Write a note on the pharmacological uses of rat as laboratory animal.
- Write a brief note on maintenance of laboratory animals.
- Explain two models for screening an agent for antiparkinsonian activity.
- Explain a model to evaluate central analgesic activity of an agent.
- Write a note on preclinical screening methods of antiemetic agents.
- Explain two preclinical models to evaluate antipyretic activity of an agent.
- Enumerate the models for screening of antianginal activity and explain the Langendorff technique.
- List the methods to screen antidiabetic agents, explain any one model.
- Write a note on limitations of animal experimentation.
- Write a note on immunoassays.
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