Rajiv Gandhi University of Health Sciences
First Semester M. Pharm Degree Examination
[Time: 3 Hours] [Max. Marks: 75]
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Cellular and Molecular Pharmacology
Q.P. CODE: 5136
Your answers should be specific to the questions asked.
Draw neat, labeled diagrams wherever necessary.
LONG ESSAY (Answer any Three) 3 X 10 = 30 Marks
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- What is cell cycle? Discuss the various phases of eukaryotic cell cycle. Explain the role of cell cycle regulators and inhibitors.
- Explain the applications of metabolomics and genomics in Pharmacogenomics.
- Explain the JAK/STAT and MAPK signalling pathway and write their significance.
- What are cell cultures? Classify with examples. Explain the media requirements and techniques of cell cultures.
SHORT ESSAY (Answer any Nine) 9 X 5 = 45 Marks
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- Discuss the DNA transfer using viral vectors and explain the clinical applications of gene therapy.
- Discuss the role of siRNA in gene silencing.
- Explain cell signalling through GPCR.
- Explain the unique role of nitric oxide (NO) as neurotransmitter.
- Describe the concepts of micro array techniques.
- Discuss the role of genomics in research.
- Describe the basic concepts and applications of biosimilars.
- What are drug transporters and discuss the impact of genetic variations in drug transporters.
- Explain the principles and applications of glucose uptake assay.
- Explain the principles and applications of flow cytometry.
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