Download RGUHS (Rajiv Gandhi University of Health Sciences) M.Pharma 2019 January (Master of Pharmacy) 1st Year (First Year) 1st Year 9338 Bio Pharmaceutics And Pharmacokinetics Revised Scheme 4 Previous Question Paper

Rajiv Gandhi University of Health Sciences
First Year M. Pharm Degree Examination - JAN-2019
Time: Three Hours
Max. Marks: 100 Marks
Bio-Pharmaceutics and Pharmacokinetics
(Revised Scheme 4)
Q.P. CODE: 9338
Your answers should be specific to the questions asked.
Draw neat, labeled diagrams wherever necessary. Answer any ten questions.
LONG ESSAY (Answer any TEN)
10 X 10 = 100 Marks
1.
Explain in detail various non per-oral routes of drug absorption.
2.
Write the objectives of bioavailability studies. Explain the methods for measurement of
bioavailability.
3.
Define drug distribution. Explain various physiological barriers for drug distribution.
4.
Define the equivalence terms. Write the equation for similarity and dissimilarity factor and
explain.
5.
Explain Michael's Menten equation. How do you estimate Km and Vmax?
6.
Explain the pharmacokinetics of a drug given by extravascular route which follows one
compartment open model.
7.
What is protein binding? Explain the kinetics and significance of protein binding.
8.
Classify pharmacokinetic models and explain briefly about each.
9.
Explain pH partition hypothesis and its limitations.
10.
What are the pharmacokinetic considerations in designing a dosage regimen?
11.
Write a note on Phase-II biotransformation reactions.
12.
Explain in detail about factors involved in Individualizing drug therapy.
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