Download RGUHS M.Pharm 2019 Jan 2nd Year 5150 Modern Bio Analytical Techniques Question Paper

Second Semester B.Pharm Degree Examination - FirstRanker.com

[Time: 3 Hours] [Max. Marks: 75]

Modern Bio-Analytical Techniques

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Q.P. CODE: 5150

Your answers should be specific to the questions asked.

Draw neat, labeled diagrams wherever necessary.

LONG ESSAY (Answer any Three) 3 X 10 = 30 Marks

1. Write a note on origin of GCP and give the guidelines of GCP as per ICMR.

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2. Explain the properties of biological media. Explain the analysis of peptides and protein drugs.
3. Define Bioavailability and Bioequivalence. Explain the CDSCO guidelines for design and conduct of BA/BE studies.
4. Explain the general principle and procedures involved in extraction of drugs from biological matrices by solid phase extraction method.

SHORT ESSAY (Answer any Nine) 9 X 5 = 45 Marks

5. Write a note on audit and requirements for GCP compliance.

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6. Explain the general principle and procedure involved in protein precipitation.
7. Write the principle and methodology involved in membrane filtration.
8. With suitable examples explain the separation of bio-molecules by gel electrophoresis.
9. Briefly explain the retention of samples and maintenance of records of BA/BE studies.
10. Explain the methodologies for the analysis of prodrugs.

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11. Write the principle and procedures involved in the bio-molecule separation by HPLC technique.
12. Explain the facilities to conduct BA/BE studies.
13. Briefly explain the methodology for the analysis of drug metabolites.
14. Give the principle and procedure involved in bio-molecule separation by LC MS/MS technique.

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