This download link is referred from the post: RGUHS M.Pharm 2nd Year Last 10 Years 2011-2021 Question Papers || Rajiv Gandhi University of Health Sciences
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Second Semester“m{“fi’fig?rtn fl"ekgré%OE‘xaminatlon
[Time: 3 Hours] [Max. Marks: 75]
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Computer Aided Drug Design
Q.P. CODE: 5159
Your answers should be specific to the questions asked.
Draw neat, labeled diagrams wherever necessary.
LONG ESSAY (Answer any Three) 3 X 10 = 30 Marks
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- Explain briefly different physiochemical properties used to determine the Quantitative structure activity relationship of drug molecules.
- Explain different energy minimization methods and compare global minimum conformation and bioactive conformation.
- Discuss the fragment based drug design and homology modeling.
- Explain the pharmacophore based and structure based In-silico virtual screening protocols.
SHORT ESSAY (Answer any Nine) 9 X 5 = 45 Marks
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- Explain in brief Hammett equation and sigma parameters.
- Enumerate the different methods in the calculation of partition co-efficient.
- Discuss the Free Wilson analysis and give its applications.
- What are the various statistical methods adopted for the QSAR analysis.
- Discuss the different approaches of 3D QSAR.
- Discuss the agents used in the inhibition of HMG Co-A reductase enzyme.
- Discuss the different types of drug receptor interactions.
- Explain how ADMET properties are predicted for new molecules.
- Write a note on receptor/enzyme interaction and its analysis.
- How do you identify features of pharmacophore?
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This download link is referred from the post: RGUHS M.Pharm 2nd Year Last 10 Years 2011-2021 Question Papers || Rajiv Gandhi University of Health Sciences
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