Second Semester M. Pharmacy Degree Examination
Time: Three Hours Max. Marks: 75 Marks
Advanced Biopharmaceutics and Pharmacokinetics
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Q.P. CODE: 5170
Your answers should be specific to the questions asked.
Draw neat, labeled diagrams wherever necessary.
LONG ESSAY (Answer any Three) 3 X 10 = 30 Marks
- Define absorption. Discuss in detail mechanisms of drug absorption.
- Discuss in detail one-compartment open model for a drug administered as IV infusion. Give the schematic representation, graphs and equations for the same.
- What are the objectives and considerations in bioavailability studies?
- Explain the different theories of dissolution process.
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SHORT ESSAY (Answer any Nine) 9 X 5 = 45 Marks
- Explain biological factors affecting drug absorption.
- Discuss in detail various bioequivalence study designs.
- Define the terms relative and absolute bioavailability. Explain any two methods used to determine AUC.
- Discuss Pharmacodynamic drug interactions.
- Write a detailed note on in vitro-in vivo correlation.
- Explain the various factors leading to non-linearity.
- What are different compendial methods of dissolution?
- Write the application of pharmacokinetic in the design and development of new dosage forms.
- Discuss the significance of Michaelis - Menten equation in estimation of Km and Vmax.
- Discuss absorption of drugs from non-per oral routes.
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This download link is referred from the post: RGUHS M.Pharm 2nd Year Last 10 Years 2011-2021 Question Papers || Rajiv Gandhi University of Health Sciences
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