Download RGUHS M.Pharm 2019 Jan 2nd Year 5179 Principles Of Drug Discovery II Question Paper

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Faculty of Health Sciences

Second Semester M. Pharmacy Examination

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[Time: 3 Hours] [Max. Marks: 75]

Principles of Drug Discovery -II

Q.P. CODE: 5179

Your answers should be specific to the questions asked.

Draw neat, labeled diagrams wherever necessary.

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LONG ESSAY (Answer any Three) 3 X 10 = 30 Marks

1. With the help of a flowchart explain an overview of modern drug discovery process.
2. Write a note on various In silico lead discovery techniques.
3. Explain various In silico techniques for drug likeness prediction.
4. Discuss the physicochemical parameters used to quantify structure in QSAR.

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SHORT ESSAY (Answer any Nine) 9 X 5 = 45 Marks

1. Explain the concept of prodrug in drug discovery.
2. Explain the role of proteomics and bioinformatics in drug discovery and validation.
3. Write a note on high throughput screening for lead identification in a drug discovery process.
4. Explain the use of NMR in prediction of protein structure.

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5. Write a note on ligand-based pharmacophore modeling for drug discovery.
6. Write a note on de novo drug design.
7. Explain the role of siRNA in target identification and validation.
8. Write a note on applications of prodrug to improve site-selective drug delivery.
9. Explain the major steps in molecular docking.

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10. Write a note on traditional drug design.

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