Faculty of Health Sciences
Second Semester M. Pharmacy Examination
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[Time: 3 Hours] [Max. Marks: 75]
Principles of Drug Discovery -II
Q.P. CODE: 5179
Your answers should be specific to the questions asked.
Draw neat, labeled diagrams wherever necessary.
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LONG ESSAY (Answer any Three) 3 X 10 = 30 Marks
- With the help of a flowchart explain an overview of modern drug discovery process.
- Write a note on various In silico lead discovery techniques.
- Explain various In silico techniques for drug likeness prediction.
- Discuss the physicochemical parameters used to quantify structure in QSAR.
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SHORT ESSAY (Answer any Nine) 9 X 5 = 45 Marks
- Explain the concept of prodrug in drug discovery.
- Explain the role of proteomics and bioinformatics in drug discovery and validation.
- Write a note on high throughput screening for lead identification in a drug discovery process.
- Explain the use of NMR in prediction of protein structure.
- Write a note on ligand-based pharmacophore modeling for drug discovery.
- Write a note on de novo drug design.
- Explain the role of siRNA in target identification and validation.
- Write a note on applications of prodrug to improve site-selective drug delivery.
- Explain the major steps in molecular docking.
- Write a note on traditional drug design.
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