Download RGUHS (Rajiv Gandhi University of Health Sciences) M.Pharma 2019 January (Master of Pharmacy) 1st Year (First Year) 2nd Year 5179 Principles Of Drug Discovery II Previous Question Paper

Rajiv Gandhi University of Health Sciences
Second Semester M. Pharm Degree Examination - JAN-2019
[Time: 3 Hours]
[Max. Marks: 75]
Principles of Drug Discovery -II
Q.P. CODE: 5179
Your answers should be specific to the questions asked.
Draw neat, labeled diagrams wherever necessary.
LONG ESSAY (Answer any Three)
3 X 10 = 30 Marks
1.
With the help of a flowchart explain an overview of modern drug discovery process.
2.
Write a note on various In silico lead discovery techniques.
3.
Explain various In silico techniques for drug likeness prediction.
4.
Discuss the physicochemical parameters used to quantify structure in QSAR.
SHORT ESSAY (Answer any Nine)
9 X 5 = 45 Marks
5.
Explain the concept of prodrug in drug discovery.
6.
Explain the role of proteomics and bioinformatics in drug discovery and validation.
7.
Write a note on high throughput screening for lead identification in a drug discovery
process.
8.
Explain the use of NMR in prediction of protein structure.
9.
Write a note on ligand-based pharmacophore modeling for drug discovery.
10.
Write a note on de novo drug design.
11.
Explain the role of siRNA in target identification and validation.
12.
Write a note on applications of prodrug to improve site-selective drug delivery.
13.
Explain the major steps in molecular docking.
14.
Write a note on traditional drug design.
* * * * *

---

Document Outline

• ??
• ??
• ??

---