Rajiv Gandhi University of Health Sciences
Second Semester M. Pharm Degree Examination
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[Time: 3 Hours] [Max. Marks: 75]
Modern Bio-Analytical Techniques -II
Q.P. CODE: 5150
Your answers should be specific to the questions asked.
Draw neat, labeled diagrams wherever necessary.
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LONG ESSAY (Answer any Three) 3 X 10 = 30 Marks
- Describe the determination of Fluticasone propionate in human plasma by HPLC.
- Explain the properties of plasma and serum.
- Explain the principle and procedure involved in the protein precipitation.
- Describe the bio analytical method.
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SHORT ESSAY (Answer any Nine) 9 X 5 = 45 Marks
- Explain the principle involved in electrophoresis.
- Explain the advantages and disadvantages of membrane filtration.
- Write the mechanism of separation of bio molecules by size exclusion principle in HPLC.
- Briefly explain about the formatting and texting of SOP.
- Write a note on record maintenance of bioavailability studies.
- Describe the columns used in HPLC for the separation of bio molecules.
- Write a note on ICH guidelines of GCP.
- What is reverse phase mechanism of solid phase extraction processes.
- Explain about retention of BA/BE samples.
- Explain how to audit GCP compliance.
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