Download RGUHS M.Pharm 2018 May 2nd Year 5159 Computer Aided Drug Design II Question Paper

Second Semester Pharm. Degree Examination

[Time: 3 Hours] [Max. Marks: 75]

Computer Aided Drug Design -II

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Q.P. CODE: 5159

Your answers should be specific to the questions asked.

Draw neat, labeled diagrams wherever necessary.

LONG ESSAY (Answer any Three) 3 X 10 = 30 Marks

1. Explain Hansch and Free Wilson method of analysis with a suitable example and relationship between them.

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2. Discuss the approaches for 3D-QSAR analysis.
3. Write the protocols to be followed in In silico virtual screening.
4. Discuss the energy minimization methods in molecular modeling.

SHORT ESSAY (Answer any Nine) 9 X 5 = 45 Marks

1. Describe the docking of agents on AchE.

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2. Explain the method of generation of 3D-structure of a protein.
3. What is log P? How it is determined? Give its significance.
4. Explain the docking of agents on DHFR enzyme.
5. Explain pharmacophore mapping.
6. Discuss homology modeling of a protein.

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7. Describe extra precision docking.
8. Explain the electronic parameters to be considered in QSAR.
9. Write a note on counter map analysis.
10. Discuss the role of computer aided drug design in drug discovery.

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