RGUHS M.Pharm 2nd Year Last 10 Years 2011-2021 Question Papers || Rajiv Gandhi University of Health Sciences
Second Semester M. Pharm Examination
[Time: 3 Hours] [Max. Marks: 75]
Pharmaceutical Process Chemistry - II
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Q.P. CODE: 5160
Your answers should be specific to the questions asked.
Draw neat, labeled diagrams wherever necessary.
LONG ESSAY (Answer any Three) 3 X 10 = 30 Marks
- Discuss the various stages of scale up process in detail.
- Define crystallization? How it is attempted from aqueous and non-aqueous solutions?
- Discuss catalytic hydrogenation by citing examples. Write a note on metal hydrides.
- Discuss the basic description of the occupational health and safety assessment series (OHSAS 1800).
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SHORT ESSAY (Answer any Nine) 9 X 5 = 45 Marks
- Write a note on genotoxic impurities in API.
- Define nucleation. Write a note on factors affecting nucleation.
- Write in detail about the various nitrating agents involved in nitration.
- Discuss the significance of validation of large scale process.
- Discuss the significance of steam distillation.
- Elaborate the kinetics of halogenations.
- Discuss the significance of H2O2 as nonmetallic oxidizing agents.
- Write a note on characteristics of cost-effective routes.
- Discuss fermentation process with respect to production of statins.
- Write a note on hazards labels of chemicals.
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