RGUHS M.Pharm 1st Year Last 10 Years 2011-2021 Question Papers || Rajiv Gandhi University of Health Sciences
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First Semester Degree Examination
[Time: 3 Hours] [Max. Marks: 75]
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Advanced Organic Chemistry - I
Q.P. CODE: 5118
Your answers should be specific to the questions asked.
Draw neat, labeled diagrams wherever necessary.
LONG ESSAY (Answer any Three) 3 X 10 = 30 Marks
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- Define and classify Carbanions. Write short note on structure, stability and reactions of carbanions.
- Explain the mechanism involved in Brook rearrangement and Sandmayer reaction.
- Explain any two methods for synthesis of Purine nucleus and give structure of any five drugs with purine nucleus.
- Explain retro-synthesis by involving functional group modifications with suitable examples.
SHORT ESSAY (Answer any Nine) 9 X 5 = 45 Marks
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- Explain mechanism of E1 reaction with suitable example.
- Make a comparative statement on reactions of aliphatic vs aromatic compounds.
- Explain asymmetric epoxidation with suitable example.
- Write short note on application of Beyer-Villiger oxidation in organic synthesis.
- Explain synthetic applications of n-bromo succinamide and diethyl azodicarboxylate.
- Write short note on amino protecting groups.
- Explain synthetic applications of titanium chloride and osmium tetroxide in organic synthesis.
- Explain the synthesis and uses of 6-mercaptopurine.
- Write the structure and uses for any five quinoline containing drugs.
- Write short note on application of retro-synthesis in prospect of drug discovery process.
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